A short isoform of spermatogenic enzyme GAPDHS functions as a metabolic switch and limits metastasis in melanoma.
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DOI: 10.1158/0008-5472.can-21-2062
Abstract: Despite being the leading cause of cancer deaths, metastasis remains a poorly understood process. To identify novel regulators of metastasis in melanoma, we performed a large-scale RNA-sequencing screen of 48 samples from patient-derived xenograft (PDX)… read more here.
Keywords: short isoform; metastasis; metabolic switch; melanoma ... See more keywords