Extra- vs. Intracellular Delivery of CO: Does it Matter for a Stable, Diffusible Gasotransmitter?
Sign Up to like & getrecommendations! Published in 2019 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.9b01254
Abstract: Carbon monoxide (CO) is a gasotransmitter produced in humans. An essential unanswered question in the design of carbon monoxide releasing molecules (CORMs) is whether the delivery molecule should be localized extra- or intracellularly to produce… read more here.
Keywords: extra intracellular; gasotransmitter; delivery matter; delivery ... See more keywords
Updates on versatile role of putative gasotransmitter nitric oxide: culprit in neurodegenerative disease pathology.
Sign Up to like & getrecommendations! Published in 2020 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.0c00230
Abstract: Nitric oxide (NO) is a versatile gasotransmitter contribute in a range of physiological and pathological mechanims depending on its cellular levels. Appropriate concentration of NO is essentially required for the cellular physiology however its increased… read more here.
Keywords: neurodegenerative disease; gasotransmitter; pathology; physiology ... See more keywords
Recent Development of the Molecular and Cellular Mechanisms of Hydrogen Sulfide Gasotransmitter
Sign Up to like & getrecommendations! Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox11091788
Abstract: Hydrogen sulfide has been recently identified as the third biological gasotransmitter, along with the more well studied nitric oxide (NO) and carbon monoxide (CO). Intensive studies on its potential as a therapeutic agent for cardiovascular,… read more here.
Keywords: gasotransmitter; development molecular; hydrogen; molecular cellular ... See more keywords