Efficacy and safety of a novel anti-HER2 therapeutic antibody RC48 in patients with HER2-overexpressing, locally advanced or metastatic gastric or gastroesophageal junction cancer: a single-arm phase II study.
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DOI: 10.1002/cac2.12214
Abstract: BACKGROUND Current treatment options for human epidermal growth factor receptor 2 (HER2)-overexpressing gastric cancer at third-line have shown limited clinical benefit. Further, there is no specific treatment for HER2 immunohistochemistry (IHC) 2+ and fluorescence in-situ… read more here.
Keywords: patients her2; her2 overexpressing; junction cancer; gastroesophageal junction ... See more keywords
Optimal management of gastroesophageal junction cancer
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DOI: 10.1002/cncr.32066
Abstract: Although recent decades have witnessed incremental improvements in the treatment of gastroesophageal junction (GEJ) carcinoma, outcomes remain modest. For locally advanced esophageal cancer, the addition of chemotherapy and/or radiation to surgery is considered the standard… read more here.
Keywords: management; gastroesophageal junction; cancer optimal; cancer ... See more keywords
Top advances in esophageal/gastroesophageal junction cancers in 2021
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DOI: 10.1002/cncr.34140
Abstract: INTRODUCTION After almost a decade of limited progress in the treatment of esophagogastric cancer (EGC), which includes both esophageal squamous cell carcinoma (ESCC) and esophagogastric adenocarcinoma (EAC), groundbreaking improvements in clinically meaningful outcomes were made… read more here.
Keywords: cancers 2021; esophageal gastroesophageal; junction cancers; gastroesophageal junction ... See more keywords
PD‐L1 expression in gastric and gastroesophageal junction cancer patients treated with perioperative chemotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Surgical Oncology"
DOI: 10.1002/jso.26929
Abstract: The incidence, predictive, and prognostic impact of programmed cell death (PD‐L1) expression in gastric (GC) and gastroesophageal junction tumors (GEJC) treated with perioperative chemotherapy is poorly understood. We aimed to assess PD‐L1 expression by immunohistochemistry… read more here.
Keywords: treated perioperative; gastroesophageal junction; expression; perioperative chemotherapy ... See more keywords
Tissue engineering of the gastroesophageal junction
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DOI: 10.1002/term.3045
Abstract: The gastroesophageal junction has been of clinical interest for some time due to its important role in preventing reflux of caustic stomach contents upward into the esophagus. Failure of this role has been identified as… read more here.
Keywords: engineering; engineering gastroesophageal; tissue; gastroesophageal junction ... See more keywords
Surgical approaches to adenocarcinoma of the gastroesophageal junction: the Siewert II conundrum
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DOI: 10.1007/s00423-017-1610-9
Abstract: BackgroundThe Siewert classification system for gastroesophageal junction adenocarcinoma has provided morphological and topographical information to help guide surgical decision-making. Evidence has shown that Siewert I and III tumors are distinct entities with differing epidemiologic and… read more here.
Keywords: approaches adenocarcinoma; siewert; surgical approaches; gastroesophageal junction ... See more keywords
Pembrolizumab alone or in combination with chemotherapy as first-line therapy for patients with advanced gastric or gastroesophageal junction adenocarcinoma: results from the phase II nonrandomized KEYNOTE-059 study
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DOI: 10.1007/s10120-018-00909-5
Abstract: BackgroundThe multicohort, phase II, nonrandomized KEYNOTE-059 study evaluated pembrolizumab ± chemotherapy in advanced gastric/gastroesophageal junction cancer. Results from cohorts 2 and 3, evaluating first-line therapy, are presented.MethodsPatients ≥ 18 years old had previously untreated recurrent or metastatic gastric/gastroesophageal junction… read more here.
Keywords: therapy; combination; gastroesophageal junction; gastric gastroesophageal ... See more keywords
Survival after neoadjuvant approaches to gastroesophageal junction cancer
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DOI: 10.1007/s10120-019-00980-6
Abstract: Background Gastroesophageal junction (GEJ) cancers can be treated with equipoise using neoadjuvant chemoradiation (NACRT) or chemotherapy alone (NAC), but the comparative outcomes are unclear. Methods Patients with non-metastatic T2-4 or N1-3 GEJ adenocarcinoma who underwent… read more here.
Keywords: chemotherapy; gastroesophageal junction; cancer; nacrt nac ... See more keywords
Significance of blood neutrophil-to-lymphocyte ratio for prognostic stratification of patients with gastroesophageal junction adenocarcinoma in the era of the 8th edition of the American Joint Committee on Cancer (AJCC8) staging
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DOI: 10.1007/s12032-017-0976-4
Abstract: The prognosis of patients with gastroesophageal junction (GOJ) adenocarcinoma depends mainly on the clinical staging, as described by the new AJCC8 (American Joint Committee on Cancer 8th edition). Evidence suggests that peripheral blood neutrophil-to-lymphocyte ratio… read more here.
Keywords: clinical staging; patients gastroesophageal; american joint; gastroesophageal junction ... See more keywords
Mucosal Schwann cell hamartoma of the gastroesophageal junction: A series of 6 cases and comparison with colorectal counterpart.
Sign Up to like & getrecommendations! Published in 2020 at "Annals of diagnostic pathology"
DOI: 10.1016/j.anndiagpath.2020.151531
Abstract: Mucosal Schwann cell hamartoma (MSCH) is an uncommon neural lesion characterized by an ill-defined proliferation of S100-positive Schwann cells in the lamina propria, with reported cases exclusively occurring in the colorectum. Here we describe the… read more here.
Keywords: schwann; mucosal schwann; cell hamartoma; pathology ... See more keywords
Laparoscopic transgastric resection for intraluminal gastric gastrointestinal stromal tumors located at the posterior wall and near the gastroesophageal junction.
Sign Up to like & getrecommendations! Published in 2017 at "Asian journal of surgery"
DOI: 10.1016/j.asjsur.2015.12.001
Abstract: OBJECTIVE Intraluminal gastric gastrointestinal stromal tumors (GISTs) located at the posterior wall and near the gastroesophageal junction represent a surgical challenge. We present our experience of laparoscopic transgastric resection for gastric GISTs of such location.… read more here.
Keywords: transgastric resection; laparoscopic transgastric; posterior wall; gastroesophageal junction ... See more keywords