Efficacy and Safety of Fenfluramine for the Treatment of Seizures Associated With Lennox-Gastaut Syndrome
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Neurology"
DOI: 10.1001/jamaneurol.2022.0829
Abstract: This randomized clinical trial examines the change from baseline in drop seizure frequency, response rates, and improvement on the Clinical Global Impression scale among patients with Lennox-Gastaut syndrome. read more here.
Keywords: lennox gastaut; safety fenfluramine; fenfluramine treatment; treatment seizures ... See more keywords
Lennox-Gastaut syndrome: a comprehensive review
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DOI: 10.1007/s10072-017-3188-y
Abstract: Lennox-Gastaut syndrome (LGS) is considered an epileptic encephalopathy and is defined by a triad of multiple drug-resistant seizure types, a specific EEG pattern showing bursts of slow spike-wave complexes or generalized paroxysmal fast activity, and… read more here.
Keywords: syndrome comprehensive; lennox gastaut; drug; gastaut syndrome ... See more keywords
Efficacy and Safety of Adjunctive Cannabidiol in Patients with Lennox–Gastaut Syndrome: A Systematic Review and Meta-Analysis
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DOI: 10.1007/s40263-018-0558-9
Abstract: AbstractBackgroundLennox–Gastaut syndrome (LGS) is a severe developmental epileptic encephalopathy, and available interventions fail to control seizures in most patients. Cannabidiol (CBD) is a major chemical of marijuana, which has anti-seizure properties and different mechanisms of… read more here.
Keywords: cbd; efficacy safety; seizure frequency; gastaut syndrome ... See more keywords
Rufinamide efficacy and safety in children aged 1–4 years with Lennox–Gastaut syndrome
Sign Up to like & getrecommendations! Published in 2018 at "Brain and Development"
DOI: 10.1016/j.braindev.2018.07.020
Abstract: PURPOSE The treatment options for Lennox-Gastaut syndrome (LGS), a pediatric epileptic syndrome, are limited, especially in younger children. Rufinamide tablets were safe and effective as an add-on treatment in Korean children and adolescents read more here.
Keywords: aged years; efficacy safety; rufinamide; treatment ... See more keywords
Electroclinical pattern in the transition from West to Lennox-Gastaut syndrome
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DOI: 10.1016/j.eplepsyres.2020.106446
Abstract: AIM The aim of this study was to analyze electroclinical features of a group of patients with West syndrome (WS) who subsequently developed Lennox-Gastaut syndrome (LGS) during the transition between both syndromes. METHODS A retrospective… read more here.
Keywords: electroclinical pattern; transition; lennox gastaut; group ... See more keywords
Efficacy and Tolerability of Lacosamide in Lennox–Gastaut Syndrome: A Systematic Review and Meta-analysis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neurosciences in Rural Practice"
DOI: 10.1055/s-0041-1740580
Abstract: Abstract Purpose Lennox–Gastaut syndrome (LGS) is one of the most difficult to treat childhood-onset epileptic encephalopathies. There is growing evidence that lacosamide is safe and efficacious in patients and adults with refractory epilepsy. However, the evidence… read more here.
Keywords: tolerability lacosamide; efficacy tolerability; review; efficacy ... See more keywords
An evaluation of clobazam tablets and film (AQST-120) for the treatment of Lennox-Gastaut syndrome
Sign Up to like & getrecommendations! Published in 2019 at "Expert Opinion on Pharmacotherapy"
DOI: 10.1080/14656566.2019.1642872
Abstract: ABSTRACT Introduction: Lennox-Gastaut syndrome (LGS) is a chronic, epileptic encephalopathy, characterized by multiple seizure types, distinctive slow spike-wave patterns in the electroencephalogram (EEG), and severe cognitive and behavioral comorbidities. Seizures are typically refractory and long-term… read more here.
Keywords: treatment; lennox gastaut; aqst 120; clb ... See more keywords
Current and emerging pharmacotherapy for the treatment of Lennox-Gastaut syndrome.
Sign Up to like & getrecommendations! Published in 2023 at "Expert opinion on pharmacotherapy"
DOI: 10.1080/14656566.2023.2215924
Abstract: INTRODUCTION Lennox-Gastaut syndrome (LGS) is a severe childhood-onset epileptic encephalopathy, characterised by multiple seizure types, generalised slow spike-and-wave complexes on the EEG, and cognitive impairment. Seizures in LGS are typically resistant to treatment with antiseizure… read more here.
Keywords: emerging pharmacotherapy; lennox gastaut; current emerging; treatment ... See more keywords
Novel therapeutic options for Dravet and Lennox-Gastaut syndrome
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DOI: 10.1080/14737175.2020.1862651
Abstract: Epileptic encephalopathies affect around one in 2000 children and often receive supportive treatment.Therefore, novel strategies to improve their overall neurological outcome are needed. Dravet syndrome (DS) is a genetic condition that is primarily associated with… read more here.
Keywords: therapeutic options; dravet lennox; lennox gastaut; options dravet ... See more keywords
A Novel X-Linked Variant of IQSEC2 is Associated with Lennox-Gastaut Syndrome and Mild Intellectual Disability in Three Generations of a Korean Family.
Sign Up to like & getrecommendations! Published in 2019 at "Genetic testing and molecular biomarkers"
DOI: 10.1089/gtmb.2019.0177
Abstract: Aim: Lennox-Gastaut syndrome (LGS) is a severe type of childhood-onset epilepsy with multiple types of seizures, specific discharges on electroencephalography, and intellectual disability. However, LGS-related genes are largely unknown. To identify causative genes related to… read more here.
Keywords: gastaut syndrome; intellectual disability; disability; lennox gastaut ... See more keywords
Adult motor phenotype differentiates Dravet syndrome from Lennox‐Gastaut syndrome and links SCN1A to early onset parkinsonian features
Sign Up to like & getrecommendations! Published in 2017 at "Epilepsia"
DOI: 10.1111/epi.13692
Abstract: Distinguishing adult patients with Lennox‐Gastaut syndrome from those with Dravet syndrome is challenging. We have previously reported that patients with Dravet syndrome present a very peculiar motor phenotype. Here we sought to confirm that this… read more here.
Keywords: adult; lennox gastaut; motor phenotype; dravet syndrome ... See more keywords