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Published in 2017 at "Glia"
DOI: 10.1002/glia.23113
Abstract: Myelin is an essential component of the mammalian nervous system, facilitating rapid conduction of electrical impulses by axons, as well as providing trophic support to neurons. Within the central nervous system, the oligodendrocyte is the…
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Keywords:
gas6;
nervous system;
central nervous;
myelination ... See more keywords
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Published in 2019 at "Cellular and Molecular Gastroenterology and Hepatology"
DOI: 10.1016/j.jcmgh.2019.10.010
Abstract: Background and Aims GAS6 signaling, through the TAM receptor tyrosine kinases AXL and MERTK, participates in chronic liver pathologies. Here, we addressed GAS6/TAM involvement in Non-Alcoholic SteatoHepatitis (NASH) development. Methods GAS6/TAM signaling was analyzed in…
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Keywords:
gas6;
gas6 tam;
hfd fed;
fed mice ... See more keywords
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Published in 2020 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2020.11.013
Abstract: Published evidences have shown that autophagy plays an important role in silica-induced lung inflammation and collagen deposition. Our previous study found that the level of growth arrest-specific protein 6 (Gas6) in bronchoalveolar lavage fluid was…
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Keywords:
gas6;
autophagosomes accumulation;
mer;
silica induced ... See more keywords
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Published in 2022 at "Renal Failure"
DOI: 10.1080/0886022x.2022.2092001
Abstract: Abstract Acute kidney injury (AKI) is a common complication of sepsis and increase morbidity and mortality. Long non-coding RNA (LncRNA) GAS6-AS2 was related to inflammation and apoptosis in different diseases by regulating miRNAs and downstream…
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Keywords:
sepsis related;
kidney injury;
gas6 as2;
mir 136 ... See more keywords
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Published in 2020 at "Cell Cycle"
DOI: 10.1080/15384101.2020.1729323
Abstract: ABSTRACT Long non-coding RNA termed GAS6 antisense RNA 1 (GAS6-AS1) plays an essential role in gastric and non-small cell lung cancers. Nonetheless, the function of GAS6-AS1 in hepatocellular carcinoma (HCC) has not been so far…
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Keywords:
gas6;
hcc;
gas6 as1;
rna ... See more keywords
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Published in 2022 at "Molecular human reproduction"
DOI: 10.1093/molehr/gaac006
Abstract: Maternal immunotolerance toward the semi-allogeneic fetus is critical for normal pregnancy. As a secretory protein, growth arrest-specific factor 6 (GAS6) promotes cancer progression by inducing the conversion of tumour-associated macrophages to an immunosuppressive M2-like phenotype.…
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Keywords:
decidual macrophages;
cell proliferation;
pregnancy;
gas6 ... See more keywords
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Published in 2022 at "Disease Markers"
DOI: 10.1155/2022/1568352
Abstract: Reliable biomarkers allowing early patients' stratification for the risk of adverse outcomes in COVID-19 are lacking. Gas6, together with its tyrosine kinase receptors named TAM, is involved in the regulation of immune homeostasis, fibrosis, and…
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Keywords:
adverse outcomes;
protein elevation;
plasma gas6;
baseline plasma ... See more keywords
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Published in 2020 at "Blood"
DOI: 10.1182/blood-2020-136388
Abstract: Background: Pancreatic cancer (PC) remains one of the most difficult tumors to treat. PC is nearly always diagnosed late with 80% of PC patients having Stage 4 disease and an average life expectancy of a…
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Keywords:
gas6;
cell lines;
aggressiveness;
expression ... See more keywords
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Published in 2019 at "Blood advances"
DOI: 10.1182/bloodadvances.2019000222
Abstract: Endothelial dysfunction in the early phases of hematopoietic stem cell transplantation (HSCT) contributes to a common pathology between transplant-associated thrombotic microangiopathy (TA-TMA) and graft-versus-host disease (GVHD), which are serious complications of HSCT. Growth arrest-specific (Gas)…
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Keywords:
mer axis;
gas6;
gas6 mer;
mer ... See more keywords
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Published in 2022 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-022-02397-y
Abstract: Background Alzheimer’s disease is the leading cause of dementia worldwide. TAM receptor tyrosine kinases (Tyro3, Axl, MerTK) are known for their role in engagement of phagocytosis and modulation of inflammation, and recent evidence suggests a…
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Keywords:
app ps1;
disease;
pathology;
alzheimer disease ... See more keywords
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Published in 2020 at "OncoTargets and therapy"
DOI: 10.2147/ott.s237174
Abstract: Background Growth arrest-specific 6 (GAS6) is a secreted vitamin K-dependent protein abnormally expressed in various human tumor tissues and can activate the receptor Tyro3, Axl, and Mer to promote cancer cell proliferation and invasion. Until…
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Keywords:
proliferation invasion;
gas6;
cancer;
proliferation ... See more keywords