The human anti-ganglioside GM1 autoantibody response following traumatic and surgical central nervous system insults
Sign Up to like & getrecommendations! Published in 2022 at "Neuroscience research"
DOI: 10.1016/j.neures.2022.03.009
Abstract: Predictors of the central nervous system (CNS) directed autoantibody response after acute CNS injury are poorly understood. We analyzed titers of IgG and IgM autoantibodies to ganglioside GM1 in serial serum specimens collected from human… read more here.
Keywords: central nervous; response; ganglioside gm1; nervous system ... See more keywords
Diseaseâmodifying effects of ganglioside GM1 in Huntington's disease models
Sign Up to like & getrecommendations! Published in 2017 at "EMBO Molecular Medicine"
DOI: 10.15252/emmm.201707763
Abstract: Huntington's disease (HD) is a progressive neurodegenerative disorder characterized by motor, cognitive and psychiatric problems. Previous studies indicated that levels of brain gangliosides are lower than normal in HD models and that administration of exogenous… read more here.
Keywords: administration; huntington disease; ganglioside gm1; disease modifying ... See more keywords
Design, synthesis and neurite outgrowth activity of novel ganglioside GM1 derivatives by remodeling of the fatty acid moiety.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of medicinal chemistry"
DOI: 10.2139/ssrn.4141761
Abstract: Ganglioside GM1 is a glycosphingolipid found on mammalian cell membranes, and it is involved in ischemic encephalopathy, spinal cord injury and neurodegenerative diseases. Fatty acids, as a structure module of GM1, have been reported to… read more here.
Keywords: ganglioside gm1; gm1 derivatives; activity; neurite outgrowth ... See more keywords
Ganglioside GM1 and the Central Nervous System
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24119558
Abstract: GM1 is one of the major glycosphingolipids (GSLs) on the cell surface in the central nervous system (CNS). Its expression level, distribution pattern, and lipid composition are dependent upon cell and tissue type, developmental stage,… read more here.
Keywords: ganglioside gm1; gm1 central; disease; central nervous ... See more keywords
Preparation of Ganglioside GM1 by Supercritical CO2 Extraction and Immobilized Sialidase
Sign Up to like & getrecommendations! Published in 2019 at "Molecules"
DOI: 10.3390/molecules24203732
Abstract: Monosialotetrahexosylganglioside (GM1) has good activity on brain diseases and was developed to be a drug applied in clinics for neurological disorders and nerve injury. It is difficult to isolate GM1 in industry scale from the… read more here.
Keywords: extraction; supercritical co2; ganglioside gm1; preparation ganglioside ... See more keywords