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   Articles with "gata1" as a keyword



A Distinct Mechanism of RNA Recognition by the Transcription Factor GATA1.

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recommendations! Published in 2025 at "Biochemistry"

DOI: 10.1021/acs.biochem.4c00818

Abstract: Several human transcription factors (TFs) have been reported to directly bind RNA through noncanonical RNA-binding domains; however, most of these TFs remain to be further validated as bona fide RNA-binding proteins (RBPs). Our systematic analysis… read more here.

Keywords: rna; gata1; rna binding; dna ... See more keywords
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Post-induction MRD by FCM and GATA1-PCR are significant prognostic factors for myeloid leukemia of Down syndrome

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recommendations! Published in 2021 at "Leukemia"

DOI: 10.1038/s41375-021-01157-w

Abstract: Myeloid leukemia of Down syndrome (ML-DS) is associated with good response to chemotherapy, resulting in favorable outcomes. However, no universal prognostic factors have been identified to date. To clarify a subgroup with high risk of… read more here.

Keywords: mrd; gata1; prognostic factors; myeloid leukemia ... See more keywords
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GATA1 insufficiencies in primary myelofibrosis and other hematopoietic disorders: consequences for therapy

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recommendations! Published in 2018 at "Expert Review of Hematology"

DOI: 10.1080/17474086.2018.1436965

Abstract: ABSTRACT Introduction: GATA1, the founding member of a family of transcription factors, plays important roles in the development of hematopoietic cells of several lineages. Although loss of GATA1 has been known to impair hematopoiesis in… read more here.

Keywords: hematopoietic disorders; gata1; primary myelofibrosis; gata1 insufficiencies ... See more keywords

GATA1 Is a Sensitive and Specific Nuclear Marker for Erythroid and Megakaryocytic Lineages

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recommendations! Published in 2017 at "American Journal of Clinical Pathology"

DOI: 10.1093/ajcp/aqx018

Abstract: Objectives GATA binding factor 1 (GATA1) is a transcription factor essential for erythromegakaryocytic differentiation. Given its function in lineage specification, we sought to evaluate the immunohistochemical profile of GATA1 in normal marrow and acute leukemia… read more here.

Keywords: gata1; megakaryocytic lineages; erythroid megakaryocytic; marker ... See more keywords

Diamond‐Blackfan anaemia caused by a de novo initiation codon mutation resulting in a shorter isoform of GATA1

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recommendations! Published in 2022 at "Clinical Genetics"

DOI: 10.1111/cge.14218

Abstract: Diamond‐Blackfan anaemia (DBA) is an inherited marrow failure disorder characterised by selective erythroid aplasia. Herein, we reported a case of DBA caused by a novel GATA1 gene mutation. The proband manifested normocytic normochromic anaemia, while… read more here.

Keywords: diamond blackfan; blackfan anaemia; initiation codon; gata1 ... See more keywords

Autopsy case of a stillbirth with transient abnormal myelopoiesis associated with Down syndrome: Immunohistochemical demonstration of GATA1 mutation in placental tissues

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recommendations! Published in 2024 at "Pathology International"

DOI: 10.1111/pin.13497

Abstract: Transient abnormal myelopoiesis (TAM) in neonates with Down syndrome (DS) exhibits hematological features that are indistinguishable from those of acute megakaryoblastic leukemia. However, TAM typically resolves spontaneously within several months postnatally. Some patients with TAM,… read more here.

Keywords: placental tissues; gata1; abnormal myelopoiesis; transient abnormal ... See more keywords

Lost in translation: RP and GATA1 mutations in DBA.

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recommendations! Published in 2017 at "Blood"

DOI: 10.1182/blood-2017-04-778969

Abstract: In this issue of Blood, O’Brien and colleagues1 demonstrate impaired growth of circulating red-cell progenitor cells ex vivo from patients with Diamond-Blackfan anemia (DBA) with ribosomal protein (RP) or GATA1 mutations. Distinct transcriptional profiles in… read more here.

Keywords: translation gata1; lost translation; gata1; gata1 mutations ... See more keywords

Modeling the Initiation and Evolution of Down Syndrome Associated Leukemia Using CRISPR/Cas9

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recommendations! Published in 2018 at "Blood"

DOI: 10.1182/blood-2018-99-110363

Abstract: Children with Down syndrome, also known as trisomy 21, have a significantly increased risk of childhood acute leukemia in the first few years after birth. The acute leukemia phase is preceded with a transient pre-leukemia… read more here.

Keywords: gata1; crispr cas9; isoform; differentiation ... See more keywords

Infant Acute Myeloid Leukemia with t(X;6)(p11;q23)/MYB-GATA1- a First Female Case in the Entity

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recommendations! Published in 2020 at "Blood"

DOI: 10.1182/blood-2020-140218

Abstract: Introduction T(X;6)(p11;q23) is a rear but recurrent chromosomal translocation in infant acute myeloid leukemia (AML). It leads to the formation ofMYB-GATA1fusion gene that interferes with granulocyte lineage commitment thus causing AML preliminary with basophilic phenotype.… read more here.

Keywords: patient; myb gata1; p11 q23; gata1 ... See more keywords

An Essential Role for the N-Terminus of GATA1 in Metabolic Regulation during Erythropoiesis

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recommendations! Published in 2024 at "Blood"

DOI: 10.1182/blood-2024-210865

Abstract: Several lines of evidence confirm that the N-terminus of GATA1 plays a pivotal role in normal erythroid differentiation, including the phenotype of patients with N-terminal truncations, the inability of GATA1 N-terminal deleted iPSCs to generate… read more here.

Keywords: role; gata1; regulation; hudep cells ... See more keywords

A novel role for Friend of GATA1 (FOG-1) in regulating cholesterol transport in murine erythropoiesis

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recommendations! Published in 2025 at "PLOS Genetics"

DOI: 10.1371/journal.pgen.1011617

Abstract: Friend of GATA1 (FOG-1) is an essential transcriptional co-factor of the master erythroid transcription factor GATA1. The knockout of the Zfpm1 gene, coding for FOG-1, results in early embryonic lethality due to anemia in mice,… read more here.

Keywords: zfpm1; cholesterol transport; knockout; gata1 ... See more keywords