LncRNA GAS5 positively regulates IL‐10 expression in patients with generalized myasthenia gravis
Sign Up to like & getrecommendations! Published in 2021 at "Brain and Behavior"
DOI: 10.1002/brb3.2457
Abstract: LncRNA growth arrest‐specific transcript 5 (GAS5) has been proven to be involved in autoimmune diseases. Rheumatoid arthritis is a type of autoimmune disease that may affect myasthenia gravis (MG) patients. However, its direct role in… read more here.
Keywords: myasthenia gravis; lncrna gas5; gas5; positively regulates ... See more keywords
Evaluation of prognostic usefulness of long noncoding RNA GAS5 and FAL1 in papillary thyroid carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28425
Abstract: Genetic studies on cancers have revealed that lncRNA‐GAS5 and lncRNA‐FAL1 are overexpressed in some cancerous cells. The aim of the present investigation was to evaluate the roles of lncRNA‐GAS5 and lncRNA‐FAL1 gene expression changes in… read more here.
Keywords: lncrna fal1; gas5; fal1; gas5 lncrna ... See more keywords
Relation of circulating lncRNA GAS5 and miR‐21 with biochemical indexes, stenosis severity, and inflammatory cytokines in coronary heart disease patients
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24202
Abstract: Long noncoding RNA GAS5 (lnc‐GAS5) and its target microRNA‐21 (miR‐21) regulate blood lipid, macrophages, Th cells, vascular smooth muscle cells to participate in atherosclerosis, and related coronary heart disease (CHD). The study aimed to further… read more here.
Keywords: biochemical indexes; coronary heart; gas5; stenosis severity ... See more keywords
Upregulation of lncRNA GAS5 inhibits the growth and metastasis of cervical cancer cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28926
Abstract: This study aims to figure out the methylation of long non‐coding RNA GAS5 promoter in cervical cancer and the mechanism of GAS5 on the progression of cervical cancer cells. The expression of GAS5 and methylation… read more here.
Keywords: cancer cells; cervical cancer; growth metastasis; gas5 ... See more keywords
LncRNA GAS5 upregulates Smad4 to suppress the apoptosis of chondrocytes induced by lipopolysaccharide.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of gerontology and geriatrics"
DOI: 10.1016/j.archger.2021.104478
Abstract: BACKGROUND Osteoarthritis (OA) is closely correlated with inflammation. It has been reported that lncRNA GAS5 plays an important role in inflammation, indicating the potential involvement of GAS5 in OA. This study was carried out to… read more here.
Keywords: overexpression; mir 146a; apoptosis; gas5 ... See more keywords
A Genetic Variant of rs145204276 in the Promoter Region of Long Noncoding RNA GAS5 Is Associated With a Reduced Risk of Breast Cancer.
Sign Up to like & getrecommendations! Published in 2018 at "Clinical breast cancer"
DOI: 10.1016/j.clbc.2018.11.006
Abstract: INTRODUCTION Growth arrest-specific 5 (GAS5), downregulated in breast cancer (BC), functions as a tumor suppressor by affecting tumor growth and cell apoptosis in vivo and in vitro. This study was designed to determine whether an insertion (ins)/deletion… read more here.
Keywords: gas5; breast cancer; rs145204276; promoter ... See more keywords
Down-regulation of lncRNA Gas5 promotes hypoxia-induced pulmonary arterial smooth muscle cell proliferation by regulating KCNK3 expression.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173618
Abstract: Pulmonary hypertension (PH) is a progressive and potentially serious lung disease, defined by an abnormal elevation of pulmonary arterial pressure. PH occurs for many reasons, and hypoxia is considered as an important stimulus for the… read more here.
Keywords: proliferation migration; gas5; proliferation; expression ... See more keywords
LncRNA GAS5 participates in the regulation of dexamethasone on androgen receptor -negative and -positive prostate cancer cell proliferation.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular and cellular probes"
DOI: 10.1016/j.mcp.2020.101607
Abstract: BACKGROUND Androgen receptor (AR) and long non-coding RNAs (lncRNA) play important roles in the initiation and progression of prostate cancer (PCa). The present study was designed to investigate whether lncRNA growth arrest-specific 5 (GAS5) is… read more here.
Keywords: gas5; cell proliferation; proliferation; regulation dexamethasone ... See more keywords
Long noncoding RNA-GAS5 retards renal fibrosis through repressing miR-21 activity.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental and molecular pathology"
DOI: 10.1016/j.yexmp.2020.104518
Abstract: BACKGROUND/AIMS Long noncoding RNA (lncRNA) is a large and diverse class of RNA molecules, and has received widespread attention for its role in the regulation of various biological processes, including stem cell transformation, neurological disease,… read more here.
Keywords: long noncoding; fibrosis; gas5; rna ... See more keywords
Low-expressed GAS5 injure myocardial cells and progression of chronic heart failure via regulation of miR-223-3P.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental and molecular pathology"
DOI: 10.1016/j.yexmp.2020.104529
Abstract: Chronic heart failure (CHF) is a common disease in clinical practice, and its incidence has been increasing in recent years. Understanding the pathogenesis of CHF is the key to its future clinical diagnosis and treatment.… read more here.
Keywords: gas5; heart failure; myocardial cells; chf ... See more keywords
Isosteviol Sodium Protects against Ischemic Stroke by Modulating Microglia/Macrophage Polarization via Disruption of GAS5/miR-146a-5p sponge
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-48759-0
Abstract: Recent studies have shown that transforming microglia phenotype from pro-inflammation of M1 phenotype to anti-inflammation and tissue-repairing M2 phenotype may be an effective therapeutic strategy for preventing ischemic stroke brain injury. Isosteviol Sodium (STV-Na) has… read more here.
Keywords: ischemic stroke; isosteviol sodium; mir 146a; gas5 ... See more keywords