Clozapine-Induced Gastrointestinal Hypomotility: A 22-Year Bi-National Pharmacovigilance Study of Serious or Fatal ‘Slow Gut’ Reactions, and Comparison with International Drug Safety Advice
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DOI: 10.1007/s40263-017-0448-6
Abstract: IntroductionClozapine is the preferred antipsychotic for treatment-resistant schizophrenia, but has significant adverse effects, including gastrointestinal hypomotility or ‘slow gut’, which may result in severe constipation, ileus, bowel obstruction, and even death. These gastrointestinal effects remain… read more here.
Keywords: clozapine; clozapine induced; slow gut; study ... See more keywords
Clozapine and Gastrointestinal Hypomotility
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DOI: 10.1007/s40263-017-0481-5
Abstract: Gastrointestinal hypomotility (GIH) is an under-reported but highly prevalent and potentially dangerous side effect of clozapine. In a comprehensive meta-analysis of clozapine-treated patients, the prevalence of GIH was 32%. In general, GIH has consistently been… read more here.
Keywords: clozapine treated; gastrointestinal hypomotility; treatment; gih ... See more keywords
Reporting of clozapine-induced gastrointestinal hypomotility and factors associated with fatal outcomes in Canada: A pharmacovigilance database study
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DOI: 10.1016/j.psychres.2020.113048
Abstract: Clozapine-induced gastrointestinal hypomotility (CIGH) is poorly understood and potentially life-threatening. Herein, we present trends of CIGH annual reporting and explore factors associated with a fatal outcome using 25-years of pharmacovigilance data in Canada. Since 1993,… read more here.
Keywords: clozapine; clozapine induced; factors associated; associated fatal ... See more keywords