Current and future strategies for radiation therapy in gastric cancer
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Surgical Oncology"
DOI: 10.1002/jso.26880
Abstract: Gastric cancers are heterogeneous. There are important differences between gastric and junctional tumors and a focus on evidence based on true gastric cancers is important to guide treatment decision and the design of innovative strategies.… read more here.
Keywords: strategies radiation; future strategies; gastric cancers; therapy gastric ... See more keywords
Methylation silencing of ULK2 via epithelial–mesenchymal transition causes transformation to poorly differentiated gastric cancers
Sign Up to like & getrecommendations! Published in 2021 at "Gastric Cancer"
DOI: 10.1007/s10120-021-01250-0
Abstract: Diffuse-type gastric cancers (DGC) typically have a poor prognosis related to their invasion and metastasis, in which the epithelial–mesenchymal transition (EMT) is the initiation step. ULK2 plays a role in the autophagy initiation, which might… read more here.
Keywords: mesenchymal transition; gastric cancers; knock ulk2; epithelial mesenchymal ... See more keywords
rs6426881 in the 3'-UTR of PBX1 is involved in breast and gastric cancers via altering the binding potential of miR-522-3p.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular biology reports"
DOI: 10.1007/s11033-021-06756-5
Abstract: BACKGROUND Breast and gastric cancers are the most important diseases that lead to cancer death and social healthcare challenge. Overexpression of PBX1, a proto-oncogene, is correlated with the progression and metastasis of various cancers. For the… read more here.
Keywords: breast gastric; gastric cancers; pbx1; cancer ... See more keywords
PD-1 and PD-L1 inhibitors in oesophago-gastric cancers.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer letters"
DOI: 10.1016/j.canlet.2019.10.036
Abstract: Oesophago-gastric cancers (OGCs) are aggressive tumours. While better peri-operative strategies, increased number of cytotoxic agents and availability of targeted therapies have improved survival, there remains an unmet need for novel treatment approaches. Immune checkpoint inhibitors… read more here.
Keywords: inhibitors oesophago; ogc; gastric cancers; oesophago gastric ... See more keywords
Evolving therapies in advanced oesophago-gastric cancers and the increasing role of immunotherapy
Sign Up to like & getrecommendations! Published in 2020 at "Expert Review of Anticancer Therapy"
DOI: 10.1080/14737140.2021.1866548
Abstract: ABSTRACT Introduction Esophagogastric cancers remain a considerable health burden and among the top causes of global cancer-related deaths. Chemotherapy remains the cornerstone of treatment for patients with advanced disease. Doublet platinum/fluoropyrimidine therapy is established as… read more here.
Keywords: gastric cancers; oesophago gastric; treatment; therapies advanced ... See more keywords
Immunotherapy for gastric cancers: emerging role and future perspectives
Sign Up to like & getrecommendations! Published in 2017 at "Expert Review of Clinical Pharmacology"
DOI: 10.1080/17512433.2017.1313113
Abstract: ABSTRACT Introduction: The broad use of immunotherapy is revolutionizing the treatment paradigms of many solid tumors. Although chemotherapy remains the treatment backbone for advanced gastric cancer, improvements in its molecular characterization and progresses in understanding… read more here.
Keywords: role future; gastric cancers; emerging role; cancers emerging ... See more keywords
Polyamine synthesis enzyme AMD1 is closely associated with tumorigenesis and prognosis of human gastric cancers.
Sign Up to like & getrecommendations! Published in 2019 at "Carcinogenesis"
DOI: 10.1093/carcin/bgz098
Abstract: Adenosylmethionine decarboxylase 1 (AMD1) is a key enzyme involved in biosynthesis of polyamines includingspermidine and spermine. The potential function of AMD1 in human gastric cancers is unknown. We analyzed AMD1 expression level in 319 human… read more here.
Keywords: gastric cancers; expression; amd1; human gastric ... See more keywords
Epstein–Barr virus positivity among surgically resected intramucosal gastric cancer
Sign Up to like & getrecommendations! Published in 2018 at "Digestive Endoscopy"
DOI: 10.1111/den.13181
Abstract: Epstein–Barr virus‐associated gastric cancer (EBV‐GC) accounts for approximately 8% of gastric cancers. However, little is known regarding intramucosal EBV‐GC. The present study aimed to evaluate endoscopic and clinicopathological characteristics of intramucosal EBV‐GC. Pathological data of… read more here.
Keywords: epstein barr; gastric cancers; gastric cancer; barr virus ... See more keywords
Genomic pathobiology of gastric carcinoma
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DOI: 10.1111/pin.12493
Abstract: With the recent advances in genome sequencing technologies, comprehensive cancer genomic profiling has revealed the in‐depth molecular mechanisms of gastric malignancies. New insights into the carcinogenesis pathways of gastric cancers have been acquired, not only… read more here.
Keywords: gastric carcinoma; gastric cancers; etiology; genomic pathobiology ... See more keywords
BRCA2 Germline Mutations Identify Gastric Cancers Responsive to PARP Inhibitors
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/0008-5472.can-22-2620
Abstract: PARP inhibition is a potential strategy for treating patients with gastric cancer with mutated BRCA2 or homologous repair deficiency, including patients with familial intestinal gastric cancer, for whom BRCA2 germline testing should be recommended. read more here.
Keywords: brca2 germline; mutations identify; germline mutations; gastric cancers ... See more keywords
Abstract 2701: Proteogenomic analysis of endoscopy biopsy identifies alterations in apoptotic pathways in trastuzumab-resistant gastric cancers
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-2701
Abstract: Although the combination of trastuzumab with cisplatin and fluoropyrimidine is standard therapy for metastatic HER2-positive gastric cancers, predictive biomarkers for this therapy need to be further refined. Given the multifactorial nature of clinical trastuzumab resistance,… read more here.
Keywords: biopsy; gastric cancers; resistant tumors; alterations apoptotic ... See more keywords