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   Articles with "gasdermin" as a keyword



Fluoroalkane Engineered Magnetic Vectors Unlock the Potential of Gasdermin in Vivo Delivery for Pyroptosis Induced Cancer Therapy

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recommendations! Published in 2025 at "Advanced Healthcare Materials"

DOI: 10.1002/adhm.202500801

Abstract: Pyroptosis, a programmed necrotic cell death mediated by gasdermin, can activate strong immune responses and serve as a potential target for cancer therapy. Nevertheless, the relatively large molecular size and negative surface charge of gasdermin… read more here.

Keywords: delivery system; pyroptosis; gasdermin; delivery ... See more keywords

Caspase‐6/Gasdermin C‐Mediated Tumor Cell Pyroptosis Promotes Colorectal Cancer Progression Through CXCL2‐Dependent Recruitment of Myeloid‐Derived Suppressor Cells

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recommendations! Published in 2025 at "Advanced Science"

DOI: 10.1002/advs.202411375

Abstract: Gasdermin (GSDM) family proteins mediate inflammatory cell pyroptosis and exert critical contributions to the pathogenesis of gastrointestinal cancers, infections, and gut mucosal inflammation. Gasdermin C (GSDMC) is overexpressed in human colorectal cancer (CRC); however, the… read more here.

Keywords: cell pyroptosis; pyroptosis; gasdermin; crc ... See more keywords

The Gasdermin‐D pore acts as a conduit for IL‐1β secretion in mice

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recommendations! Published in 2018 at "European Journal of Immunology"

DOI: 10.1002/eji.201747404

Abstract: The pro‐inflammatory cytokine IL‐1β is well known for its role in host defense and the initiation of potent inflammatory responses. It is processed from its inactive pro‐form by the inflammatory caspase‐1 into its mature bioactive… read more here.

Keywords: secretion; gasdermin pore; pore acts; conduit secretion ... See more keywords

Gasdermin E mediates pyroptotic cell death of neutrophils and macrophages in a zebrafish model of chronic skin inflammation.

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recommendations! Published in 2022 at "Developmental and comparative immunology"

DOI: 10.1016/j.dci.2022.104404

Abstract: Chronic disease and hematopoietic disorders are associated with dysregulation of the inflammasome. Our group has recently reported the relevance of the inflammasome in the differentiation of hematopoietic stem and progenitor cells. However, the impact of… read more here.

Keywords: gasdermin; zebrafish model; skin inflammation; death ... See more keywords

Crystal Structures of the Full-Length Murine and Human Gasdermin D Reveal Mechanisms of Autoinhibition, Lipid Binding, and Oligomerization.

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recommendations! Published in 2019 at "Immunity"

DOI: 10.1016/j.immuni.2019.04.017

Abstract: Gasdermin D (GSDMD) is an effector molecule for pyroptosis downstream of canonical and noncanonical inflammasome signaling pathways. Cleavage of GSDMD by inflammatory caspases triggers the oligomerization and lipid binding by its N-terminal domain, which assembles membrane… read more here.

Keywords: murine; lipid binding; binding oligomerization; crystal structures ... See more keywords

Gasdermin D pores are dynamically regulated by local phosphoinositide circuitry

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recommendations! Published in 2022 at "Nature Communications"

DOI: 10.1038/s41467-021-27692-9

Abstract: Gasdermin D forms large, ~21 nm diameter pores in the plasma membrane to drive the cell death program pyroptosis. These pores are thought to be permanently open, and the resultant osmotic imbalance is thought to be… read more here.

Keywords: gasdermin; pores dynamically; dynamically regulated; local phosphoinositide ... See more keywords

A bioorthogonal system reveals antitumour immune function of pyroptosis

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recommendations! Published in 2020 at "Nature"

DOI: 10.1038/s41586-020-2079-1

Abstract: Bioorthogonal chemistry capable of operating in live animals is needed to investigate biological processes such as cell death and immunity. Recent studies have identified a gasdermin family of pore-forming proteins that executes inflammasome-dependent and -independent… read more here.

Keywords: system; pyroptosis; bioorthogonal system; gasdermin ... See more keywords

Human gasdermin D and MLKL disrupt mitochondria, endocytic traffic and TORC1 signalling in budding yeast

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recommendations! Published in 2022 at "Open Biology"

DOI: 10.1098/rsob.220366

Abstract: Gasdermin D (GSDMD) and mixed lineage kinase domain-like protein (MLKL) are the pore-forming effectors of pyroptosis and necroptosis, respectively, with the capacity to disturb plasma membrane selective permeability and induce programmed cell death. The budding… read more here.

Keywords: gasdermin; gsdmd; torc1; mlkl ... See more keywords

NET formation is independent of gasdermin D and pyroptotic cell death

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recommendations! Published in 2023 at "Science Signaling"

DOI: 10.1126/scisignal.abm0517

Abstract: Neutrophil extracellular traps (NETs) are DNA scaffolds coated with granule proteins that are released by neutrophils to ensnare and kill bacteria. NET formation occurs in response to many stimuli through independent molecular pathways. Although NET… read more here.

Keywords: formation; net formation; cell death; gasdermin ... See more keywords

An ancient defense mechanism: Conservation of gasdermin-mediated pyroptosis

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recommendations! Published in 2023 at "PLOS Biology"

DOI: 10.1371/journal.pbio.3002103

Abstract: The gasdermins are a family of pore-forming proteins involved in various cellular processes such as cell death and inflammation. A new study in PLOS Biology explores the evolutionary history of gasdermins across metazoans, highlighting the… read more here.

Keywords: gasdermin; conservation; mechanism conservation; defense mechanism ... See more keywords

Gasdermin D mutation protects against renal ischemia reperfusion injury

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recommendations! Published in 2025 at "Physiological Reports"

DOI: 10.14814/phy2.70254

Abstract: Pyroptosis, the most inflammatory form of cell death, is dependent on membrane pore formation governed by the assembly of cleaved Gasdermin D (GSDMD). We hypothesized that regulated necrosis pathways are crucial in the pathophysiology of… read more here.

Keywords: renal ischemia; ischemia reperfusion; gasdermin; reperfusion injury ... See more keywords