Gap-134, a Connexin43 activator, prevents age-related development of ventricular fibrosis in Scn5a+/- mice.
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DOI: 10.1016/j.phrs.2020.104922
Abstract: Down-regulation of Connexin43 (Cx43) has often been associated with the development of cardiac fibrosis. We showed previously that Scn5a heterozygous knockout mice (Scn5a+/-), which mimic familial progressive cardiac conduction defect, exhibit an age-dependent decrease of… read more here.
Keywords: gap 134; fibrosis; age; scn5a ... See more keywords