Hepatoprotective effects of semaglutide, lanifibranor and dietary intervention in the GAN diet‐induced obese and biopsy‐confirmed mouse model of NASH
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DOI: 10.1111/cts.13235
Abstract: Non‐alcoholic steatohepatitis (NASH) has emerged as a major challenge for public health because of high global prevalence and lack of evidence‐based therapies. Most animal models of NASH lack sufficient validation regarding disease progression and pharmacological… read more here.
Keywords: dietary intervention; nash; gan diet; gan dio ... See more keywords
Human translatability of the GAN diet-induced obese mouse model of non-alcoholic steatohepatitis
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DOI: 10.1186/s12876-020-01356-2
Abstract: Background Animal models of non-alcoholic steatohepatitis (NASH) are important tools in preclinical research and drug discovery. Gubra-Amylin NASH (GAN) diet-induced obese (DIO) mice represent a model of fibrosing NASH. The present study directly assessed the… read more here.
Keywords: dio nash; model; gan dio; nash ... See more keywords