Evaluation of Gene Expression Knock‐Down by Chemically and Structurally Modified Gapmer Antisense Oligonucleotides
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DOI: 10.1002/cbic.202200168
Abstract: We analyzed the effect of modified nucleotides within gapmer antisense oligonucleotides on RNase H mediated gene silencing. Additionally, short hairpins were introduced into antisense oligonucleotides as structural motifs, and their influence on biological and physicochemical… read more here.
Keywords: knock; antisense oligonucleotides; gene; gapmer antisense ... See more keywords