Cost-effectiveness Analysis of Genetic Testing and Tailored First-Line Therapy for Patients With Metastatic Gastrointestinal Stromal Tumors
Sign Up to like & getrecommendations! Published in 2020 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2020.13565
Abstract: Key Points Question Is targeted gene testing cost-effective in patients with metastatic gastrointestinal stromal tumor? Findings This economic evaluation developed a Markov model to examine the cost-effectiveness of targeted gene testing with tailored imatinib dosing… read more here.
Keywords: metastatic gastrointestinal; patients metastatic; gastrointestinal stromal; testing tailored ... See more keywords
Nintedanib overcomes drug resistance from upregulation of FGFR signaling and imatinib-induced KIT mutations in gastrointestinal stromal tumors.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular oncology"
DOI: 10.1002/1878-0261.13199
Abstract: Drug resistance remains a major challenge in the clinical treatment of gastrointestinal stromal tumors (GISTs). While acquired on-target mutations of mast/stem cell growth factor receptor (KIT) kinase is the major resistance mechanism, activation of alternative… read more here.
Keywords: imatinib; stromal tumors; kit mutations; resistance ... See more keywords
Prediction of morbidity following cytoreductive surgery for metastatic gastrointestinal stromal tumour in patients on tyrosine kinase inhibitor therapy
Sign Up to like & getrecommendations! Published in 2018 at "British Journal of Surgery"
DOI: 10.1002/bjs.10774
Abstract: Although cytoreductive surgery has been shown to be beneficial in carefully selected patients with metastatic gastrointestinal stromal tumours (GISTs) treated with tyrosine kinase inhibitors (TKIs), factors predictive of postoperative morbidity have not been investigated previously. read more here.
Keywords: surgery; metastatic gastrointestinal; gastrointestinal stromal; cytoreductive surgery ... See more keywords
Relationship between R1 resection, tumour rupture and recurrence in resected gastrointestinal stromal tumour
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DOI: 10.1002/bjs.11027
Abstract: According to guidelines, adjuvant treatment or re‐excision should be considered after R1 resection of gastrointestinal stromal tumours (GISTs). However, the prognostic significance of R1 resection is uncertain and tumour rupture confounds its assessment. Here, the… read more here.
Keywords: relationship resection; tumour rupture; tumour; gastrointestinal stromal ... See more keywords
A correlation research of Ki67 index, CT features, and risk stratification in gastrointestinal stromal tumor
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Medicine"
DOI: 10.1002/cam4.1737
Abstract: Recurrence and metastasis are the most important factors affecting the quality of life and survival rate of patients with gastrointestinal stromal tumors (GISTs). Accurate preoperative determination of the malignant degree of GISTs and the development… read more here.
Keywords: correlation research; research ki67; ki67 index; gastrointestinal stromal ... See more keywords
Diagnosing gastrointestinal stromal tumors: The utility of fine‐needle aspiration cytology versus biopsy
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DOI: 10.1002/cam4.4630
Abstract: Gastrointestinal stromal tumors (GIST) are mesenchymal tumors in the intestinal tract originating from a precursor to the interstitial cells of Cajal, which plays a role in gastric motility. The preoperative diagnosis of GIST may be… read more here.
Keywords: diagnosing gastrointestinal; stromal tumors; utility fine; tumors utility ... See more keywords
Long‐term outcome of dasatinib first‐line treatment in gastrointestinal stromal tumor: A multicenter, 2‐stage phase 2 trial (Swiss Group for Clinical Cancer Research 56/07)
Sign Up to like & getrecommendations! Published in 2018 at "Cancer"
DOI: 10.1002/cncr.31234
Abstract: Tyrosine kinase inhibitors (TKIs) have improved the outcome of patients with gastrointestinal stromal tumors (GISTs), but most patients eventually develop resistance and progress. Dasatinib is a potent inhibitor of BCR‐ABL, KIT, and SRC family kinases… read more here.
Keywords: term outcome; long term; dasatinib; gastrointestinal stromal ... See more keywords
Ki‐67 index assessment on FNA specimens of gastrointestinal stromal tumor: Correlation with mitotic rate and potential predictive value for risk stratification
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Cytopathology"
DOI: 10.1002/cncy.22630
Abstract: Risk assessment of gastrointestinal stromal tumor (GIST) is challenging on cytology specimens. This study aims to determine whether Ki‐67 index evaluated on fine‐needle aspiration (FNA) specimens can correlate with the mitotic rate of GIST in… read more here.
Keywords: mitotic rate; stromal tumor; assessment; fna specimens ... See more keywords
FGFR2::TACC2 fusion as a novel KIT‐independent mechanism of targeted therapy failure in a multidrug‐resistant gastrointestinal stromal tumor
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DOI: 10.1002/gcc.23030
Abstract: Genetic alterations in FGF/FGFR pathway are infrequent in gastrointestinal stromal tumors (GIST), with rare cases of quadruple wildtype GISTs harboring FGFR1 gene fusions and mutations. Additionally, FGF/FGFR overexpression was shown to promote drug resistance to… read more here.
Keywords: tacc2 fusion; fusion; kit; multidrug resistant ... See more keywords
Agricultural exposure and risk of soft tissue sarcomas and gastrointestinal stromal sarcoma in the AGRIculture and CANcer (AGRICAN) cohort
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DOI: 10.1002/ijc.33936
Abstract: Sarcomas are a heterogeneous group of tumors whose incidence is nearly 5 per 100 000 inhabitants in Europe. Their causes are poorly understood, although occupational exposures (especially farming and pesticides) are suspected. The AGRICAN cohort is… read more here.
Keywords: agrican cohort; agricultural exposure; gastrointestinal stromal; sarcoma ... See more keywords
The role of neoadjuvant imatinib in gastrointestinal stromal tumor patients: 20 years of experience from a tertial referral center
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Cancer"
DOI: 10.1002/ijc.34052
Abstract: Surgery is the cornerstone of gastrointestinal stromal tumor (GIST) treatment, and adjuvant therapy with imatinib has improved survival for high‐risk tumors. The use of imatinib preoperatively has been increasing, but efficacy and impact on patient… read more here.
Keywords: stromal tumor; surgery; tumor; neoadjuvant imatinib ... See more keywords