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Published in 2020 at "Chembiochem"
DOI: 10.1002/cbic.202000450
Abstract: Oligonucleotides (ON) are promising therapeutic candidates, for instance by blocking endogenous mRNA (antisense mechanism). However, ON usually require structural modifications of the native nucleic acid backbone to ensure satisfying pharmacokinetic properties. One such strategy to…
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Keywords:
naa lna;
partially zwitterionic;
gapmer approach;
lna gapmer ... See more keywords