Cost-effectiveness Analysis of Genetic Testing and Tailored First-Line Therapy for Patients With Metastatic Gastrointestinal Stromal Tumors
Sign Up to like & getrecommendations! Published in 2020 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2020.13565
Abstract: Key Points Question Is targeted gene testing cost-effective in patients with metastatic gastrointestinal stromal tumor? Findings This economic evaluation developed a Markov model to examine the cost-effectiveness of targeted gene testing with tailored imatinib dosing… read more here.
Keywords: metastatic gastrointestinal; patients metastatic; gastrointestinal stromal; testing tailored ... See more keywords
18F-Fluorodeoxyglucose Uptake in PDGFRA-Mutant Gastrointestinal Stromal Tumors
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DOI: 10.1001/jamanetworkopen.2024.56058
Abstract: Key Points Question What is the clinical role of positron emission tomography (PET) with 18F-fluorodeoxyglucose ([18F]FDG) in platelet-derived growth factor receptor α (PDGFRA)–mutant gastrointestinal stromal tumor (GIST), especially in the D842V-mutant subgroup? Findings In this… read more here.
Keywords: mutant gastrointestinal; pdgfra mutant; 18f fluorodeoxyglucose; 18f fdg ... See more keywords
Nintedanib overcomes drug resistance from upregulation of FGFR signaling and imatinib-induced KIT mutations in gastrointestinal stromal tumors.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular oncology"
DOI: 10.1002/1878-0261.13199
Abstract: Drug resistance remains a major challenge in the clinical treatment of gastrointestinal stromal tumors (GISTs). While acquired on-target mutations of mast/stem cell growth factor receptor (KIT) kinase is the major resistance mechanism, activation of alternative… read more here.
Keywords: imatinib; stromal tumors; kit mutations; resistance ... See more keywords
Prediction of morbidity following cytoreductive surgery for metastatic gastrointestinal stromal tumour in patients on tyrosine kinase inhibitor therapy
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DOI: 10.1002/bjs.10774
Abstract: Although cytoreductive surgery has been shown to be beneficial in carefully selected patients with metastatic gastrointestinal stromal tumours (GISTs) treated with tyrosine kinase inhibitors (TKIs), factors predictive of postoperative morbidity have not been investigated previously. read more here.
Keywords: surgery; metastatic gastrointestinal; gastrointestinal stromal; cytoreductive surgery ... See more keywords
Relationship between R1 resection, tumour rupture and recurrence in resected gastrointestinal stromal tumour
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DOI: 10.1002/bjs.11027
Abstract: According to guidelines, adjuvant treatment or re‐excision should be considered after R1 resection of gastrointestinal stromal tumours (GISTs). However, the prognostic significance of R1 resection is uncertain and tumour rupture confounds its assessment. Here, the… read more here.
Keywords: relationship resection; tumour rupture; tumour; gastrointestinal stromal ... See more keywords
A correlation research of Ki67 index, CT features, and risk stratification in gastrointestinal stromal tumor
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Medicine"
DOI: 10.1002/cam4.1737
Abstract: Recurrence and metastasis are the most important factors affecting the quality of life and survival rate of patients with gastrointestinal stromal tumors (GISTs). Accurate preoperative determination of the malignant degree of GISTs and the development… read more here.
Keywords: correlation research; research ki67; ki67 index; gastrointestinal stromal ... See more keywords
Diagnosing gastrointestinal stromal tumors: The utility of fine‐needle aspiration cytology versus biopsy
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DOI: 10.1002/cam4.4630
Abstract: Gastrointestinal stromal tumors (GIST) are mesenchymal tumors in the intestinal tract originating from a precursor to the interstitial cells of Cajal, which plays a role in gastric motility. The preoperative diagnosis of GIST may be… read more here.
Keywords: diagnosing gastrointestinal; stromal tumors; utility fine; tumors utility ... See more keywords
Long‐term outcome of dasatinib first‐line treatment in gastrointestinal stromal tumor: A multicenter, 2‐stage phase 2 trial (Swiss Group for Clinical Cancer Research 56/07)
Sign Up to like & getrecommendations! Published in 2018 at "Cancer"
DOI: 10.1002/cncr.31234
Abstract: Tyrosine kinase inhibitors (TKIs) have improved the outcome of patients with gastrointestinal stromal tumors (GISTs), but most patients eventually develop resistance and progress. Dasatinib is a potent inhibitor of BCR‐ABL, KIT, and SRC family kinases… read more here.
Keywords: term outcome; long term; dasatinib; gastrointestinal stromal ... See more keywords
Imatinib adherence prediction using machine learning approach in patients with gastrointestinal stromal tumor
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DOI: 10.1002/cncr.35548
Abstract: Nonadherence to imatinib is common in patients with gastrointestinal stromal tumor (GIST), which is associated with poor prognosis and financial burden. The primary aim of this study was to investigate the adherence rate in patients… read more here.
Keywords: patients gastrointestinal; machine learning; adherence; gastrointestinal stromal ... See more keywords
Ki‐67 index assessment on FNA specimens of gastrointestinal stromal tumor: Correlation with mitotic rate and potential predictive value for risk stratification
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Cytopathology"
DOI: 10.1002/cncy.22630
Abstract: Risk assessment of gastrointestinal stromal tumor (GIST) is challenging on cytology specimens. This study aims to determine whether Ki‐67 index evaluated on fine‐needle aspiration (FNA) specimens can correlate with the mitotic rate of GIST in… read more here.
Keywords: mitotic rate; stromal tumor; assessment; fna specimens ... See more keywords
FGFR2::TACC2 fusion as a novel KIT‐independent mechanism of targeted therapy failure in a multidrug‐resistant gastrointestinal stromal tumor
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.1002/gcc.23030
Abstract: Genetic alterations in FGF/FGFR pathway are infrequent in gastrointestinal stromal tumors (GIST), with rare cases of quadruple wildtype GISTs harboring FGFR1 gene fusions and mutations. Additionally, FGF/FGFR overexpression was shown to promote drug resistance to… read more here.
Keywords: tacc2 fusion; fusion; kit; multidrug resistant ... See more keywords