Outcomes and Molecular Features of Brain Metastasis in Gastroesophageal Adenocarcinoma
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.28083
Abstract: Key Points Question What clinical features are associated with survival in patients with brain metastasis from gastroesophageal adenocarcinoma? Findings In this cohort study of 68 patients with brain metastasis from gastroesophageal adenocarcinoma, median survival was… read more here.
Keywords: gastroesophageal adenocarcinoma; brain metastasis; metastasis gastroesophageal;
Adherence to and determinants of guideline‐recommended biomarker testing and targeted therapy in patients with gastroesophageal adenocarcinoma: Insights from routine practice
Sign Up to like & getrecommendations! Published in 2021 at "Cancer"
DOI: 10.1002/cncr.33514
Abstract: Anti human epidermal growth factor receptor 2 (anti‐HER2) therapy with trastuzumab improves overall survival in patients with advanced, HER2‐positive gastroesophageal adenocarcinoma (GEA) and is now incorporated into national guidelines. However, little is known about adherence… read more here.
Keywords: routine practice; gastroesophageal adenocarcinoma; adherence determinants; therapy ... See more keywords
Association between timely targeted treatment and outcomes in patients with metastatic HER2‐overexpressing gastroesophageal adenocarcinoma
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DOI: 10.1002/cncr.34117
Abstract: Timely targeted treatment initiation can be challenging because additional biomarker testing is needed for eligibility. The authors hypothesized that timely targeted treatment improves survival relative to nontimely initiation in metastatic HER2+ gastroesophageal adenocarcinoma (GEA). read more here.
Keywords: gastroesophageal adenocarcinoma; metastatic her2; timely targeted; targeted treatment ... See more keywords
Gastroesophageal adenocarcinoma in older adults: A comprehensive narrative review of management by the young international society of geriatric oncology.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of geriatric oncology"
DOI: 10.1016/j.jgo.2021.09.006
Abstract: Gastroesophageal adenocarcinoma is a disease of older adults with very poor survival rates. Its incidence has risen dramatically across the world in recent decades. Current treatment approaches for older adults are based largely on extrapolated… read more here.
Keywords: gastroesophageal adenocarcinoma; oncology; older adults; geriatric oncology ... See more keywords
Abstract 5959: Dissecting the stromal drivers of gastroesophageal adenocarcinoma chemoresistance
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-5959
Abstract: Gastroesophageal adenocarcinoma (GEA) is the fastest rising cancer in North America. Over the course of five years, the survival rate is 200 GEA patients. A single-cell RNA sequencing atlas developed from >30 GEA DCF- or… read more here.
Keywords: gastroesophageal adenocarcinoma; tumor; dissecting stromal; response ... See more keywords
Genomic Heterogeneity as a Barrier to Precision Medicine in Gastroesophageal Adenocarcinoma.
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DOI: 10.1158/2159-8290.cd-17-0395
Abstract: Gastroesophageal adenocarcinoma (GEA) is a lethal disease where targeted therapies, even when guided by genomic biomarkers, have had limited efficacy. A potential reason for the failure of such therapies is that genomic profiling results could… read more here.
Keywords: medicine; precision medicine; genomic heterogeneity; heterogeneity ... See more keywords
Localized Gastroesophageal Adenocarcinoma in the Elderly: Is Age a Factor Associated with Suboptimal Treatment?
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DOI: 10.1159/000525927
Abstract: Introduction: Gastroesophageal adenocarcinoma is relatively common in elderly patients as the incidence increases with age. However, the optimal treatment approach is not well established in this group of patients. The aim of this study is… read more here.
Keywords: oncology; gastroesophageal adenocarcinoma; age; localized gastroesophageal ... See more keywords
Next generation sequencing in gastric or gastroesophageal adenocarcinoma.
Sign Up to like & getrecommendations! Published in 2020 at "Translational gastroenterology and hepatology"
DOI: 10.21037/tgh.2020.01.09
Abstract: Seminal analyses of The Cancer Genome Atlas (TGCA) and Asian Cancer Research Group (ACRG) have provided unprecedented insight into the molecular underpinnings of gastric cancer (GC). At the same time, next generation sequencing (NGS) panels,… read more here.
Keywords: sequencing gastric; gastroesophageal adenocarcinoma; next generation; generation sequencing ... See more keywords
Tumor-Associated CD68+, CD163+, and MARCO+ Macrophages as Prognostic Biomarkers in Patients With Treatment-Naïve Gastroesophageal Adenocarcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2020.534761
Abstract: Background: Despite improvements in surgical methodologies and perioperative chemo- and radiotherapy, the prognosis for patients with esophageal and gastric cancer remains poor. Hence, there is a great need to identify complementary biomarkers for improved treatment… read more here.
Keywords: gastroesophageal adenocarcinoma; cd163 marco; cd68 cd163; cd163 ... See more keywords
(Neo)Adjuvant Treatment of Locally Advanced Esophageal and Gastroesophageal Adenocarcinoma: Special Focus on Sex Differences
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DOI: 10.3390/cancers14041088
Abstract: Simple Summary Multimodal therapy is standard in locally advanced esophageal and gastroesophageal adenocarcinoma. Although substantial differences in incidence and outcome between women and men have been observed, no clear sex-specific treatment guide has been developed.… read more here.
Keywords: locally advanced; esophageal gastroesophageal; gastroesophageal adenocarcinoma; advanced esophageal ... See more keywords
Putative Clinical Potential of ERBB2 Amplification Assessment by ddPCR in FFPE-DNA and cfDNA of Gastroesophageal Adenocarcinoma Patients
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DOI: 10.3390/cancers14092180
Abstract: Simple Summary Gastroesophageal adenocarcinoma (GEA) has a poor prognosis. However, since the HER2 positive subgroup could benefit from trastuzumab targeted therapy, considerable effort has been spent in determining the HER2 status in these patients. To… read more here.
Keywords: ddpcr; gastroesophageal adenocarcinoma; erbb2 amplification; cfdna ... See more keywords