Concomitant targeting of Hedgehog signaling and MCL-1 synergistically induces cell death in Hedgehog-driven cancer cells.
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DOI: 10.1016/j.canlet.2019.08.012
Abstract: In the present study, we show that concomitant inhibition of Hedgehog (HH) signaling by the Glioma-Associated Oncogene Homolog1 (GLI1)-targeting agent GANT61 and the antiapoptotic BCL-2 protein family member MCL-1 by A-1210477 synergistically induces cell death… read more here.
Keywords: death; hedgehog; gant61 1210477; cell death ... See more keywords