Physiology, phylogeny, early evolution, and GAPDH
Sign Up to like & getrecommendations! Published in 2017 at "Protoplasma"
DOI: 10.1007/s00709-017-1095-y
Abstract: The chloroplast and cytosol of plant cells harbor a number of parallel biochemical reactions germane to the Calvin cycle and glycolysis, respectively. These reactions are catalyzed by nuclear encoded, compartment-specific isoenzymes that differ in their… read more here.
Keywords: physiology phylogeny; gapdh; early evolution; physiology ... See more keywords
Molecular and biochemical characterisation and recognition by the immune host of the glyceraldehyde 3-phosphate dehydrogenase (GAPDH) of the abomasal nematode parasite Teladorsagia circumcincta.
Sign Up to like & getrecommendations! Published in 2017 at "Experimental parasitology"
DOI: 10.1016/j.exppara.2017.07.006
Abstract: A 1023 bp full length cDNA encoding Teladorsagia circumcincta GAPDH (TeciGAPDH) was cloned, expressed in Escherichia coli and the recombinant protein purified and its kinetic properties determined. A phylogenetic tree was constructed using helminth GAPDH… read more here.
Keywords: glyceraldehyde phosphate; gapdh; teladorsagia circumcincta;
Evaluation of the protective efficacy of four newly identified surface proteins of Erysipelothrix rhusiopathiae.
Sign Up to like & getrecommendations! Published in 2018 at "Vaccine"
DOI: 10.1016/j.vaccine.2018.10.071
Abstract: Erysipelothrix rhusiopathiae is the causative agent of animal erysipelas and human erysipeloid. Bacterial surface proteins are promising vaccine candidates. We recently identified 3 E. rhusiopathiae surface proteins (GAPDH, HP0728, and HP1472) and characterized their roles… read more here.
Keywords: surface proteins; surface; gapdh; identified surface ... See more keywords
Dimethyl fumarate: targeting glycolysis to treat MS
Sign Up to like & getrecommendations! Published in 2018 at "Cell Research"
DOI: 10.1038/s41422-018-0045-3
Abstract: Dimethyl fumarate (DMF) is an immunomodulatory drug used in patients with multiple sclerosis (MS) and psoriasis. Kornberg and colleagues shed new light on DMF activity, demonstrating that it blocks immune cell activation through inhibition of… read more here.
Keywords: glycolysis; gapdh; fumarate; dmf ... See more keywords
Structural basis of light-induced redox regulation in the Calvin–Benson cycle in cyanobacteria
Sign Up to like & getrecommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1906722116
Abstract: Significance The Calvin–Benson (CB) cycle in plants, algae, and cyanobacteria fixes most of the carbon in most of the biomass on Earth. The CB cycle is regulated by the redox state, which enables it to… read more here.
Keywords: cycle; gapdh; calvin benson; benson cycle ... See more keywords
Carbon dioxide/bicarbonate is required for sensitive inactivation of mammalian glyceraldehyde-3-phosphate dehydrogenase by hydrogen peroxide.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2221047120
Abstract: Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) contains an active site Cys and is one of the most sensitive cellular enzymes to oxidative inactivation and redox regulation. Here, we show that inactivation by hydrogen peroxide is strongly enhanced in… read more here.
Keywords: gapdh; bicarbonate; phosphate dehydrogenase; glyceraldehyde phosphate ... See more keywords
Monoclonal antibodies against recombinant GAPDH of Edwardsiella tarda reveal the conserved nature of the protein
Sign Up to like & getrecommendations! Published in 2017 at "Food and Agricultural Immunology"
DOI: 10.1080/09540105.2017.1309642
Abstract: ABSTRACT The outer membrane protein, encoded by glyceraldehyde-3-phosphate dehydrogenase (GAPDH) gene, of Edwardsiella tarda is a highly conserved immunogenic protein. The GAPDH was cloned and expressed in Escherichia coli. The purified protein was used to… read more here.
Keywords: monoclonal antibodies; edwardsiella tarda; gapdh; mabs 3g12 ... See more keywords
Hydrogen sulfide-induced GAPDH sulfhydration disrupts the CCAR2-SIRT1 interaction to initiate autophagy.
Sign Up to like & getrecommendations! Published in 2021 at "Autophagy"
DOI: 10.1080/15548627.2021.1876342
Abstract: The deacetylase SIRT1 (sirtuin 1) has emerged as a major regulator of nucleocytoplasmic distribution of macroautophagy/autophagy marker MAP1LC3/LC3 (microtubule-associated protein 1 light chain 3). Activation of SIRT1 leads to the deacetylation of LC3 and its… read more here.
Keywords: gapdh; autophagy; hydrogen sulfide; ccar2 sirt1 ... See more keywords
Nitrosylation of GAPDH augments pathological tau acetylation upon exposure to amyloid-β
Sign Up to like & getrecommendations! Published in 2018 at "Science Signaling"
DOI: 10.1126/scisignal.aao6765
Abstract: Blocking the nitrosylation of GAPDH may reduce amyloid-induced tau toxicity in the brain and slow the progression of Alzheimer’s disease. Nitrosylation links amyloid and tau pathology Amyloid-β (Aβ), tau aggregates, and nitrosative stress all contribute… read more here.
Keywords: nitrosylation; tau acetylation; gapdh; pathology ... See more keywords
Hijacking of Host Plasminogen by Mesomycoplasma (Mycoplasma) hyopneumoniae via GAPDH: an Important Virulence Mechanism To Promote Adhesion and Extracellular Matrix Degradation
Sign Up to like & getrecommendations! Published in 2023 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.00218-23
Abstract: Mesomycoplasma hyopneumoniae is a specific pathogen of pigs that is the etiological agent of mycoplasmal pneumonia of swine (MPS), which is responsible for substantial economic losses to the swine industry worldwide. The pathogenicity mechanism and… read more here.
Keywords: gapdh; mesomycoplasma; plasminogen; virulence ... See more keywords
Abstract 5496: A predictive model for selective targeting of the Warburg effect through GAPDH inhibition with a natural product
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-5496
Abstract: Cancer cells undergo numerous adaptive processes to sustain growth and survival. One notable mechanism is by rewiring metabolism, most prominently through a phenomenon known as the Warburg effect (WE). The WE is defined by increased… read more here.
Keywords: gapdh; inhibition; warburg effect; natural product ... See more keywords