A Conserved Leucine Zipper Motif in Gammaherpesvirus ORF52 Is Critical for Distinct Microtubule Rearrangements
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Virology"
DOI: 10.1128/jvi.00304-17
Abstract: ABSTRACT Productive viral infection often depends on the manipulation of the cytoskeleton. Herpesviruses, including rhesus monkey rhadinovirus (RRV) and its close homolog, the oncogenic human gammaherpesvirus Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 (KSHV/HHV8), exploit microtubule (MT)-based… read more here.
Keywords: microtubule; leucine zipper; gammaherpesvirus; infection ... See more keywords
The Antagonism between the Murine Gammaherpesvirus Protein Kinase and Global Interferon Regulatory Factor 1 Expression Shapes the Establishment of Chronic Infection
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.01260-22
Abstract: Gammaherpesviruses are prevalent pathogens that manipulate physiological B cell differentiation to establish lifelong infection. This manipulation is also involved in gammaherpesvirus-driven B cell lymphomas, as differentiation of latently infected B cells through the germinal center… read more here.
Keywords: cell; protein kinase; infection; germinal center ... See more keywords
Interferon Regulatory Factor 7 Attenuates Chronic Gammaherpesvirus Infection
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DOI: 10.1128/jvi.01554-20
Abstract: The innate immune system of the host is critical for the restriction of acute viral infections. In contrast, the role of the innate immune network during chronic herpesvirus infection remains poorly defined. Interferon regulatory factor… read more here.
Keywords: role irf; infection; factor; gammaherpesvirus ... See more keywords
Gammaherpesvirus RNAs Come Full Circle
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DOI: 10.1128/mbio.00071-19
Abstract: After an adaptive immune response is mounted, gammaherpesviruses achieve persistence through the utilization of viral noncoding RNAs to craft a suitable host cell environment in an immunologically transparent manner. While gammaherpesvirus long noncoding RNAs (lncRNAs)… read more here.
Keywords: come full; gammaherpesvirus rnas; viral noncoding; noncoding rnas ... See more keywords
Multidimensional analysis of Gammaherpesvirus RNA expression reveals unexpected heterogeneity of gene expression
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DOI: 10.1371/journal.ppat.1007849
Abstract: Virus-host interactions are frequently studied in bulk cell populations, obscuring cell-to-cell variation. Here we investigate endogenous herpesvirus gene expression at the single-cell level, combining a sensitive and robust fluorescent in situ hybridization platform with multiparameter… read more here.
Keywords: gammaherpesvirus; infection; gene expression; expression ... See more keywords
The Critical Role of Genome Maintenance Proteins in Immune Evasion During Gammaherpesvirus Latency
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DOI: 10.3389/fmicb.2018.03315
Abstract: Gammaherpesviruses are important pathogens that establish latent infection in their natural host for lifelong persistence. During latency, the viral genome persists in the nucleus of infected cells as a circular episomal element while the viral… read more here.
Keywords: gammaherpesvirus; genome maintenance; latency; immune evasion ... See more keywords
Oropharyngeal Shedding of Gammaherpesvirus DNA by Cats, and Natural Infection of Salivary Epithelium
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DOI: 10.3390/v14030566
Abstract: Felis catus gammaherpesvirus-1 (FcaGHV1), a novel candidate oncogenic virus, infects cats worldwide. Whether the oropharynx is a site of virus shedding and persistence, and whether oronasal carcinomas harbor FcaGHV1 nucleic acid were investigated. In a… read more here.
Keywords: oropharyngeal shedding; dna; epithelium; fcaghv1 ... See more keywords
Latent gammaherpesvirus exacerbates arthritis through modification of age-associated B cells
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DOI: 10.7554/elife.67024
Abstract: Epstein-Barr virus (EBV) infection is associated with rheumatoid arthritis (RA) in adults, though the nature of the relationship remains unknown. Herein, we have examined the contribution of viral infection to the severity of arthritis in… read more here.
Keywords: latent gammaherpesvirus; associated cells; age associated; infection ... See more keywords