Evaluation of the Association of Perioperative UGT1A1 Genotype-Dosed gFOLFIRINOX With Margin-Negative Resection Rates and Pathologic Response Grades Among Patients With Locally Advanced Gastroesophageal Adenocarcinoma: A Phase 2 Clinical Trial.
Sign Up to like & getrecommendations! Published in 2020 at "JAMA network open"
DOI: 10.1001/jamanetworkopen.2019.21290
Abstract: Importance Patients with locally advanced gastroesophageal adenocarcinoma (ie, stage ≥T3 and/or node positive) have high rates of recurrence despite surgery and adjunctive perioperative therapies, which also have high toxicity profiles. Evaluation of pharmacogenomically dosed perioperative… read more here.
Keywords: ugt1a1 genotype; genotype; gastroesophageal; patients locally ... See more keywords
Treatment of Gastric and Gastroesophageal Cancers—Do We Really Need Anthracyclines?
Sign Up to like & getrecommendations! Published in 2017 at "JAMA Oncology"
DOI: 10.1001/jamaoncol.2016.3064
Abstract: Combination chemotherapy has been shown to be superior to single-agent therapy in gastric and gastroesophageal cancers. However, there is no consensus regarding the optimal regimen. Epirubicin-containing regimens are considered standard in parts of Europe, but… read more here.
Keywords: treatment gastric; anthracyclines treatment; gastroesophageal; gastric gastroesophageal ... See more keywords
Gastroesophageal Reflux Disease and Aerodigestive Disorders.
Sign Up to like & getrecommendations! Published in 2018 at "Current problems in pediatric and adolescent health care"
DOI: 10.1016/j.cppeds.2018.01.005
Abstract: This relationship between gastroesophageal reflux and airway disorders is complex, possibly bidirectional, and not clearly defined. The tools used to investigate gastroesophageal reflux are mostly informative about involvement of gastroesophageal reflux within the gastrointestinal tract,… read more here.
Keywords: airway disorders; reflux airway; gastroesophageal; reflux disease ... See more keywords
Nivolumab with or without chemotherapy for metastatic gastroesophageal cancers and future perspectives
Sign Up to like & getrecommendations! Published in 2022 at "Expert Review of Anticancer Therapy"
DOI: 10.1080/14737140.2022.2139241
Abstract: ABSTRACT Introduction Gastroesophageal cancers (GEC) are frequently found at the advanced stage. GEC treatment advancements have been limited and prognosis, therefore, remains poor. Through numerous clinical trials, the addition of immune checkpoint inhibitors, including nivolumab,… read more here.
Keywords: nivolumab without; gastroesophageal; chemotherapy metastatic; gastroesophageal cancers ... See more keywords
Early miR-223 Upregulation in Gastroesophageal Carcinogenesis
Sign Up to like & getrecommendations! Published in 2017 at "American Journal of Clinical Pathology"
DOI: 10.1093/ajcp/aqx004
Abstract: Objectives To test miR-223 upregulation during gastric (intestinal-type) and Barrett esophageal carcinogenesis. Methods miR-223 expression was assessed by quantitative reverse transcription polymerase chain reaction in a series of 280 gastroesophageal biopsy samples representative of the… read more here.
Keywords: gastroesophageal; mir 223; carcinogenesis; upregulation ... See more keywords
Quantification of gastroesophageal regurgitation in brachycephalic dogs
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Veterinary Internal Medicine"
DOI: 10.1111/jvim.16400
Abstract: Abstract Background Gastroesophageal reflux and regurgitation occurs in brachycephalic dogs, but objective assessment is lacking. Objectives Quantify reflux in brachycephalic dogs using an esophageal pH probe and determine the association with scored clinical observations. Animals… read more here.
Keywords: brachycephalic dogs; regurgitation; reflux; gastroesophageal ... See more keywords
ctDNA in Gastric and Gastroesophageal Cancer: Prognostic, Predictive, or Preliminary?
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-19-2774
Abstract: In gastric and gastroesophageal adenocarcinoma, circulating tumor DNA identifies molecular drivers missed using routine tumor biopsy, can refine patient selection for targeted therapy, and may be prognostic following surgical resection. However, lack of standardization could… read more here.
Keywords: ctdna gastric; gastric gastroesophageal; cancer prognostic; gastroesophageal ... See more keywords
Recent developments in PD-1/PD-L1 blockade research for gastroesophageal malignancies
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1043517
Abstract: Gastroesophageal cancers (GECs) comprise malignancies in the stomach, esophagus, and gastroesophageal junction. Despite ongoing improvements in chemoradiotherapy, the clinical outcomes of GEC have not significantly improved over the years, and treatment remains challenging. Immune checkpoint… read more here.
Keywords: blockade research; clinical trials; developments blockade; gastroesophageal ... See more keywords
Effect of Dewaxed Coffee on Gastroesophageal Symptoms in Patients with GERD: A Randomized Pilot Study
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DOI: 10.3390/nu14122510
Abstract: Gastroesophageal Reflux Disease (GERD) is multifactorial pathogenesis characterized by the abnormal reflux of stomach contents into the esophagus. Symptoms are worse after the ingestion of certain foods, such as coffee. Hence, a randomized pilot study… read more here.
Keywords: gastroesophageal; coffee; pilot study; randomized pilot ... See more keywords
Efficacy of endoscopic anterior fundoplication with a novel ultrasonic surgical endostapler for gastroesophageal reflux disease: Six-month results from a multicenter prospective trial
Sign Up to like & getrecommendations! Published in 2022 at "Endoscopic Ultrasound"
DOI: 10.4103/eus-d-21-00244
Abstract: ABSTRACT Background and Objectives: Endoscopic therapy is an option for the treatment of refractory gastroesophageal reflux disease (GERD). We aimed to evaluate the efficacy and safety of transoral incisionless fundoplication with the Medigus ultrasonic surgical… read more here.
Keywords: fundoplication; reflux disease; efficacy; gastroesophageal ... See more keywords
A Novel Technique for Prevention of Gastroesophageal Reflux in Staged Repair of Long Gap Esophageal Atresia with Tracheoesophageal Fistula
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Indian Association of Pediatric Surgeons"
DOI: 10.4103/jiaps.jiaps_239_18
Abstract: Aim: The objective of the study is to report a novel technique of preventing gastroesophageal reflux and air leak from fistula to stomach in patients of tracheoesophageal fistula with long gap atresia, to buy time… read more here.
Keywords: gastroesophageal reflux; tracheoesophageal fistula; novel technique; long gap ... See more keywords