The Oral Bioavailability and Effect of Various Gastric Conditions on the Pharmacokinetics of Dersimelagon in Healthy Adult Volunteers
Sign Up to like & getrecommendations! Published in 2023 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.1235
Abstract: Dersimelagon is a novel orally administered selective agonist for melanocortin receptor 1 being investigated for the treatment of erythropoietic protoporphyria, X‐linked protoporphyria, and diffuse cutaneous systemic sclerosis. In this open‐label, multicenter, randomized, two‐cohort, sequential crossover… read more here.
Keywords: oral bioavailability; various gastric; bioavailability; effect various ... See more keywords
Accurate and sensitive determination of sildenafil, tadalafil, vardenafil, and avanafil in illicit erectile dysfunction medications and human urine by LC with quadrupole-TOF-MS/MS and their behaviors in simulated gastric conditions.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of separation science"
DOI: 10.1002/jssc.201800734
Abstract: The widespread use of phosphodiesterase-5 inhibitors has attracted broad attention of counterfeiters to develop illicit erectile products with inaccurate amounts, unknown toxicity, and purity of active ingredients. Correspondingly, intake of these products endangers consumer health… read more here.
Keywords: human urine; medications human; determination; gastric conditions ... See more keywords
A pectin-gelatin gel containing oral rehydration solution and the release of sodium chloride under simulated gastric conditions.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2019.06.146
Abstract: Both gelatin and pectin have the ability to trap salt and facilitate its release under simulated gastric conditions. The objective of this study was to develop a pectin-gelatin gel fortified with oral rehydration solution/s (ORS)… read more here.
Keywords: pectin gelatin; salt; gastric conditions; gel ... See more keywords
In Vitro Simulation of the Fasted Gastric Conditions and Their Variability to Elucidate Contrasting Properties of the Marketed Dabigatran Etexilate Pellet-Filled Capsules and Loose Pellets.
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DOI: 10.1021/acs.molpharmaceut.4c00025
Abstract: Variability of the gastrointestinal tract is rarely reflected in in vitro test protocols but often turns out to be crucial for the oral dosage form performance. In this study, we present a generation method of… read more here.
Keywords: fasted gastric; variability; filled capsules; dissolution ... See more keywords
Improving the survival under gastric conditions of a potential multistrain probiotic produced in co-culture
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DOI: 10.1186/s13568-024-01810-4
Abstract: Process and culture medium composition in bioreactor could be optimized in order to find the best conditions that improve survival of probiotic microorganism under exposure to gastric conditions such low pH and bile salts. Therefore,… read more here.
Keywords: antagonistic activity; culture; gastric conditions; survival gastric ... See more keywords