Manipulation of Developmental Gamma-Globin Gene Expression: an Approach for Healing Hemoglobinopathies
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DOI: 10.1128/mcb.00253-20
Abstract: β-Hemoglobinopathies are the most common monogenic disorders, and a century of research has provided us with a better understanding of the attributes of these diseases. Allogenic stem cell transplantation was the only potentially curative option… read more here.
Keywords: fetal hemoglobin; hemoglobin; gamma globin; gene ... See more keywords
The relationship between the variations in Gγ and Aγ promotors and the Hereditary Persistence of Fetal Hemoglobin (HPFH).
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DOI: 10.14715/cmb/2018.64.1.7
Abstract: In the present study, sixty-two samples that have 1.5% and upper level of fetal hemoglobin (HbF), were examined to investigate the relationship between HbF level and non-deletional mutations in both Gγ (G gamma) globin (HBG2)… read more here.
Keywords: promotor; gamma globin; fetal hemoglobin; gene ... See more keywords
Genetic variants in the G gamma-globin promoter modulate fetal hemoglobin expression in the Colombian population
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DOI: 10.1590/1678-4685-gmb-2019-0076
Abstract: Abstract Fetal hemoglobin (HbF) is a determining factor for the development of sickle cell anemia. High HbF levels lower the intensity of symptoms of this disease. HbF levels can vary in patients with sickle cell… read more here.
Keywords: healthy individuals; hbf; gamma globin; promoter ... See more keywords