Tumor Suppressor Down-Regulation Promotes Hepatocyte Proliferation: A New GANKster on the Block
Sign Up to like & getrecommendations! Published in 2018 at "Cellular and Molecular Gastroenterology and Hepatology"
DOI: 10.1016/j.jcmgh.2018.06.003
Abstract: epatocellular carcinoma (HCC) is ranked as the Hsixth most common neoplasm and the third leading cause of cancer death worldwide. HCC incidence is expected to continue to increase in many regions of the world. HCC… read more here.
Keywords: tumor suppressor; gastroenterology; proliferation; gankyrin ... See more keywords
Small-Molecule Gankyrin Inhibition as a Therapeutic Strategy for Breast and Lung Cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00190
Abstract: Gankyrin is an oncoprotein responsible for the development of numerous cancer types. It regulates the expression levels of multiple tumor suppressor proteins (TSPs) in liver cancer; however, gankyrin's regulation of these TSPs in breast and… read more here.
Keywords: small molecule; gankyrin; cancer; breast lung ... See more keywords
Gankyrin induces STAT3 activation in tumor microenvironment and sorafenib resistance in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Science"
DOI: 10.1111/cas.13341
Abstract: Most hepatocellular carcinomas (HCC) develop as a result of chronic liver inflammation. We have shown that the oncoprotein gankyrin is critical for inflammationâinduced tumorigenesis in the colon. Although the in vitro function of gankyrin is… read more here.
Keywords: parenchymal cells; expression; tumor microenvironment; gankyrin ... See more keywords
Helicobacter pylori and Epstein-Barr Virus Coinfection Stimulates Aggressiveness in Gastric Cancer through the Regulation of Gankyrin
Sign Up to like & getrecommendations! Published in 2021 at "mSphere"
DOI: 10.1128/msphere.00751-21
Abstract: In the present study, we evaluated the synergistic effects of EBV and H. pylori infection on gastric epithelial cells in various coinfection models. These coinfection models were among the first to depict the exposures of… read more here.
Keywords: pylori; epithelial cells; ebv pylori; gastric epithelial ... See more keywords
Gankyrin Contributes to Tumorigenesis and Chemoresistance in Sporadic Colorectal Cancer
Sign Up to like & getrecommendations! Published in 2018 at "Digestion"
DOI: 10.1159/000494969
Abstract: Background: Although Gankyrin is overexpressed in many malignancies, the role of Gankyrin for tumorigenesis and chemoresistance remains to be elucidated in sporadic colorectal cancer (CRC). Aims: We investigate whether Gankyrin affects Adenomatous polyposis coli (Apc)… read more here.
Keywords: colorectal cancer; expression; sporadic colorectal; tumorigenesis chemoresistance ... See more keywords
Gankyrin has a potential role in embryo implantation via activation of STAT3.
Sign Up to like & getrecommendations! Published in 2022 at "Reproduction"
DOI: 10.1530/rep-21-0199
Abstract: Embryo implantation, a critical step during the mammalian reproductive process, requires normal developing blastocysts and a receptive endometrium. Endometriosis, a common pathologically benign gynecological condition, is associated with decreased fertility and reduced endometrial receptivity. The… read more here.
Keywords: activation; role; gankyrin; implantation ... See more keywords