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   Articles with "gapdh" as a keyword



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Physiology, phylogeny, early evolution, and GAPDH

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recommendations! Published in 2017 at "Protoplasma"

DOI: 10.1007/s00709-017-1095-y

Abstract: The chloroplast and cytosol of plant cells harbor a number of parallel biochemical reactions germane to the Calvin cycle and glycolysis, respectively. These reactions are catalyzed by nuclear encoded, compartment-specific isoenzymes that differ in their… read more here.

Keywords: physiology phylogeny; gapdh; early evolution; physiology ... See more keywords

Molecular and biochemical characterisation and recognition by the immune host of the glyceraldehyde 3-phosphate dehydrogenase (GAPDH) of the abomasal nematode parasite Teladorsagia circumcincta.

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recommendations! Published in 2017 at "Experimental parasitology"

DOI: 10.1016/j.exppara.2017.07.006

Abstract: A 1023 bp full length cDNA encoding Teladorsagia circumcincta GAPDH (TeciGAPDH) was cloned, expressed in Escherichia coli and the recombinant protein purified and its kinetic properties determined. A phylogenetic tree was constructed using helminth GAPDH… read more here.

Keywords: glyceraldehyde phosphate; gapdh; teladorsagia circumcincta;

Evaluation of the protective efficacy of four newly identified surface proteins of Erysipelothrix rhusiopathiae.

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recommendations! Published in 2018 at "Vaccine"

DOI: 10.1016/j.vaccine.2018.10.071

Abstract: Erysipelothrix rhusiopathiae is the causative agent of animal erysipelas and human erysipeloid. Bacterial surface proteins are promising vaccine candidates. We recently identified 3 E. rhusiopathiae surface proteins (GAPDH, HP0728, and HP1472) and characterized their roles… read more here.

Keywords: surface proteins; surface; gapdh; identified surface ... See more keywords

Dimethyl fumarate: targeting glycolysis to treat MS

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recommendations! Published in 2018 at "Cell Research"

DOI: 10.1038/s41422-018-0045-3

Abstract: Dimethyl fumarate (DMF) is an immunomodulatory drug used in patients with multiple sclerosis (MS) and psoriasis. Kornberg and colleagues shed new light on DMF activity, demonstrating that it blocks immune cell activation through inhibition of… read more here.

Keywords: glycolysis; gapdh; fumarate; dmf ... See more keywords

Macromolecular crowding and bicarbonate enhance the hydrogen peroxide-induced inactivation of glyceraldehyde-3-phosphate dehydrogenase

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recommendations! Published in 2024 at "Biochemical Journal"

DOI: 10.1042/bcj20240597

Abstract: The active site Cys residue in glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is sensitive to oxidation by hydrogen peroxide (H2O2), with this resulting in enzyme inactivation. This re-routes the carbon flux from glycolysis to the pentose phosphate pathway… read more here.

Keywords: bicarbonate; gapdh; glyceraldehyde phosphate; inactivation ... See more keywords

Structural basis of light-induced redox regulation in the Calvin–Benson cycle in cyanobacteria

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recommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.1906722116

Abstract: Significance The Calvin–Benson (CB) cycle in plants, algae, and cyanobacteria fixes most of the carbon in most of the biomass on Earth. The CB cycle is regulated by the redox state, which enables it to… read more here.

Keywords: cycle; gapdh; calvin benson; benson cycle ... See more keywords

Carbon dioxide/bicarbonate is required for sensitive inactivation of mammalian glyceraldehyde-3-phosphate dehydrogenase by hydrogen peroxide.

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recommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2221047120

Abstract: Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) contains an active site Cys and is one of the most sensitive cellular enzymes to oxidative inactivation and redox regulation. Here, we show that inactivation by hydrogen peroxide is strongly enhanced in… read more here.

Keywords: gapdh; bicarbonate; phosphate dehydrogenase; glyceraldehyde phosphate ... See more keywords

Monoclonal antibodies against recombinant GAPDH of Edwardsiella tarda reveal the conserved nature of the protein

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recommendations! Published in 2017 at "Food and Agricultural Immunology"

DOI: 10.1080/09540105.2017.1309642

Abstract: ABSTRACT The outer membrane protein, encoded by glyceraldehyde-3-phosphate dehydrogenase (GAPDH) gene, of Edwardsiella tarda is a highly conserved immunogenic protein. The GAPDH was cloned and expressed in Escherichia coli. The purified protein was used to… read more here.

Keywords: monoclonal antibodies; edwardsiella tarda; gapdh; mabs 3g12 ... See more keywords

RNA binding of GAPDH controls transcript stability and protein translation in acute myeloid leukemia

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recommendations! Published in 2025 at "RNA Biology"

DOI: 10.1080/15476286.2025.2580180

Abstract: ABSTRACT Dysregulation of RNA binding proteins (RBPs) is a hallmark in cancerous cells. In acute myeloid leukaemia (AML) RBPs are key regulators of tumour proliferation. While classical RBPs have defined RNA binding domains, RNA recognition… read more here.

Keywords: gapdh; acute myeloid; aml; translation ... See more keywords

Hydrogen sulfide-induced GAPDH sulfhydration disrupts the CCAR2-SIRT1 interaction to initiate autophagy.

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recommendations! Published in 2021 at "Autophagy"

DOI: 10.1080/15548627.2021.1876342

Abstract: The deacetylase SIRT1 (sirtuin 1) has emerged as a major regulator of nucleocytoplasmic distribution of macroautophagy/autophagy marker MAP1LC3/LC3 (microtubule-associated protein 1 light chain 3). Activation of SIRT1 leads to the deacetylation of LC3 and its… read more here.

Keywords: gapdh; autophagy; hydrogen sulfide; ccar2 sirt1 ... See more keywords

Nitrosylation of GAPDH augments pathological tau acetylation upon exposure to amyloid-β

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recommendations! Published in 2018 at "Science Signaling"

DOI: 10.1126/scisignal.aao6765

Abstract: Blocking the nitrosylation of GAPDH may reduce amyloid-induced tau toxicity in the brain and slow the progression of Alzheimer’s disease. Nitrosylation links amyloid and tau pathology Amyloid-β (Aβ), tau aggregates, and nitrosative stress all contribute… read more here.

Keywords: nitrosylation; tau acetylation; gapdh; pathology ... See more keywords