Garcinol from Garcinia indica inhibits HIV‐1 reverse transcriptase‐associated ribonuclease H
Sign Up to like & getrecommendations! Published in 2021 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202100123
Abstract: The bioactive components of Garcinia indica, garcinol (camboginol), and isogarcinol (cambogin), are suitable drug candidates for the treatment of various human diseases. HIV‐1‐RNase H assay was used to study the RNase H inhibition by garcinol… read more here.
Keywords: garcinol; garcinia indica; reverse transcriptase; hiv reverse ... See more keywords
Binding mechanism of anacardic acid, carnosol and garcinol with PCAF: A comprehensive study using molecular docking and molecular dynamics simulations and binding free energy analysis
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.30400
Abstract: The p300/CBP associated factor bromodomain (PCAF Brd) is emerged as one of the promising target proteins for different types of cancers. PCAF is one among the histone acetyltransferase enzymes which involved in the regulation of… read more here.
Keywords: garcinol; acid carnosol; energy; anacardic acid ... See more keywords
Garcinol protects SH‐SY5Y cells against MPP+‐induced cell death by activating DJ‐1/SIRT1 and PGC‐1α mediated antioxidant pathway in sequential stimulation of p‐AMPK mediated autophagy
Sign Up to like & getrecommendations! Published in 2023 at "Environmental Toxicology"
DOI: 10.1002/tox.23737
Abstract: Parkinson's disease (PD), a chronic and progressive neurodegenerative disease, can reduce the population of dopaminergic neurons in the substantia nigra. The cause of this neuronal death remains unclear. 1‐Methyl‐4‐phenylpyridinium ion (MPP+) is a potent neurotoxin… read more here.
Keywords: cell death; sy5y cells; garcinol; death ... See more keywords
Garcinol blocks motor behavioural deficits by providing dopaminergic neuroprotection in MPTP mouse model of Parkinson's disease: involvement of anti-inflammatory response.
Sign Up to like & getrecommendations! Published in 2021 at "Experimental brain research"
DOI: 10.1007/s00221-021-06237-y
Abstract: Although the etiology of Parkinson's disease (PD) is poorly understood, studies in animal models revealed loss of dopamine and the dopaminergic neurons harbouring the neurotransmitter to be the principal cause behind this neuro-motor disorder. Neuroinflammation… read more here.
Keywords: anti inflammatory; garcinol; behavioural deficits; dopaminergic neuroprotection ... See more keywords
Garcinol-loaded novel cationic nanoliposomes: in vitro and in vivo study against B16F10 melanoma tumor model.
Sign Up to like & getrecommendations! Published in 2019 at "Nanomedicine"
DOI: 10.2217/nnm-2019-0022
Abstract: Aim: Garcinol (GAR)-loaded cationic nanoliposomes were developed to achieve potential antitumor efficacy on B16F10 melanoma cells in vitro and in vivo. Materials & methods: Two different phospholipids namely, distearoyl phosphatidylcholine (DSPC) and dipalmitoyl phosphatidylcholine (DPPC)… read more here.
Keywords: garcinol; vitro vivo; cationic nanoliposomes; gar ... See more keywords
Anti-Inflammatory Effect of Garcinol Extracted from Garcinia dulcis via Modulating NF-κB Signaling Pathway
Sign Up to like & getrecommendations! Published in 2023 at "Nutrients"
DOI: 10.3390/nu15030575
Abstract: Garcinia is a significant medicinal plant with many beneficial phytoconstituents, including garcinol. This study investigated the anti-inflammatory effect of garcinol isolated from Garcinia dulcis fruit in LPS-activated THP-1 and Raw 264.7 macrophages. The results demonstrated… read more here.
Keywords: garcinol; signaling pathway; garcinia dulcis; anti inflammatory ... See more keywords