Formulation of PPAR-gamma agonist as surface modified PLGA nanoparticles for non-invasive treatment of diabetic retinopathy: in vitro and in vivo evidences
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DOI: 10.1016/j.heliyon.2020.e04589
Abstract: Diabetic retinopathy is one of the worst complications of diabetes and it is treated by invasive method. We prepared a surface modified poly (D, L-lactide-co-glycolide) i.e. PLGA nanoparticles for delivery of pioglitazone-a peroxisome proliferator-activated receptor-gamma… read more here.
Keywords: plga nanoparticles; surface modified; gamma agonist; diabetic retinopathy ... See more keywords
PPAR Gamma Agonist Leriglitazone Recovers Alterations Due to Pank2-Deficiency in hiPS-Derived Astrocytes
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DOI: 10.3390/pharmaceutics15010202
Abstract: The novel brain-penetrant peroxisome proliferator-activated receptor gamma agonist leriglitazone, previously validated for other rare neurodegenerative diseases, is a small molecule that acts as a regulator of mitochondrial function and exerts neuroprotective, anti-oxidative and anti-inflammatory effects.… read more here.
Keywords: derived astrocytes; hips derived; gamma agonist; agonist leriglitazone ... See more keywords