Amorphous solid dispersions of weak bases with pH-dependent soluble polymers to overcome limited bioavailability due to gastric pH variability - An in-vitro approach.
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DOI: 10.1016/j.ijpharm.2019.04.034
Abstract: Several drugs are pH-dependent soluble weak bases with a poor solubility in the intestinal pH range. Additionally a variable gastric pH, which is a common issue in the population, potentially reduces the in-vivo performance due… read more here.
Keywords: dependent soluble; gastric variability; weak bases; solid dispersions ... See more keywords