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   Articles with "gammaherpesvirus" as a keyword



A replication-deficient gammaherpesvirus vaccine protects mice from lytic disease and reduces latency establishment

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recommendations! Published in 2024 at "NPJ Vaccines"

DOI: 10.1038/s41541-024-00908-x

Abstract: Gammaherpesviruses are oncogenic viruses that establish lifelong infections and are significant causes of morbidity and mortality. Vaccine strategies to limit gammaherpesvirus infection and disease are in development, but there are no FDA-approved vaccines for Epstein-Barr… read more here.

Keywords: replication; gammaherpesvirus; disease; replication deficient ... See more keywords

A Conserved Leucine Zipper Motif in Gammaherpesvirus ORF52 Is Critical for Distinct Microtubule Rearrangements

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recommendations! Published in 2017 at "Journal of Virology"

DOI: 10.1128/jvi.00304-17

Abstract: ABSTRACT Productive viral infection often depends on the manipulation of the cytoskeleton. Herpesviruses, including rhesus monkey rhadinovirus (RRV) and its close homolog, the oncogenic human gammaherpesvirus Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 (KSHV/HHV8), exploit microtubule (MT)-based… read more here.

Keywords: microtubule; leucine zipper; gammaherpesvirus; infection ... See more keywords

Apolipoprotein E selectively supports gammaherpesvirus replication in macrophages

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recommendations! Published in 2025 at "Journal of Virology"

DOI: 10.1128/jvi.00480-25

Abstract: ABSTRACT Gammaherpesviruses establish lifelong infections in over 90% of adults worldwide and contribute to the development of several cancers. Endogenous lipid synthesis pathways support lytic and latent life cycles of several gammaherpesviruses. However, the role… read more here.

Keywords: replication; gammaherpesvirus; role; gammaherpesvirus infection ... See more keywords

The Antagonism between the Murine Gammaherpesvirus Protein Kinase and Global Interferon Regulatory Factor 1 Expression Shapes the Establishment of Chronic Infection

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recommendations! Published in 2022 at "Journal of Virology"

DOI: 10.1128/jvi.01260-22

Abstract: Gammaherpesviruses are prevalent pathogens that manipulate physiological B cell differentiation to establish lifelong infection. This manipulation is also involved in gammaherpesvirus-driven B cell lymphomas, as differentiation of latently infected B cells through the germinal center… read more here.

Keywords: cell; protein kinase; infection; germinal center ... See more keywords

Interferon Regulatory Factor 7 Attenuates Chronic Gammaherpesvirus Infection

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recommendations! Published in 2020 at "Journal of Virology"

DOI: 10.1128/jvi.01554-20

Abstract: The innate immune system of the host is critical for the restriction of acute viral infections. In contrast, the role of the innate immune network during chronic herpesvirus infection remains poorly defined. Interferon regulatory factor… read more here.

Keywords: role irf; infection; factor; gammaherpesvirus ... See more keywords

Gammaherpesvirus RNAs Come Full Circle

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recommendations! Published in 2019 at "mBio"

DOI: 10.1128/mbio.00071-19

Abstract: After an adaptive immune response is mounted, gammaherpesviruses achieve persistence through the utilization of viral noncoding RNAs to craft a suitable host cell environment in an immunologically transparent manner. While gammaherpesvirus long noncoding RNAs (lncRNAs)… read more here.

Keywords: come full; gammaherpesvirus rnas; viral noncoding; noncoding rnas ... See more keywords

A new era in gammaherpesvirus transcriptomics: high-resolution profiling and model development

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recommendations! Published in 2025 at "mSystems"

DOI: 10.1128/msystems.00208-25

Abstract: ABSTRACT A recent article by Torma et al. (G. Torma, Á. Dörmő, Á. Fülöp, D. Tombácz, et al., mSystems 10:e01678-24, 2025, https://doi.org/10.1128/msystems.01678-24) presents the first high-resolution, long-read transcriptomic atlas of Caviid gammaherpesvirus 1 (CaGHV-1), offering… read more here.

Keywords: gammaherpesvirus; new era; resolution; model ... See more keywords

Long-read transcriptomics of caviid gammaherpesvirus 1: compiling a comprehensive RNA atlas

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recommendations! Published in 2025 at "mSystems"

DOI: 10.1128/msystems.01678-24

Abstract: ABSTRACT Caviid gammaherpesvirus 1 (CaGHV-1), formerly known as the guinea pig herpes-like virus, is an oncogenic gammaherpesvirus with a sequenced genome but an as-yet uncharacterized transcriptome. Using nanopore long-read RNA sequencing, we annotated the CaGHV-1… read more here.

Keywords: non coding; gammaherpesvirus; long read; caviid gammaherpesvirus ... See more keywords

Predator-prey transmission of a gammaherpesvirus from Asian badgers (Meles leucurus) to endangered Amur tigers (Panthera tigris altaica)

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recommendations! Published in 2025 at "PLOS One"

DOI: 10.1371/journal.pone.0327463

Abstract: We sought to identify herpesviruses in wild Amur tigers (Panthera tigris altaica) of the Russian Far East in and near the Sikhote-Alin Biosphere Zapovednik protected area. We used multiple herpesvirus consensus PCRs targeting the glycoprotein… read more here.

Keywords: asian badgers; badgers meles; gammaherpesvirus; amur tigers ... See more keywords

Multidimensional analysis of Gammaherpesvirus RNA expression reveals unexpected heterogeneity of gene expression

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recommendations! Published in 2019 at "PLoS Pathogens"

DOI: 10.1371/journal.ppat.1007849

Abstract: Virus-host interactions are frequently studied in bulk cell populations, obscuring cell-to-cell variation. Here we investigate endogenous herpesvirus gene expression at the single-cell level, combining a sensitive and robust fluorescent in situ hybridization platform with multiparameter… read more here.

Keywords: gammaherpesvirus; infection; gene expression; expression ... See more keywords

The Critical Role of Genome Maintenance Proteins in Immune Evasion During Gammaherpesvirus Latency

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recommendations! Published in 2019 at "Frontiers in Microbiology"

DOI: 10.3389/fmicb.2018.03315

Abstract: Gammaherpesviruses are important pathogens that establish latent infection in their natural host for lifelong persistence. During latency, the viral genome persists in the nucleus of infected cells as a circular episomal element while the viral… read more here.

Keywords: gammaherpesvirus; genome maintenance; latency; immune evasion ... See more keywords