Helicobacter pylori-induced RASAL2 through activation of NF-kB promotes gastric tumorigenesis via β-catenin signaling axis.
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DOI: 10.1053/j.gastro.2022.01.046
Abstract: BACKGROUND & AIMS Helicobacter pylori (H. pylori) infection is the predominant risk factor for gastric cancer. RAS protein activator like 2 (RASAL2) is considered a double-edged sword in carcinogenesis. Herein, we investigated the role of… read more here.
Keywords: gastric tumorigenesis; catenin; helicobacter pylori; signaling axis ... See more keywords
Krüppel-like factor 2 suppresses human gastric tumorigenesis through inhibiting PTEN/AKT signaling
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DOI: 10.18632/oncotarget.22229
Abstract: Krüppel-like factors (KLFs) are a large family of DNA-binding transcriptional regulators that affect basic cellular processes such as growth, survival, migration and differentiation and serve a complicated function in cancers. KLF2, one member of the… read more here.
Keywords: pten akt; gastric tumorigenesis; expression; human gastric ... See more keywords
Inhibition of N-methyl-N-nitrosourea-induced gastric tumorigenesis by Liuwei Dihuang Pill in db/db mice
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DOI: 10.3748/wjg.v23.i23.4233
Abstract: AIM To investigate the inhibitory effect of Liuwei Dihuang Pill (LDP) on gastric tumorigenesis induced by N-methyl-N-nitrosourea (MNU) in diabetic mice. METHODS Four-week-old mice were divided into four groups: A, 12 db/m mice treated with… read more here.
Keywords: gastric tumorigenesis; mice treated; mice; dihuang pill ... See more keywords
PRMT5 acts as a tumor suppressor by inhibiting Wnt/β-catenin signaling in murine gastric tumorigenesis
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DOI: 10.7150/ijbs.71581
Abstract: Previous studies have demonstrated the in vitro oncogenic role of protein arginine methyltransferase 5 (PRMT5) in gastric cancer cell lines. The in vivo function of PRMT5 in gastric tumorigenesis, however, is still unexplored. Here, we… read more here.
Keywords: prmt5; gastric tumorigenesis; gastric cancer; tumor ... See more keywords