The Gasdermin‐D pore acts as a conduit for IL‐1β secretion in mice
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Immunology"
DOI: 10.1002/eji.201747404
Abstract: The pro‐inflammatory cytokine IL‐1β is well known for its role in host defense and the initiation of potent inflammatory responses. It is processed from its inactive pro‐form by the inflammatory caspase‐1 into its mature bioactive… read more here.
Keywords: secretion; gasdermin pore; pore acts; conduit secretion ... See more keywords
Gasdermin E mediates pyroptotic cell death of neutrophils and macrophages in a zebrafish model of chronic skin inflammation.
Sign Up to like & getrecommendations! Published in 2022 at "Developmental and comparative immunology"
DOI: 10.1016/j.dci.2022.104404
Abstract: Chronic disease and hematopoietic disorders are associated with dysregulation of the inflammasome. Our group has recently reported the relevance of the inflammasome in the differentiation of hematopoietic stem and progenitor cells. However, the impact of… read more here.
Keywords: gasdermin; zebrafish model; skin inflammation; death ... See more keywords
Crystal Structures of the Full-Length Murine and Human Gasdermin D Reveal Mechanisms of Autoinhibition, Lipid Binding, and Oligomerization.
Sign Up to like & getrecommendations! Published in 2019 at "Immunity"
DOI: 10.1016/j.immuni.2019.04.017
Abstract: Gasdermin D (GSDMD) is an effector molecule for pyroptosis downstream of canonical and noncanonical inflammasome signaling pathways. Cleavage of GSDMD by inflammatory caspases triggers the oligomerization and lipid binding by its N-terminal domain, which assembles membrane… read more here.
Keywords: murine; lipid binding; binding oligomerization; crystal structures ... See more keywords
Gasdermin D pores are dynamically regulated by local phosphoinositide circuitry
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-021-27692-9
Abstract: Gasdermin D forms large, ~21 nm diameter pores in the plasma membrane to drive the cell death program pyroptosis. These pores are thought to be permanently open, and the resultant osmotic imbalance is thought to be… read more here.
Keywords: gasdermin; pores dynamically; dynamically regulated; local phosphoinositide ... See more keywords
A bioorthogonal system reveals antitumour immune function of pyroptosis
Sign Up to like & getrecommendations! Published in 2020 at "Nature"
DOI: 10.1038/s41586-020-2079-1
Abstract: Bioorthogonal chemistry capable of operating in live animals is needed to investigate biological processes such as cell death and immunity. Recent studies have identified a gasdermin family of pore-forming proteins that executes inflammasome-dependent and -independent… read more here.
Keywords: system; pyroptosis; bioorthogonal system; gasdermin ... See more keywords
Human gasdermin D and MLKL disrupt mitochondria, endocytic traffic and TORC1 signalling in budding yeast
Sign Up to like & getrecommendations! Published in 2022 at "Open Biology"
DOI: 10.1098/rsob.220366
Abstract: Gasdermin D (GSDMD) and mixed lineage kinase domain-like protein (MLKL) are the pore-forming effectors of pyroptosis and necroptosis, respectively, with the capacity to disturb plasma membrane selective permeability and induce programmed cell death. The budding… read more here.
Keywords: gasdermin; gsdmd; torc1; mlkl ... See more keywords
NET formation is independent of gasdermin D and pyroptotic cell death
Sign Up to like & getrecommendations! Published in 2023 at "Science Signaling"
DOI: 10.1126/scisignal.abm0517
Abstract: Neutrophil extracellular traps (NETs) are DNA scaffolds coated with granule proteins that are released by neutrophils to ensnare and kill bacteria. NET formation occurs in response to many stimuli through independent molecular pathways. Although NET… read more here.
Keywords: formation; net formation; cell death; gasdermin ... See more keywords
An ancient defense mechanism: Conservation of gasdermin-mediated pyroptosis
Sign Up to like & getrecommendations! Published in 2023 at "PLOS Biology"
DOI: 10.1371/journal.pbio.3002103
Abstract: The gasdermins are a family of pore-forming proteins involved in various cellular processes such as cell death and inflammation. A new study in PLOS Biology explores the evolutionary history of gasdermins across metazoans, highlighting the… read more here.
Keywords: gasdermin; conservation; mechanism conservation; defense mechanism ... See more keywords
Sevoflurane Aggravates the Progress of Alzheimer’s Disease Through NLRP3/Caspase-1/Gasdermin D Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.801422
Abstract: Background: Alzheimer’s disease (AD) is the most common form of dementia worldwide. Previous studies have reported that sevoflurane, a frequently used anesthetic, can induce cognitive impairment in preclinical and clinical settings. However, the mechanism underlying… read more here.
Keywords: gasdermin; nlrp3 caspase; alzheimer disease; sevoflurane ... See more keywords
New insights into the evolutionary dynamic and lineage divergence of gasdermin E in metazoa
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.952015
Abstract: Gasdermin (GSDM) is a family of pore-forming proteins that induce pyroptosis. To date, the origin and evolution of GSDM in Metazoa remain elusive. Here, we found that GSDM emerged early in Placozoa but is absent… read more here.
Keywords: gasdermin; insights evolutionary; recognition motif; caspase recognition ... See more keywords
Porcine Gasdermin D Is a Substrate of Caspase-1 and an Executioner of Pyroptosis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.828911
Abstract: Gasdermin (GSDM) family proteins were recently identified as the executioner of pyroptosis. The mechanism of pyroptosis mediated by gasdermin D (GSDMD) (a member of GSDM family) in humans and mice is well understood. In pyroptosis,… read more here.
Keywords: gasdermin; gsdmd; pcaspase; pyroptosis ... See more keywords