LAUSR

About LAUSR
Donate
Contact Us

Follow us:

You are not signed in:

Sign Up!


   Articles with "gap43" as a keyword



Cryptic Splicing of GAP43 mRNA is a Novel Hallmark of TDP‐43‐Associated ALS and AD

Sign Up to like & get
recommendations! Published in 2025 at "Advanced Science"

DOI: 10.1002/advs.202412054

Abstract: Cytoplasmic aggregation of transactive response DNA‐binding protein 43 (TDP‐43) is a hallmark of amyotrophic lateral sclerosis (ALS) and occurs in 57% of Alzheimer's disease (AD) cases. TDP‐43 regulates RNA processing, including cryptic exon splicing. Here,… read more here.

Keywords: cryptic splicing; gap43; hallmark tdp; cryptic exon ... See more keywords
Photo from wikipedia

Resequencing and association analysis of GAP43 with autism spectrum disorder and schizophrenia in a Japanese population

Sign Up to like & get
recommendations! Published in 2021 at "Research in Autism Spectrum Disorders"

DOI: 10.1016/j.rasd.2021.101729

Abstract: Abstract Background Growth-associated protein 43 (GAP43), a synaptic protein involved in axonal growth and synaptic plasticity, is implicated in the pathophysiology of autism spectrum disorder (ASD) and schizophrenia. To examine the role of rare GAP43… read more here.

Keywords: japanese population; association analysis; autism spectrum; gap43 ... See more keywords

An unstable variant of GAP43 leads to neurodevelopmental deficiency

Sign Up to like & get
recommendations! Published in 2024 at "Scientific Reports"

DOI: 10.1038/s41598-024-83445-w

Abstract: Growth-associated protein 43 (GAP43) is a membrane-associated phosphoprotein predominantly expressed in the nervous systems, and controls axonal growth, branching, and pathfinding. While the association between GAP43 and human neurological disorders have been reported, the underlying… read more here.

Keywords: variant gap43; neurodevelopmental deficiency; gap43; gap43 leads ... See more keywords

Axonal localization of neuritin/CPG15 mRNA is limited by competition for HuD binding

Sign Up to like & get
recommendations! Published in 2017 at "Journal of Cell Science"

DOI: 10.1242/jcs.201244

Abstract: ABSTRACT HuD protein (also known as ELAVL4) has been shown to stabilize mRNAs with AU-rich elements (ARE) in their 3′ untranslated regions (UTRs), including Gap43, which has been linked to axon growth. HuD also binds… read more here.

Keywords: hud; nrn1 utr; axonal localization; localization ... See more keywords

lncRNA LOC100911717-targeting GAP43-mediated sympathetic remodeling after myocardial infarction in rats

Sign Up to like & get
recommendations! Published in 2023 at "Frontiers in Cardiovascular Medicine"

DOI: 10.3389/fcvm.2022.1019435

Abstract: Objective Sympathetic remodeling after myocardial infarction (MI) is the primary cause of ventricular arrhythmias (VAs), leading to sudden cardiac death (SCD). M1-type macrophages are closely associated with inflammation and sympathetic remodeling after MI. Long noncoding… read more here.

Keywords: lncrna loc100911717; loc100911717; myocardial infarction; gap43 ... See more keywords