Retracted: Ganoderic Acid A exerts the cytoprotection against hypoxia‐triggered impairment in PC12 cells via elevating microRNA‐153
Sign Up to like & getrecommendations! Published in 2019 at "Phytotherapy Research"
DOI: 10.1002/ptr.6556
Abstract: Ganoderic Acid A (GAA) is often applied for healing cardiovascular and cerebrovascular ailments, but the influences in cerebral ischemia injury are still hazy. The research delved into the functions of GAA in hypoxia‐triggered impairment in… read more here.
Keywords: ganoderic acid; pc12 cells; mir 153; hypoxia ... See more keywords
Antioxidant potential of ganoderic acid in Notch-1 protein in neuroblastoma
Sign Up to like & getrecommendations! Published in 2018 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-018-3485-7
Abstract: Neuroblastoma is a childhood tumor arising from developing a sympathetic nervous system and causes around 10% of pediatric tumors. Despite advancement in the use of sophisticated techniques in molecular biology, neuroblastoma patient’s survivability rate is… read more here.
Keywords: ganoderic acid; kcal mol; acid notch; acid ... See more keywords
Protective effect of Ganoderic acid A on adjuvant-induced arthritis.
Sign Up to like & getrecommendations! Published in 2020 at "Immunology letters"
DOI: 10.1016/j.imlet.2020.06.010
Abstract: The purpose of the experiment was to study the effect of Ganoderic acid A (GAA) on adjuvant-induced arthritis in rats. In this study, the rat model of collagen-induced rheumatoid arthritis (CIA) was established with type… read more here.
Keywords: ganoderic acid; pathology; effect; effect ganoderic ... See more keywords
Ganoderic acid alleviates chemotherapy-induced fatigue in mice bearing colon tumor.
Sign Up to like & getrecommendations! Published in 2021 at "Acta pharmacologica Sinica"
DOI: 10.1038/s41401-021-00669-6
Abstract: Chemotherapy-related fatigue (CRF) is increasingly being recognized as one of the severe symptoms in patients undergoing chemotherapy, which not only largely reduces the quality of life in patients, but also diminishes their physical and social… read more here.
Keywords: chemotherapy; ganoderic acid; fatigue; mice ... See more keywords
Ganoderic Acid A alleviates the degeneration of intervertebral disc via suppressing the activation of TLR4/NLRP3 signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2070996
Abstract: ABSTRACT As a multifactorial disease, intervertebral disc degeneration (IVDD) causes many spinal-related diseases, which causes disability in the workforce and heavy social costs all over the world. Recently, Ganoderic Acid A (GAA) has been reported… read more here.
Keywords: activation tlr4; nlrp3 signaling; ganoderic acid; intervertebral disc ... See more keywords
Transcriptome dynamics and metabolite analysis revealed the candidate genes and regulatory mechanism of ganoderic acid biosynthesis during liquid superficial‐static culture of Ganoderma lucidum
Sign Up to like & getrecommendations! Published in 2020 at "Microbial Biotechnology"
DOI: 10.1111/1751-7915.13670
Abstract: Ganoderic acid (GA), an important secondary metabolite of Ganoderma lucidum, exhibited many significant pharmacological activities. In this study, the biosynthetic mechanism of GAs was investigated by comparing metabolites and transcriptome dynamics during liquid superficial‐static culture… read more here.
Keywords: biosynthesis; ganoderic acid; gas; transcriptome dynamics ... See more keywords
Cross Talk between Nitric Oxide and Calcium-Calmodulin Regulates Ganoderic Acid Biosynthesis in Ganoderma lucidum under Heat Stress
Sign Up to like & getrecommendations! Published in 2018 at "Applied and Environmental Microbiology"
DOI: 10.1128/aem.00043-18
Abstract: ABSTRACT We previously reported that high temperature impacts ganoderic acid (GA) biosynthesis in Ganoderma lucidum via Ca2+. Therefore, to further understand the signal-regulating network of the organism's response to heat stress (HS), we examined the… read more here.
Keywords: biosynthesis; ganoderic acid; response; lucidum ... See more keywords
Triterpenes and Soluble Polysaccharide Changes in Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), During Fruiting Growth.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of medicinal mushrooms"
DOI: 10.1615/intjmedmushrooms.2018027357
Abstract: We analyzed the changes in triterpenes and soluble polysaccharides in Ganoderma lucidum strain G0119 during 4 growth phases in 3 regions of the fruiting bodies using reversed-phase high-performance liquid chromatography, and we also analyzed the… read more here.
Keywords: phase; ganoderic acid; triterpenes soluble; soluble polysaccharides ... See more keywords
In Silico Investigation of Ganoderic Acid A Targeting Amyloid-Beta and Tau Protein Aggregation in Alzheimer's Disease.
Sign Up to like & getrecommendations! Published in 2025 at "International journal of medicinal mushrooms"
DOI: 10.1615/intjmedmushrooms.2025059137
Abstract: Alzheimer's disease (AD) represents a significant challenge in neurodegenerative disorders, characterized by the accumulation of amyloid-beta (Aβ) plaques and tau protein tangles in the brain. Current treatments provide symptomatic relief but do not halt disease… read more here.
Keywords: acid; tau protein; ganoderic acid; disease ... See more keywords
Integrated Whole-Transcriptome Profiling and Bioinformatics Analysis of the Polypharmacological Effects of Ganoderic Acid Me in Colorectal Cancer Treatment
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.833375
Abstract: Ganoderic acid Me (GA-Me) is a natural bioactive compound derived from Ganoderma lucidum. Our present results suggested that GA-Me inhibited proliferation, induced DNA fragmentation and significantly activated caspase-9 and caspase-3 in HCT116 cells. As shown… read more here.
Keywords: hsa mir; treatment; cancer; ganoderic acid ... See more keywords
Ganoderic Acid A Metabolites and Their Metabolic Kinetics
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2017.00101
Abstract: Ganoderic acid A (GAA), a representative active triterpenoid from Ganoderma lucidum, has been reported to exhibit antinociceptive, antioxidative, cytotoxic, hepatoprotective and anticancer activities. The present study aims (1) to identify GAA metabolites, in vivo by… read more here.
Keywords: metabolites metabolic; ganoderic acid; acid metabolites; gaa ... See more keywords