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   Articles with "ganaxolone" as a keyword



Intravenous Ganaxolone: Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability in Healthy Adults

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recommendations! Published in 2024 at "Clinical Pharmacology in Drug Development"

DOI: 10.1002/cpdd.1365

Abstract: Ganaxolone, a neuroactive steroid anticonvulsant that modulates both synaptic and extrasynaptic γ‐aminobutyric acid type A (GABAA) receptors, is in development for treatment of status epilepticus (SE) and rare epileptic disorders, and has been approved in… read more here.

Keywords: bolus; ganaxolone; pharmacodynamics safety; pharmacokinetics pharmacodynamics ... See more keywords

The efficacy and safety of ganaxolone for the treatment of refractory epilepsy: A meta‐analysis from randomized controlled trials

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recommendations! Published in 2022 at "Epilepsia Open"

DOI: 10.1002/epi4.12669

Abstract: Epilepsy is one of the most common and refractory neurological disorders globally. Ganaxolone, a neuroactive steroid that enhances GABAergic inhibition, has been tested in many trials for the resolution of refractory epilepsy. Based on these,… read more here.

Keywords: ganaxolone; refractory; meta analysis; refractory epilepsy ... See more keywords

An overview of ganaxolone as a treatment for seizures associated with cyclin-dependent kinase-like 5 deficiency disorder

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recommendations! Published in 2024 at "Expert Review of Neurotherapeutics"

DOI: 10.1080/14737175.2024.2385937

Abstract: ABSTRACT Introduction Cyclin-dependent kinase-Like 5 (CDKL5) deficiency disorder (CDD) is a rare neurodevelopmental condition commonly characterized by drug-resistant, refractory epilepsy, and seizures beginning in infancy. Most patients use multiple drugs, yet seizures remain difficult to… read more here.

Keywords: cyclin dependent; kinase like; ganaxolone; dependent kinase ... See more keywords

Ganaxolone: A New Treatment for CDKL5 Deficiency Disorder

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recommendations! Published in 2022 at "Epilepsy Currents"

DOI: 10.1177/15357597221125238

Abstract: Safety and Efficacy of Ganaxolone in Patients With CDKL5 Deficiency Disorder: Results From the Double-Blind Phase of a Randomised, Placebo-Controlled, Phase 3 Trial Knight EMP, Amin S, Bahi-Buisson N, Benke TA, Cross JH, Demarest ST,… read more here.

Keywords: ganaxolone group; ganaxolone; trial; group ... See more keywords

Examining Neurosteroid-Analogue Therapy in the Preterm Neonate For Promoting Hippocampal Neurodevelopment

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recommendations! Published in 2022 at "Frontiers in Physiology"

DOI: 10.3389/fphys.2022.871265

Abstract: Background: Preterm birth can lead to brain injury and currently there are no targeted therapies to promote postnatal brain development and protect these vulnerable neonates. We have previously shown that the neurosteroid-analogue ganaxolone promotes white… read more here.

Keywords: ganaxolone; neurosteroid analogue; preterm; brain ... See more keywords