Treatment with a Gamma-Secretase Inhibitor Promotes Functional Recovery in Human iPSC- Derived Transplants for Chronic Spinal Cord Injury
Sign Up to like & getrecommendations! Published in 2018 at "Stem Cell Reports"
DOI: 10.1016/j.stemcr.2018.10.022
Abstract: Summary Treatment involving regenerative medicine for chronic spinal cord injury (SCI) is difficult due to phase-dependent changes in the intraspinal environment. We previously reported that treatment with a gamma-secretase inhibitor (GSI), which inhibits Notch signaling,… read more here.
Keywords: treatment; chronic spinal; gamma secretase; treatment gamma ... See more keywords
Design, Synthesis, and Evaluation of a Novel Series of Oxadiazine Gamma Secretase Modulators for Familial Alzheimer's Disease.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.6b01620
Abstract: Herein we describe the design, synthesis, and evaluation of a novel series of oxadiazine-based gamma secretase modulators obtained via isosteric amide replacement and critical consideration of conformational restriction. Oxadiazine lead 47 possesses good in vitro… read more here.
Keywords: design synthesis; evaluation novel; novel series; series oxadiazine ... See more keywords
A phase I/IIa safety and efficacy trial of intratympanic gamma-secretase inhibitor as a regenerative drug treatment for sensorineural hearing loss
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-45784-0
Abstract: Inhibition of Notch signalling with a gamma-secretase inhibitor (GSI) induces mammalian hair cell regeneration and partial hearing restoration. In this proof-of-concept Phase I/IIa multiple-ascending dose open-label trial (ISRCTN59733689), adults with mild-moderate sensorineural hearing loss received… read more here.
Keywords: gamma secretase; hearing; phase iia; secretase inhibitor ... See more keywords
Gamma secretase inhibitors: a patent review (2013 - 2015)
Sign Up to like & getrecommendations! Published in 2017 at "Expert Opinion on Therapeutic Patents"
DOI: 10.1080/13543776.2017.1313231
Abstract: ABSTRACT Introduction: Gamma secretase (GS) is an intricate and multi-subunits complex, and it can cut various transmembrane proteins. Now it is a therapeutic target for a number of diseases. However, due to some side effects,… read more here.
Keywords: 2013 2015; secretase inhibitors; gamma secretase; review ... See more keywords
Repurposing nirogacestat, a gamma secretase enzyme inhibitor in desmoid tumors
Sign Up to like & getrecommendations! Published in 2025 at "Future Oncology"
DOI: 10.1080/14796694.2025.2550826
Abstract: ABSTRACT The gamma secretase (GS) enzyme controls cell–cell adhesion, neural stem cell proliferation, neo-angiogenesis, spinal maturation, and metabolism of amyloid precursor proteins (APP). Pathological production of abnormal amyloid-beta isoforms and senile plaques serves as the… read more here.
Keywords: secretase enzyme; gamma secretase; desmoid tumors;
Rutin Potentially Binds the Gamma Secretase Catalytic Site, Down Regulates the Notch Signaling Pathway and Reduces Sphere Formation in Colonospheres
Sign Up to like & getrecommendations! Published in 2022 at "Metabolites"
DOI: 10.3390/metabo12100926
Abstract: Rutin, a natural flavonol, can modulate molecular signaling pathways and has considerable potential in cancer treatment. However, little is known about the effect of rutin on the notch signaling pathway (NSP) in cancer and cancer… read more here.
Keywords: notch signaling; signaling pathway; gamma secretase; catalytic site ... See more keywords