Complex Metabolism of the Novel Neurosteroid, Ganaxolone, in Humans: A Unique Challenge for Metabolites in Safety Testing Assessment
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DOI: 10.1124/dmd.122.001218
Abstract: The human pharmacokinetics, metabolism, and excretion of [14C]-ganaxolone (GNX) were characterized in healthy male subjects (n = 8) following a single 300-mg (150 μCi) oral dose. GNX exhibited a short half-life of 4 hours in… read more here.
Keywords: metabolism; ganaxolone humans; spectroscopy; chemistry ... See more keywords