The interaction of Aβ42 peptide in monomer, oligomer or fibril forms with sphingomyelin/cholesterol/ganglioside bilayers.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.11.112
Abstract: Aβ42 peptide binds neuronal membranes and aggregates into plaques that are characteristic of Alzheimer's disease. Aβ42 peptide has been proposed to be generated in membrane (nano) domains in the liquid-ordered phase, ganglioside GM1 being a… read more here.
Keywords: peptide; oligomer fibril; ganglioside; monomer oligomer ... See more keywords
Effect of ganglioside combined with Chip Jiaji electro-acupuncture on Nogo-NgR signal pathway in SCI rats
Sign Up to like & getrecommendations! Published in 2021 at "Saudi Journal of Biological Sciences"
DOI: 10.1016/j.sjbs.2021.02.031
Abstract: At present, the effect of ganglioside combined with Jiaji electroacupuncture (Jiaji EA) on SCI still remains unclear. This study explores the effect of ganglioside combined with electroacupuncture on Nogo/NgR signal pathway in spinal cord tissue… read more here.
Keywords: ganglioside combined; ganglioside; group; effect ... See more keywords
Combinatory data independent acquisition and parallel reaction monitoring method for deep profiling of gangliosides.
Sign Up to like & getrecommendations! Published in 2020 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.0c02313
Abstract: Ganglioside is an important class of lipid species involving in intercellular signaling and various diseases, especially for neurodegenerative diseases. Systematic ganglioside profiling is challenging due to their naturally low abundance and highly diverse species. Herein,… read more here.
Keywords: data independent; ganglioside species; ganglioside; independent acquisition ... See more keywords
Total Synthesis of the Echinodermatous Ganglioside LLG-3 Possessing the Biological Function of Promoting the Neurite Outgrowth.
Sign Up to like & getrecommendations! Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.0c02692
Abstract: A total synthesis of echinodermatous ganglioside LLG-3 with neuritogenic activity was accomplished by a convergent strategy. The synthesis of 2-hydroxyethyl 8-O-Me-α-sialoside 2 was started from the phenyl 7,8-di-O-Pico-thiosialoside 5, which can be chemoselectively removed the… read more here.
Keywords: ganglioside; synthesis echinodermatous; total synthesis; ganglioside llg ... See more keywords
Autophagy-dependent removal of α-synuclein: a novel mechanism of GM1 ganglioside neuroprotection against Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2020 at "Acta Pharmacologica Sinica"
DOI: 10.1038/s41401-020-0454-y
Abstract: GM1 ganglioside is particularly abundant in the mammalian central nervous system and has shown beneficial effects on neurodegenerative diseases. In this study, we investigated the therapeutic effect of GM1 ganglioside in experimental models of Parkinson’s… read more here.
Keywords: autophagy dependent; ganglioside; gm1 ganglioside; syn a53t ... See more keywords
Responsibility of lipid compositions for the amyloid ß assembly induced by ganglioside nanoclusters in mouse synaptosomal membranes
Sign Up to like & getrecommendations! Published in 2018 at "Polymer Journal"
DOI: 10.1038/s41428-018-0041-y
Abstract: AbstractThe assembly of amyloid ß protein (Aß) on ganglioside-enriched microdomains in presynaptic neuronal membranes is involved in the onset of Alzheimer’s disease. We previously found that a highly enriched ganglioside domain generated in a reconstituted… read more here.
Keywords: neuronal membranes; gm3; lipid compositions; ganglioside ... See more keywords
A low-carbohydrate ketogenic diet promotes ganglioside synthesis via the transcriptional regulation of ganglioside metabolism-related genes
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-43952-7
Abstract: Low-carbohydrate ketogenic diets (LCKDs) are used for treating obesity and epilepsy; however, the molecular mechanism of LCKDs in tissues has not been fully investigated. In this study, novel LCKD-associated molecular targets were explored using gene… read more here.
Keywords: ganglioside; ganglioside synthesis; expression; low carbohydrate ... See more keywords
Antitumor effects of the GM3(Neu5Gc) ganglioside-specific humanized antibody 14F7hT against Cmah-transfected cancer cells
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-46148-1
Abstract: The GM3(Neu5Gc) ganglioside represents a tumor-specific antigen that is considered a promising target for cancer immunotherapy. We previously demonstrated that the humanized antibody 14F7hT, specific for this ganglioside, exhibited significant antitumor effects in preclinical hematological… read more here.
Keywords: gm3 neu5gc; ganglioside; antibody; antitumor effects ... See more keywords
Genistein prevents the decrease in ganglioside levels induced by amyloid-beta in the frontal cortex of rats
Sign Up to like & getrecommendations! Published in 2022 at "Neurological Research"
DOI: 10.1080/01616412.2021.2024731
Abstract: ABSTRACT Objectives In this study, an in vivo model of Aβ toxicity was used to investigate the effects of this peptide and the treatment with genistein on the lipid composition (gangliosides, phospholipids and cholesterol) in… read more here.
Keywords: ganglioside; ganglioside levels; decrease ganglioside; cortex rats ... See more keywords
GQ1b-Seronegative Miller Fisher Syndrome Associated With Pembrolizumab.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuro-Ophthalmology"
DOI: 10.1097/wno.0000000000000755
Abstract: A 62-year-old man with a history of metastatic squamous cell carcinoma (SCC) of the scalp, who recently completed 5 cycles of pembrolizumab, presented to the emergency department with 2 weeks of progressive gait ataxia, dysarthria,… read more here.
Keywords: fisher syndrome; ophthalmology; miller fisher; pembrolizumab ... See more keywords
Imaging mass spectrometry identifies prognostic ganglioside species in rodent intracranial transplants of glioma and medulloblastoma
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0176254
Abstract: Matrix-assisted laser desorption ionization (MALDI) imaging mass spectrometry (MALDI-MSI) allows us to investigate the distribution of lipid molecules within tissues. We used MALDI-MSI to identify prognostic gangliosides in tissue sections of rat intracranial allografts of… read more here.
Keywords: mass spectrometry; ganglioside; imaging mass; medulloblastoma ... See more keywords