Deconstructing gastrulation at single-cell resolution
Sign Up to like & getrecommendations! Published in 2022 at "Current Biology"
DOI: 10.1016/j.cub.2022.02.059
Abstract: Gastrulation movements in all animal embryos start with regulated deformations of patterned epithelial sheets, which are driven by cell divisions, cell shape changes, and cell intercalations. Each of these behaviors has been associated with distinct… read more here.
Keywords: gastrulation single; deconstructing gastrulation; gastrulation; cell ... See more keywords
Cells under Tension Drive Gastrulation.
Sign Up to like & getrecommendations! Published in 2020 at "Developmental cell"
DOI: 10.1016/j.devcel.2020.11.023
Abstract: In this issue of Developmental Cell, Muncie et al. describe the generation of gastrulation-like foci of cells within micropatterned colonies of pluripotent stem cells. This demonstration of mechanosensitive β-catenin/Wnt-dependent specification of cell fate during gastrulation illustrates… read more here.
Keywords: cell; tension drive; cells tension; gastrulation ... See more keywords
Use of Drosophila melanogaster to perform systemic assessment of cytotoxic effects exerted by ingested silver nanoparticles
Sign Up to like & getrecommendations! Published in 2017 at "Mechanisms of Development"
DOI: 10.1016/j.mod.2017.04.270
Abstract: the top half being extraembryonic ectoderm-trophoblast (ExE), the bottom epiblast. The ExE secretes proteases (Furin), which diffuse into the epiblast rim to activate Nodal, resulting in gastrulation. In most other mammals, the pregastrulation embryo resembles… read more here.
Keywords: disc shaped; melanogaster perform; drosophila melanogaster; use drosophila ... See more keywords
The extraordinary biology and development of marsupial frogs (Hemiphractidae) in comparison with fish, mammals, birds, amphibians and other animals
Sign Up to like & getrecommendations! Published in 2018 at "Mechanisms of Development"
DOI: 10.1016/j.mod.2017.12.002
Abstract: The study of oogenesis and early development of frogs belonging to the family Hemiphractidae provide important comparison to the aquatic development of other frogs, such as Xenopus laevis, because reproduction on land characterizes the Hemiphractidae.… read more here.
Keywords: extraordinary biology; frog; biology; gastrulation ... See more keywords
Retinoic acid prevents synaptic deficiencies induced by alcohol exposure during gastrulation in zebrafish embryos
Sign Up to like & getrecommendations! Published in 2017 at "Neurotoxicology"
DOI: 10.1016/j.neuro.2017.05.011
Abstract: HIGHLIGHTSZebrafish embryos were exposed to ethanol or a combination of ethanol and Retinoic Acid during gastrulation.Exposure to ethanol led to a reduction in excitatory synaptic activity associated with Mauthner cells.Co‐treatment with Retinoic Acid (1 nM)… read more here.
Keywords: embryos; treatment; exposure; retinoic acid ... See more keywords
Netrin expressed by the ventral ectoderm lineage guides mesoderm migration in epibolic gastrulation of the leech.
Sign Up to like & getrecommendations! Published in 2020 at "Developmental biology"
DOI: 10.1016/j.ydbio.2020.04.002
Abstract: Netrin is a remarkably conserved midline landmark, serving as a chemotactic factor that organizes the bilateral neural architecture in the post-gastrula bilaterian embryos. Netrin signal also guides cell migration in many other neural and non-neural… read more here.
Keywords: lineage; netrin expressed; migration; gastrulation leech ... See more keywords
Leucine repeat adaptor protein 1 interacts with Dishevelled to regulate gastrulation cell movements in zebrafish
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-01552-x
Abstract: Gastrulation is a fundamental morphogenetic event that requires polarised cell behaviours for coordinated asymmetric cell movements. Wnt/PCP signalling plays a critical role in this process. Dishevelled is an important conserved scaffold protein that relays Wnt/PCP… read more here.
Keywords: cell movements; interacts dishevelled; gastrulation; cell ... See more keywords
Regionalized tissue fluidization is required for epithelial gap closure during insect gastrulation
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-19356-x
Abstract: Many animal embryos pull and close an epithelial sheet around the ellipsoidal egg surface during a gastrulation process known as epiboly. The ovoidal geometry dictates that the epithelial sheet first expands and subsequently compacts. Moreover,… read more here.
Keywords: closure; tissue; tissue fluidization; regionalized tissue ... See more keywords
Epigenetic regulator function through mouse gastrulation
Sign Up to like & getrecommendations! Published in 2020 at "Nature"
DOI: 10.1038/s41586-020-2552-x
Abstract: During ontogeny, proliferating cells become restricted in their fate through the combined action of cell-type-specific transcription factors and ubiquitous epigenetic machinery, which recognizes universally available histone residues or nucleotides in a context-dependent manner 1 ,… read more here.
Keywords: single cell; regulator function; epigenetic regulator; gastrulation ... See more keywords
Embryonic ethanol exposure alters expression of sox2 and other early transcripts in zebrafish, producing gastrulation defects
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-59043-x
Abstract: Ethanol exposure during prenatal development causes fetal alcohol spectrum disorder (FASD), the most frequent preventable birth defect and neurodevelopmental disability syndrome. The molecular targets of ethanol toxicity during development are poorly understood. Developmental stages surrounding… read more here.
Keywords: ethanol exposure; early transcripts; dysregulated genes; ethanol ... See more keywords
Mammalian gastrulation: signalling activity and transcriptional regulation of cell lineage differentiation and germ layer formation.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical Society transactions"
DOI: 10.1042/bst20220256
Abstract: The interplay of signalling input and downstream transcriptional activity is the key molecular attribute driving the differentiation of germ layer tissue and the specification of cell lineages within each germ layer during gastrulation. This review… read more here.
Keywords: layer; gastrulation; activity; germ layer ... See more keywords