Structural basis of latent TGF-β1 presentation and activation by GARP on human regulatory T cells
Sign Up to like & getrecommendations! Published in 2018 at "Science"
DOI: 10.1126/science.aau2909
Abstract: Visualizing TGF-β1 regulation by GARP Regulatory T cells (Tregs) can suppress immune responses through a variety of mechanisms. One such mechanism involves the activation of a surface-bound latent form of the cytokine transforming growth factor–β1… read more here.
Keywords: latent tgf; garp; antibody; regulatory cells ... See more keywords
Abstract 5198: Humanized mice for preclinical efficacy evaluation of drugs targeting GARP
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-5198
Abstract: Introduction: GARP (Glycoprotein-A repetitions predominant) is a cell surface receptor which is coded by Lrrc32 (Leucine rich repeat containing protein 32) and involved in the activation of TGF-beta. The expression of GARP has been widely… read more here.
Keywords: hgarp; treg; c57bl hgarp; garp ... See more keywords
Therapeutic activity of GARP:TGF-β1 blockade in murine primary myelofibrosis.
Sign Up to like & getrecommendations! Published in 2022 at "Blood"
DOI: 10.1182/blood.2022017097
Abstract: Primary myelofibrosis (PMF) is a myeloproliferative neoplasm characterized by clonal expansion of myeloid cells, notably megakaryocytes (MKs), and aberrant cytokine production leading to bone marrow (BM) fibrosis and insufficiency. Current treatment options are limited. TGF-b1,… read more here.
Keywords: cell; tgf blockade; garp; garp tgf ... See more keywords
GARP Polymorphisms Associated with Susceptibility to House Dust Mite-Sensitized Persistent Allergic Rhinitis in a Chinese Population
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Asthma and Allergy"
DOI: 10.2147/jaa.s366815
Abstract: Background Genetic variants in GARP (also known as LRRC32) have been reported to have significant associations with asthma and eczema in special populations, but little is known about allergic rhinitis. This study purposes to evaluate… read more here.
Keywords: hdm sensitized; garp; sensitized per; risk ... See more keywords
GARP dysfunction results in COPI displacement, depletion of Golgi v-SNAREs and calcium homeostasis proteins
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.1066504
Abstract: Golgi-associated retrograde protein (GARP) is an evolutionary conserved heterotetrameric protein complex that tethers endosome-derived vesicles and is vital for Golgi glycosylation. Microscopy and proteomic approaches were employed to investigate defects in Golgi physiology in RPE1… read more here.
Keywords: depletion golgi; garp; golgi snares; physiology ... See more keywords
Platelet-Derived GARP Induces Peripheral Regulatory T Cells—Potential Impact on T Cell Suppression in Patients with Melanoma-Associated Thrombocytosis
Sign Up to like & getrecommendations! Published in 2020 at "Cancers"
DOI: 10.3390/cancers12123653
Abstract: Simple Summary Thrombocytosis correlates with poor prognosis for treatment of malignant melanoma. Detailed information on how platelets modify the anti-tumoral immune response is still elusive. Analyzing the immunomodulatory capacities of platelets on huCD4+ T cells… read more here.
Keywords: thrombocytosis; garp; regulatory cells; melanoma patients ... See more keywords
Role of GARP Vesicle Tethering Complex in Golgi Physiology
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24076069
Abstract: The Golgi associated retrograde protein complex (GARP) is an evolutionarily conserved component of Golgi membrane trafficking machinery that belongs to the Complexes Associated with Tethering Containing Helical Rods (CATCHR) family. Like other multisubunit tethering complexes… read more here.
Keywords: garp; garp vesicle; physiology; golgi physiology ... See more keywords