The role of gastrodin in the management of CNS‐related diseases: Underlying mechanisms to therapeutic perspectives
Sign Up to like & getrecommendations! Published in 2024 at "Phytotherapy Research"
DOI: 10.1002/ptr.8314
Abstract: Central nervous system (CNS)‐related diseases have a high mortality rate, are a serious threat to physical and mental health, and have always been an important area of research. Gastrodin, the main active metabolite of Gastrodia… read more here.
Keywords: underlying mechanisms; cns related; cns; related diseases ... See more keywords
Enhancement in mechanical properties and cell activity of polyurethane scaffold derived from gastrodin
Sign Up to like & getrecommendations! Published in 2018 at "Materials Letters"
DOI: 10.1016/j.matlet.2018.06.061
Abstract: Abstract Scaffolds are used in tissue engineering to provide a temporary structural template for cell colonization and matrix formation. Here, an emerging polyurethane (PU) porous scaffold incorporated with renewable gastrodin was developed, and its mechanical… read more here.
Keywords: polyurethane; properties cell; gastrodin; cell activity ... See more keywords
Gastrodin promotes hippocampal neurogenesis via PDE9-cGMP-PKG pathway in mice following cerebral ischemia
Sign Up to like & getrecommendations! Published in 2021 at "Neurochemistry International"
DOI: 10.1016/j.neuint.2021.105171
Abstract: Gastrodin, which is extracted from the Chinese herbal medicine Gastrodia elata Blume, can ameliorate neurogenesis after cerebral ischemia. However, it's possible underlying mechanisms remain still elusive. PDE9-cGMP-PKG signaling pathway is involved in the proliferation of… read more here.
Keywords: cgmp pkg; pde9 cgmp; cerebral ischemia; gastrodin ... See more keywords
Gastrodin regulates the expression of renin‐angiotensin system–SIRT3 and proinflammatory mediators in reactive astrocytes via activated microglia
Sign Up to like & getrecommendations! Published in 2024 at "European Journal of Neuroscience"
DOI: 10.1111/ejn.16371
Abstract: Gastrodin, an anti‐inflammatory herbal agent, is known to suppress microglia activation. Here, we investigated whether it would exert a similar effect in reactive astrocytes and whether it might act through the renin‐angiotensin system (RAS) and… read more here.
Keywords: renin angiotensin; gastrodin; reactive astrocytes; expression ... See more keywords
Gastrodin protects retinal ganglion cells through inhibiting microglial-mediated neuroinflammation in an acute ocular hypertension model.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of ophthalmology"
DOI: 10.18240/ijo.2017.10.01
Abstract: AIM To investigate the neuroprotective effect of gastrodin on retinal ganglion cells (RGCs) in an acute ocular hypertension (AOH) rat model and to identify its possible mechanism. METHODS AOH rat model was performed in a… read more here.
Keywords: acute; retinal ganglion; ganglion cells; gastrodin ... See more keywords
Pleiotropic Actions of Gastrodia Elata Glucosides in the Treatment of Painful Neuropathies and CNS Disorders: Focus on Mitochondrial Dysfunction and Modulation of Ion Channels.
Sign Up to like & getrecommendations! Published in 2025 at "Current neuropharmacology"
DOI: 10.2174/011570159x402568251002112117
Abstract: Glycosides contained in Gastrodia elata have consistently shown neuroprotective and antiinflammatory activity in preclinical models of neurological disorders, including peripheral neuropathies, cerebrovascular disorders, and chronic neurodegenerative disorders. In a commercial product used in Italy, gastrodin… read more here.
Keywords: ion channels; gastrodin; gastrodia elata; ion ... See more keywords
Gastrodin suppresses pyroptosis and exerts neuroprotective effect in traumatic brain injury model by inhibiting NLRP3 inflammasome signaling pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of integrative neuroscience"
DOI: 10.31083/j.jin2102072
Abstract: Traumatic brain injury (TBI), also known as head injury or brain injury, refers to the head injury caused by mechanical impact. It is necessary to develop effective new therapies for TBI injury. Gastrodin (GAS) is… read more here.
Keywords: traumatic brain; gas; brain; gastrodin ... See more keywords
Aspirin in combination with gastrodin protects cardiac function and mitigates gastric mucosal injury in response to myocardial ischemia/reperfusion
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.995102
Abstract: Myocardial ischemia/reperfusion (I/R) injury after percutaneous coronary intervention (PCI) is common in acute myocardial infarction. Aspirin is commonly prescribed as anti-thrombotic therapy with coronary heart disease (CHD). However, long-term use of aspirin causes severe gastric… read more here.
Keywords: cardiac function; combination; gastric mucosal; gastrodin ... See more keywords
Gastrodin attenuates renal injury and collagen deposition via suppression of the TGF-β1/Smad2/3 signaling pathway based on network pharmacology analysis
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1082281
Abstract: Background: Gastrodin has been widely used clinically in China as an antihypertensive drug. However, its effect on hypertensive renal injury is yet to be elucidated. The current study aimed to investigate the effects of gastrodin… read more here.
Keywords: renal injury; pharmacology; collagen; gastrodin ... See more keywords