Subcellular reorganization and altered phosphorylation of the astrocytic gap junction protein connexin43 in human and experimental temporal lobe epilepsy
Sign Up to like & getrecommendations! Published in 2017 at "Glia"
DOI: 10.1002/glia.23196
Abstract: Dysfunctional astrocytes are increasingly recognized as key players in the development and progression of mesial temporal lobe epilepsy (MTLE). One of the dramatic changes astrocytes undergo in MTLE with hippocampal sclerosis (HS) is loss of… read more here.
Keywords: gap; gap junction; astrocytic gap; phosphorylation ... See more keywords
Gap junction channels as potential targets for the treatment of major depressive disorder
Sign Up to like & getrecommendations! Published in 2017 at "Psychopharmacology"
DOI: 10.1007/s00213-017-4782-7
Abstract: BackgroundMajor depressive disorder (MDD) remains a major public health problem worldwide. The association between MDD and the dysfunction of gap junction channels (GJCs) in glial cells, especially astrocytes, is still controversial.ObjectiveThis review provides an overview… read more here.
Keywords: treatment; gap junction; depressive disorder; junction channels ... See more keywords
Enhanced gap junction intercellular communication inhibits catabolic and pro-inflammatory responses in tenocytes against heat stress
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cell Communication and Signaling"
DOI: 10.1007/s12079-017-0397-3
Abstract: Elevation of tendon core temperature during severe activity is well known. However, its effects on tenocyte function have not been studied in detail. The present study tested a hypothesis that heat stimulation upregulates tenocyte catabolism,… read more here.
Keywords: junction intercellular; communication; gap junction; intercellular communication ... See more keywords
Expression and functional regulation of gap junction protein connexin 43 in dermal mesenchymal stem cells from psoriasis patients.
Sign Up to like & getrecommendations! Published in 2020 at "Acta histochemica"
DOI: 10.1016/j.acthis.2020.151550
Abstract: BACKGROUND Psoriasis is a chronic recurrent inflammatory disease. Mesenchymal stem cells (MSCs) can regulate the inflammatory microenvironment, thereby controlling the proliferation, differentiation, and migration of immune cells. Connexin 43(Cx43), a key gap junction protein, has… read more here.
Keywords: psoriasis; dmscs; gap junction; cx43 ... See more keywords
Vitamin D receptor and metabolite effects on corneal epithelial cell gap junction proteins.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental eye research"
DOI: 10.1016/j.exer.2019.107776
Abstract: Vitamin D is a fat-soluble prohormone that can be activated both systemically and within individual tissues. Our lab has previously demonstrated that the corneal epithelium can activate vitamin D and that the vitamin D metabolites… read more here.
Keywords: gap; gap junction; corneal epithelial; 24r 2d3 ... See more keywords
Genome-wide characterization of gap junction (connexins and pannexins) genes in turbot (Scophthalmus maximus L.): evolution and immune response following Vibrio anguillarum infection.
Sign Up to like & getrecommendations! Published in 2021 at "Gene"
DOI: 10.1016/j.gene.2021.146032
Abstract: Gap junction (GJ), a special intercellular junction between different cell types, directly connects the cytoplasm of adjacent cells, allows various molecules, ions and electrical impulses to pass through the intercellular regulatory gate, and plays vital… read more here.
Keywords: scophthalmus maximus; gap junction; infection; turbot scophthalmus ... See more keywords
Mutation-targeted siRNA therapy for connexin 26-associated keratitis-ichthyosis-deafness syndrome
Sign Up to like & getrecommendations! Published in 2019 at "Cytotherapy"
DOI: 10.1016/j.jcyt.2019.04.033
Abstract: Background & Aim Keratitis-ichthyosis-deafness (KID) syndrome is a severe, currently untreatable condition characterized by ocular, auditory and cutaneous abnormalities, with major complications from infection to skin cancer. 86% of cases are caused by a heterozygous… read more here.
Keywords: gap junction; ichthyosis deafness; kid syndrome; keratitis ichthyosis ... See more keywords
Serotonergic transmission and gap junctional coupling in proventricular muscle cells in the American cockroach, Periplaneta americana.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of insect physiology"
DOI: 10.1016/j.jinsphys.2017.04.006
Abstract: The visceral muscle tissues of insects consist of striated muscle cells. The mechanisms responsible for delivering signals to the contractile muscles in the insect digestive tract remain unclear. We found that serotonergic nerves innervate the… read more here.
Keywords: muscle cells; muscle; gap junction; american cockroach ... See more keywords
Ginsenoside Re prevents angiotensin II‐induced gap‐junction remodeling by activation of PPAR&ggr; in isolated beating rat atria
Sign Up to like & getrecommendations! Published in 2017 at "Life Sciences"
DOI: 10.1016/j.lfs.2017.09.027
Abstract: Aims: Ginsenoside Re (G‐Re), a major ginsenoside in ginseng, has many beneficial pharmacological effects on negative cardiac contractility, electromechanical alternans, antiarrhythmia, angiogenic regeneration and cardiac electrophysiological function. However, effects of G‐Re on gap‐junction remodeling are… read more here.
Keywords: junction remodeling; gap junction; beating rat; ppar ggr ... See more keywords
NMDAR-mediated modulation of gap junction circuit regulates olfactory learning in C. elegans
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DOI: 10.1038/s41467-020-17218-0
Abstract: Modulation of gap junction-mediated electrical synapses is a common form of neural plasticity. However, the behavioral consequence of the modulation and the underlying molecular cellular mechanisms are not understood. Here, using a C. elegans circuit… read more here.
Keywords: gap; modulation; gap junctions; gap junction ... See more keywords
Loss of Gap Junction Delta-2 (GJD2) gene orthologs leads to refractive error in zebrafish
Sign Up to like & getrecommendations! Published in 2021 at "Communications Biology"
DOI: 10.1038/s42003-021-02185-z
Abstract: Myopia is the most common developmental disorder of juvenile eyes, and it has become an increasing cause of severe visual impairment. The GJD2 locus has been consistently associated with myopia in multiple independent genome-wide association… read more here.
Keywords: gap junction; refractive error; gjd2; role ... See more keywords