Pol V-Mediated Translesion Synthesis Elicits Localized Untargeted Mutagenesis during Post-replicative Gap Repair.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.06.120
Abstract: In vivo, replication forks proceed beyond replication-blocking lesions by way of downstream repriming, generating daughter strand gaps that are subsequently processed by post-replicative repair pathways such as homologous recombination and translesion synthesis (TLS). The way these… read more here.
Keywords: gap; post replicative; gap repair; pol ... See more keywords
Chronological Switch from Translesion Synthesis to Homology-Dependent Gap Repair In Vivo
Sign Up to like & getrecommendations! Published in 2018 at "Toxicological Research"
DOI: 10.5487/tr.2018.34.4.297
Abstract: Cells are constantly exposed to endogenous and exogenous chemical and physical agents that damage their genome by forming DNA lesions. These lesions interfere with the normal functions of DNA such as transcription and replication, and… read more here.
Keywords: dependent gap; translesion synthesis; gap repair; homology dependent ... See more keywords