Comparative cell uptake study of FITC-/177Lu-labeled RM26 monomer, dimer and trimer on PC-3: improving binding affinity of gastrin releasing peptide receptor (GRPR) antagonist via bivalency/trivalency
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Radioanalytical and Nuclear Chemistry"
DOI: 10.1007/s10967-018-6396-x
Abstract: The gastrin releasing peptide receptors (GRPRs) overexpress in various tumors, which provided the opportunity for GRPR targeted tumor radiological diagnosis and therapy. In recent reports, the GPPR antagonists presented superior specific targeting affinity over the… read more here.
Keywords: affinity; releasing peptide; dimer trimer; binding affinity ... See more keywords
The effects of a growth hormone-releasing hormone antagonist and a gastrin-releasing peptide antagonist on intimal hyperplasia of the carotid artery after balloon injury in a diabetic rat model
Sign Up to like & getrecommendations! Published in 2017 at "Artery Research"
DOI: 10.1016/j.artres.2017.06.006
Abstract: Abstract Introduction Arterial restenosis after angioplasty/stenting has hindered coronary artery disease treatment, especially in diabetics. We theorized that gastrin-releasing peptide (GRP) antagonists and growth hormone-releasing hormone (GHRH) antagonists might decrease neointimal hyperplasia and restenosis in… read more here.
Keywords: artery; releasing peptide; antagonist; growth ... See more keywords
Gastrin-releasing peptide induces monocyte adhesion to vascular endothelium by upregulating endothelial adhesion molecules.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.01.058
Abstract: Gastrin-releasing peptide (GRP) is a neuropeptide that plays roles in various pathophysiological conditions including inflammatory diseases in peripheral tissues; however, little is known about whether GRP can directly regulate endothelial inflammatory processes. In this study,… read more here.
Keywords: grp; endothelium; releasing peptide; adhesion ... See more keywords
Functional roles of neuromedin B and gastrin-releasing peptide in regulating itch and pain in the spinal cord of non-human primates.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2022.114972
Abstract: Despite accumulating evidence in rodents, the functional role of neuromedin B (NMB) in regulating somatosensory systems in primate spinal cord is unknown. We aimed to compare the expression patterns of NMB and its receptor (NMBR)… read more here.
Keywords: gastrin releasing; itch pain; itch; spinal cord ... See more keywords
Distribution of the pig gastrin-releasing peptide receptor and the effect of GRP on porcine Leydig cells
Sign Up to like & getrecommendations! Published in 2018 at "Peptides"
DOI: 10.1016/j.peptides.2017.09.015
Abstract: ABSTRACT Gastrin‐releasing peptide (GRP) is a mammalian bombesin (BN)‐like peptide which plays a role in a number of important physiological functions via its receptor (gastrin‐releasing peptide receptor, GRPR) in most animals. However, little is known… read more here.
Keywords: pig; grp; grpr mrna; releasing peptide ... See more keywords
Gastrin-releasing peptide regulates fear learning under stressed conditions via activation of the amygdalostriatal transition area
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Psychiatry"
DOI: 10.1038/s41380-021-01408-3
Abstract: The amygdala, a critical brain region responsible for emotional behavior, is crucially involved in the regulation of the effects of stress on emotional behavior. In the mammalian forebrain, gastrin-releasing peptide (GRP), a 27-amino-acid mammalian neuropeptide,… read more here.
Keywords: stress; gastrin releasing; transition area; releasing peptide ... See more keywords
A novel peptide targeting gastrin releasing peptide receptor for pancreatic neoplasm detection.
Sign Up to like & getrecommendations! Published in 2020 at "Biomaterials science"
DOI: 10.1039/d0bm00162g
Abstract: Pancreatic cancer has a high mortality rate and efforts towards diagnosis and therapy at an early stage are particularly appealing. Recently, a small peptide, BBN7-14, has attracted much attention for its specific binding ability to… read more here.
Keywords: bbn7; novel peptide; pancreatic cancer; cancer ... See more keywords
Structures of human gastrin-releasing peptide receptors bound to antagonist and agonist for cancer and itch therapy.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2216230120
Abstract: Gastrin releasing peptide receptor (GRPR), a member of the bombesin (BBN) G protein-coupled receptors, is aberrantly overexpressed in several malignant tumors, including those of the breast, prostate, pancreas, lung, and central nervous system. Additionally, it… read more here.
Keywords: itch therapy; cancer itch; releasing peptide; itch ... See more keywords
Photoacoustic signal enhancement in dual-contrast gastrin-releasing peptide receptor-targeted nanobubbles
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2023.1102651
Abstract: Translatable imaging agents are a crucial element of successful molecular imaging. Photoacoustic molecular imaging relies on optical absorbing materials to generate a sufficient signal. However, few materials approved for human use can generate adequate photoacoustic… read more here.
Keywords: molecular imaging; releasing peptide; enhancement; photoacoustic signal ... See more keywords
Gastrin-Releasing Peptide Receptor in Low Grade Prostate Cancer: Can It Be a Better Predictor Than Prostate-Specific Membrane Antigen?
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.650249
Abstract: The aim of the present study was to evaluate whether prostate cancer (PC) patients can be accurately classified on the bases of tissue expression of gastrin-releasing peptide receptor (GRPR) and prostate-specific membrane antigen (PSMA). This… read more here.
Keywords: prostate; releasing peptide; prostate cancer; expression ... See more keywords
Targeting the Gastrin-Releasing Peptide Receptor (GRP-R) in Cancer Therapy: Development of Bombesin-Based Peptide–Drug Conjugates
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24043400
Abstract: Targeted tumour therapy has proved to be an efficient alternative to overcome the limitations of conventional chemotherapy. Among several receptors upregulated in cancer cells, the gastrin-releasing peptide receptor (GRP-R) has recently emerged as a promising… read more here.
Keywords: grp; releasing peptide; therapy; drug ... See more keywords