Immunotherapy in Gastrointestinal Malignancies.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-41008-7_5
Abstract: Gastrointestinal (GI) cancers represent a variety of malignancies, each with a unique interplay between the tumor and local immune microenvironment. The successes that immunotherapy, particularly immune checkpoint inhibition, has brought to various other solid tumors… read more here.
Keywords: therapy; immunotherapy gastrointestinal; gastrointestinal malignancies; biology ... See more keywords
Ytrrium-90 transarterial radioembolization in patients with gastrointestinal malignancies
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Translational Oncology"
DOI: 10.1007/s12094-021-02745-z
Abstract: Transarterial radioembolization (TARE) with yttrium-90 (Y90) is a promising alternative strategy to treat liver tumors and liver metastasis from colorectal cancer (CRC), as it selectively delivers radioactive isotopes to the tumor via the hepatic artery,… read more here.
Keywords: tare; transarterial radioembolization; ytrrium transarterial; gastrointestinal malignancies ... See more keywords
Microbiome and gastrointestinal malignancies
Sign Up to like & getrecommendations! Published in 2021 at "Current Opinion in Physiology"
DOI: 10.1016/j.cophys.2021.06.005
Abstract: Microbiota plays an important role in gut homeostasis and immunity against pathogens. However, the dysbiosis of gut microbiota increases the susceptibility of the host to pathogens leading to the development of several diseases including gastrointestinal… read more here.
Keywords: gastrointestinal malignancies; gut microbiota; host; microbiome gastrointestinal ... See more keywords
Epigenetics and therapeutic targets in gastrointestinal malignancies.
Sign Up to like & getrecommendations! Published in 2021 at "Drug discovery today"
DOI: 10.1016/j.drudis.2021.04.013
Abstract: Gastrointestinal (GI) malignancies account for substantial mortality and morbidity worldwide. They are generally promoted by dysregulated signal transduction and epigenetic pathways, which are controlled by specific enzymes. Recent studies demonstrated that histone deacetylases (HDACs) together… read more here.
Keywords: epigenetics therapeutic; gastrointestinal malignancies; targets gastrointestinal; therapeutic targets ... See more keywords
Novel Radiotherapy Technologies in the Treatment of Gastrointestinal Malignancies.
Sign Up to like & getrecommendations! Published in 2020 at "Hematology/oncology clinics of North America"
DOI: 10.1016/j.hoc.2019.08.016
Abstract: Over the past 2 decades, major technical advances in radiation therapy planning and delivery have made it possible to deliver higher doses to select high-risk volumes. This has helped to expand the role of radiation therapy… read more here.
Keywords: novel radiotherapy; gastrointestinal malignancies; treatment gastrointestinal; treatment ... See more keywords
PS02.229: ASSESSMENT OF VARYING QUALITY OF LIFE OUTCOMES BASED ON A STRATEGY OF ORGAN PRESERVATION VERSUS SURGERY FOR UPPER GASTROINTESTINAL MALIGNANCIES
Sign Up to like & getrecommendations! Published in 2018 at "Diseases of the Esophagus"
DOI: 10.1093/dote/doy089.ps02.229
Abstract: Neoadjuvant chemoradiotherapy (naCRT) for upper gastrointestinal malignancies induces a pathological complete response (pCR) in 25–85% of patients, depending on disease stage and regimen chosen. All patients with a pCR will have a clinical complete response… read more here.
Keywords: surgery; gastrointestinal malignancies; upper gastrointestinal; group ... See more keywords
The Mutational Landscape of Gastrointestinal Malignancies as Reflected by Circulating Tumor DNA
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.mct-17-0360
Abstract: We aimed to assess the utility of a novel, noninvasive method of detecting genomic alterations in patients with gastrointestinal malignancies, i.e., the use of liquid biopsies to obtain blood-derived circulating tumor DNA (ctDNA) through an… read more here.
Keywords: gastrointestinal malignancies; circulating tumor; tumor dna; characterized alterations ... See more keywords
Utility of tumor-informed circulating tumor DNA in the clinical management of gastrointestinal malignancies.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of gastrointestinal oncology"
DOI: 10.21037/jgo-21-484
Abstract: Background Gastrointestinal (GI) malignancies represent a heterogeneous group of diseases. Traditional tumor markers, though part of standard-of-care, lack sensitivity and specificity. Tumor-informed circulating tumor DNA (ctDNA) assay-based molecular residual disease assessment as well as recurrence… read more here.
Keywords: tumor; circulating tumor; tumor informed; tumor dna ... See more keywords
Upper gastrointestinal malignancies in 2017: current perspectives and future approaches.
Sign Up to like & getrecommendations! Published in 2018 at "Future oncology"
DOI: 10.2217/fon-2017-0597
Abstract: The advent of immune checkpoint inhibitors (PD-1, PD-L1 and CTLA-4) has resulted in unprecedented long-term remissions of unresectable cancers. The efficacy of checkpoint inhibitors was recently demonstrated in gastrointestinal malignancies with mismatch repair deficiencies (dMMR).… read more here.
Keywords: malignancies 2017; 2017 current; gastrointestinal malignancies; upper gastrointestinal ... See more keywords
Immune checkpoint inhibitors in luminal gastrointestinal malignancies: going beyond MSI-H/dMMR, TMB and PD-L1.
Sign Up to like & getrecommendations! Published in 2022 at "Immunotherapy"
DOI: 10.2217/imt-2022-0012
Abstract: In luminal gastrointestinal tumors, immune checkpoint inhibitors (ICIs) targeting PD-1, PD-L1 and CTLA-4 have been investigated in multiple settings. The indications for these drugs are primarily dependent on specific biomarkers that imply immunogenicity: overexpression of PD-L1,… read more here.
Keywords: checkpoint inhibitors; luminal gastrointestinal; immune checkpoint; gastrointestinal malignancies ... See more keywords
A topography of immunotherapies against gastrointestinal malignancies.
Sign Up to like & getrecommendations! Published in 2021 at "Panminerva medica"
DOI: 10.23736/s0031-0808.21.04541-9
Abstract: Gastrointestinal (GI) cancers are one of the leading causes of death worldwide. Although various approaches are implemented to improve the health condition of GI patients, none of the treatment protocols promise for eradicating cancer. However,… read more here.
Keywords: immune system; topography; immunotherapies gastrointestinal; gastrointestinal malignancies ... See more keywords