The bidirectional interaction of the gut microbiome and the innate immune system: Implications for chemotherapy‐induced gastrointestinal toxicity
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Cancer"
DOI: 10.1002/ijc.31836
Abstract: Chemotherapy‐induced gastrointestinal toxicity (CIGT) occurs in up to 80% of all patients undergoing cancer treatment, and leads to symptoms such as diarrhoea, abdominal bleeding and pain. There is currently limited understanding of how to predict… read more here.
Keywords: gastrointestinal toxicity; toxicity; immune system; gut microbiome ... See more keywords
Analysis of Gastrointestinal Toxicity in Patients Receiving Proton Beam Therapy for Prostate Cancer: A Single-Institution Experience
Sign Up to like & getrecommendations! Published in 2019 at "Advances in Radiation Oncology"
DOI: 10.1016/j.adro.2018.08.002
Abstract: Purpose We characterized both physician- and patient-reported rates of gastrointestinal (GI) toxicity in patients treated with proton beam therapy (PBT) at our institution for prostate adenocarcinoma and identified factors associated with toxicity. Methods and materials… read more here.
Keywords: prostate; gastrointestinal toxicity; toxicity patients; toxicity ... See more keywords
Morbidity following image-guided brachytherapy for cervical cancer: Patient and treatment related factors.
Sign Up to like & getrecommendations! Published in 2021 at "Brachytherapy"
DOI: 10.1016/j.brachy.2021.05.014
Abstract: PURPOSE This retrospective study aims to assess factors associated with the occurrence of toxicity after brachytherapy (BT), as boost after external beam radiotherapy (EBRT) for treatment of invasive cervix carcinoma. METHODS AND MATERIALS All consecutive… read more here.
Keywords: gastrointestinal toxicity; volume; treatment; toxicity ... See more keywords
NSAIDs, gastrointestinal toxicity and Inflammatory Bowel Disease.
Sign Up to like & getrecommendations! Published in 2021 at "Gastroenterologia y hepatologia"
DOI: 10.1016/j.gastrohep.2021.06.003
Abstract: Non-steroidal antiinflammatory drugs (NSAIDs) are currently one of the most widely used drugs. The use of NSAIDs is associated with gastrointestinal toxicity, affecting both upper gastrointestinal tract (peptic ulcer disease) and lower gastrointestinal tract (NSAID… read more here.
Keywords: toxicity; gastrointestinal toxicity; inflammatory bowel; bowel disease ... See more keywords
The Efficacy of Dietary Fiber in Managing Gastrointestinal Toxicity Symptoms in Patients with Gynecologic Cancers undergoing Pelvic Radiotherapy: A Systematic Review.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the Academy of Nutrition and Dietetics"
DOI: 10.1016/j.jand.2020.08.077
Abstract: BACKGROUND Pelvic radiotherapy is a common part of treatment used in gynecologic malignancies. The side effects associated with treatment, such as gastrointestinal toxicity, can be acute and chronic. Previous studies have provided little clarity in… read more here.
Keywords: gastrointestinal toxicity; systematic review; toxicity; fiber ... See more keywords
Clinical pattern and prevalence of upper gastrointestinal toxicity in patients abusing ketamine
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Digestive Diseases"
DOI: 10.1111/1751-2980.12512
Abstract: Evaluations of upper gastrointestinal toxicity from ketamine abuse are uncommon. This study investigated the clinical pattern of upper gastrointestinal symptoms in patients inhaling ketamine. read more here.
Keywords: clinical pattern; upper gastrointestinal; gastrointestinal toxicity; pattern prevalence ... See more keywords
Opioid‐induced microbial dysbiosis disrupts irinotecan (CPT‐11) metabolism and increases gastrointestinal toxicity in a murine model
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Pharmacology"
DOI: 10.1111/bph.16020
Abstract: Opioids are commonly used for the management of cancer‐associated pain and chemotherapy‐induced diarrhoea. The chemotherapeutic irinotecan (CPT‐11) causes severe gastrointestinal (GI) toxicity due to deconjugation of inactive metabolite SN‐38 glucuronide (SN‐38G) by bacterial β‐glucuronidases to… read more here.
Keywords: microbial dysbiosis; gastrointestinal toxicity; opioid induced; toxicity ... See more keywords
Orally Administered Probiotics in the Prevention of Chemotherapy (± Radiotherapy)-Induced Gastrointestinal Toxicity: A Systematic Review With Meta-Analysis of Randomized Trials
Sign Up to like & getrecommendations! Published in 2022 at "Integrative Cancer Therapies"
DOI: 10.1177/15347354221144309
Abstract: Background: Chemoradiotherapy-induced gastrointestinal toxicity may lead to a significant impairment of the oncological patient’s quality of life, as well as to reduced adherence to the treatment, which may have a negative impact on survival and… read more here.
Keywords: induced gastrointestinal; radiotherapy induced; chemotherapy radiotherapy; gastrointestinal toxicity ... See more keywords
SEVERE GASTROINTESTINAL TOXICITY SECONDARY TO FLUOROPYRIMIDINES: ACUTE ESOPHAGEAL NECROSIS ASSOCIATED EXTENSIVE DUODENAL MUCOSITIS.
Sign Up to like & getrecommendations! Published in 2020 at "Revista Espanola De Enfermedades Digestivas"
DOI: 10.17235/reed.2020.7500/2020
Abstract: A 68-year-old male with stage IV sigmoid adenocarcinoma (liver metastases). KRAS and BRAF wild type. No other medical-surgical history of interest. In first line treatment with 5-Fluoracil, oxaliplatin and cetuximab. One week after the administration… read more here.
Keywords: esophageal necrosis; mucositis; severe gastrointestinal; gastrointestinal toxicity ... See more keywords
Dose evaluations of organs at risk and predictions of gastrointestinal toxicity after re-irradiation with stereotactic body radiation therapy for pancreatic cancer by deformable image registration
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.1021058
Abstract: Purpose Re-irradiation of locally recurrent pancreatic cancer may be an optimal choice as a local ablative therapy. However, dose constraints of organs at risk (OARs) predictive of severe toxicity remain unknown. Therefore, we aim to… read more here.
Keywords: dose constraints; gastrointestinal toxicity; pancreatic cancer; toxicity ... See more keywords
Shengjiang Xiexin Decoction Alters Pharmacokinetics of Irinotecan by Regulating Metabolic Enzymes and Transporters: A Multi-Target Therapy for Alleviating the Gastrointestinal Toxicity
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2017.00769
Abstract: Shengjiang Xiexin decoction (SXD), a classic traditional Chinese medical formula chronicled in Shang Han Lun, is used in modern clinical practice to decrease gastrointestinal toxicity induced by the chemotherapeutic drug irinotecan (CPT-11). In this study,… read more here.
Keywords: shengjiang xiexin; gastrointestinal toxicity; cpt; sxd ... See more keywords