Gamma‐Glutamyl Cysteine Ligase Activity as a Proxy for Human T Cell Function and Drug‐Induced Immunosuppression
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DOI: 10.1002/advs.202501179
Abstract: T cell effector functions are critical for immune defense, but their dysregulation can cause diseases like immune exhaustion in cancer and loss of tolerance in autoimmunity. Curtailing these functions is essential in therapies such as… read more here.
Keywords: gamma glutamyl; cell; glutamyl cysteine; cell function ... See more keywords
The Association Between Serum Gamma‐Glutamyl Transferase and Gastrointestinal Cancer Risk: A Systematic Review and Meta‐Analysis
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DOI: 10.1002/cam4.70581
Abstract: Gamma‐glutamyl transferase (GGT) has been shown to have associations with several diseases including cancers. Previous studies have investigated the effect of GGT levels on the gastrointestinal (GI) cancer incidence. We aim to systematically investigate these… read more here.
Keywords: cancer; glutamyl transferase; gamma glutamyl; gastrointestinal cancer ... See more keywords
Gamma‐Glutamyl Transpeptidase‐to‐Platelet ratio predicts liver fibrosis in patients with concomitant chronic hepatitis B and nonalcoholic fatty liver disease
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24596
Abstract: The aim of this study was to compare the correlation of gamma‐glutamyl transpeptidase‐to‐platelet ratio (GPR), aspartate aminotransferase‐to‐platelet ratio index (APRI), fibrosis index‐4 (FIB‐4), and liver stiffness measurement (LSM) in the diagnosis of liver fibrosis, and… read more here.
Keywords: gamma glutamyl; glutamyl transpeptidase; fibrosis; platelet ratio ... See more keywords
Association of novel TMEM67 variants with mild phenotypes of high gamma‐glutamyl transpeptidase cholestasis and congenital hepatic fibrosis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30788
Abstract: TMEM67 (mecklin or MKS3) locates in the transition zone of cilia. Dysfunction of TMEM67 disrupts cilia‐related signaling and leads to developmental defects of multiple organs in humans. Typical autosomal recessive TMEM67 defects cause partial overlapping… read more here.
Keywords: cholestasis; tmem67 variants; tmem67; glutamyl transpeptidase ... See more keywords
Gamma‐Glutamyl Transferase Combined With Conventional Ultrasound Features in Diagnosing Biliary Atresia
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Ultrasound in Medicine"
DOI: 10.1002/jum.15968
Abstract: To develop and validate a biliary atresia (BA) diagnostic score based on serum gamma‐glutamyl transferase (GGT) levels and conventional ultrasound features for discriminating BA in patients with jaundice from two centers. read more here.
Keywords: glutamyl transferase; biliary atresia; ultrasound features; conventional ultrasound ... See more keywords
Ultrasound characteristics combined with gamma-glutamyl transpeptidase for diagnosis of biliary atresia in infants less than 30 days
Sign Up to like & getrecommendations! Published in 2021 at "Pediatric Surgery International"
DOI: 10.1007/s00383-021-04923-0
Abstract: To retrospectively assess the diagnostic performance of grey-scale ultrasound (US) characteristics and gamma-glutamyl transpeptidase (GGT) alone or combined in distinguishing biliary atresia (BA) from other cholestasis diseases in infants younger than 30 days. Between January… read more here.
Keywords: ultrasound characteristics; diagnosis; glutamyl transpeptidase; biliary atresia ... See more keywords
Statistical optimization of culture conditions of mesophillic gamma-glutamyl transpeptidase from Bacillus altitudinis IHB B1644
Sign Up to like & getrecommendations! Published in 2020 at "3 Biotech"
DOI: 10.1007/s13205-020-02252-y
Abstract: Microbial gamma-glutamyl transpeptidase (GGT) is a key enzyme in production of several γ-glutamyl compounds with food and pharmaceutical applications. Bacterial GGTs are not commercially available in the market owing to their low production from various… read more here.
Keywords: production; glutamyl transpeptidase; ggt; ihb b1644 ... See more keywords
Evaluation of gamma glutamyl transferase as a marker of cardiovascular risk, in 200 angiographically proven coronary artery disease patients
Sign Up to like & getrecommendations! Published in 2017 at "Indian Heart Journal"
DOI: 10.1016/j.ihj.2017.03.010
Abstract: Gamma glutamyl transferase (GGT) is emerging as a promising marker for assessing cardiovascular risk. GGT predicts cardiovascular mortality in the population and is positively associated with traditional risk factors for coronary artery disease (CAD). This… read more here.
Keywords: risk; coronary artery; ggt; cardiovascular risk ... See more keywords
Correlation between gamma-glutamyl transpeptidase activity and outcomes after Kasai portoenterostomy for biliary atresia.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of pediatric surgery"
DOI: 10.1016/j.jpedsurg.2017.10.001
Abstract: BACKGROUND/PURPOSE The role of serum gamma-glutamyl transpeptidase (GGT) levels in predicting clinical outcomes after Kasai portoenterostomy (KPE) is unknown. This study analyzed whether postoperative GGT along with the aspartate aminotransferase-to-platelet ratio index (APRi) predicted prognosis… read more here.
Keywords: glutamyl transpeptidase; month; biliary atresia; kasai portoenterostomy ... See more keywords
Quantitative Near-Infrared Photoacoustic Imaging of Gamma-Glutamyl Transpeptidase Activity in Tumors.
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DOI: 10.1021/acs.analchem.5c00112
Abstract: Gamma-glutamyl transpeptidase (GGT) is essential for glutathione metabolism and is overexpressed in many cancers, making its sensitive and quantitative detection crucial for early cancer diagnosis. However, existing imaging strategies often lack sufficient sensitivity and accuracy.… read more here.
Keywords: gamma glutamyl; activity; glutamyl transpeptidase; near infrared ... See more keywords
Impairment of gamma-glutamyl transferase 1 activity in the metabolic pathogenesis of chromophobe renal cell carcinoma
Sign Up to like & getrecommendations! Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1710849115
Abstract: Significance The mechanisms of chromophobe renal cell carcinoma (ChRCC) pathogenesis remain a key knowledge gap. Through metabolomics, this study uncovered a fundamental metabolic mechanism underlying the pathogenesis of ChRCC, with key therapeutic implications for this… read more here.
Keywords: renal cell; cell carcinoma; chrcc; chromophobe renal ... See more keywords