Post-induction MRD by FCM and GATA1-PCR are significant prognostic factors for myeloid leukemia of Down syndrome
Sign Up to like & getrecommendations! Published in 2021 at "Leukemia"
DOI: 10.1038/s41375-021-01157-w
Abstract: Myeloid leukemia of Down syndrome (ML-DS) is associated with good response to chemotherapy, resulting in favorable outcomes. However, no universal prognostic factors have been identified to date. To clarify a subgroup with high risk of… read more here.
Keywords: mrd; gata1; prognostic factors; myeloid leukemia ... See more keywords
GATA1 insufficiencies in primary myelofibrosis and other hematopoietic disorders: consequences for therapy
Sign Up to like & getrecommendations! Published in 2018 at "Expert Review of Hematology"
DOI: 10.1080/17474086.2018.1436965
Abstract: ABSTRACT Introduction: GATA1, the founding member of a family of transcription factors, plays important roles in the development of hematopoietic cells of several lineages. Although loss of GATA1 has been known to impair hematopoiesis in… read more here.
Keywords: hematopoietic disorders; gata1; primary myelofibrosis; gata1 insufficiencies ... See more keywords
GATA1 Is a Sensitive and Specific Nuclear Marker for Erythroid and Megakaryocytic Lineages
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DOI: 10.1093/ajcp/aqx018
Abstract: Objectives GATA binding factor 1 (GATA1) is a transcription factor essential for erythromegakaryocytic differentiation. Given its function in lineage specification, we sought to evaluate the immunohistochemical profile of GATA1 in normal marrow and acute leukemia… read more here.
Keywords: gata1; megakaryocytic lineages; erythroid megakaryocytic; marker ... See more keywords
Diamond‐Blackfan anaemia caused by a de novo initiation codon mutation resulting in a shorter isoform of GATA1
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DOI: 10.1111/cge.14218
Abstract: Diamond‐Blackfan anaemia (DBA) is an inherited marrow failure disorder characterised by selective erythroid aplasia. Herein, we reported a case of DBA caused by a novel GATA1 gene mutation. The proband manifested normocytic normochromic anaemia, while… read more here.
Keywords: diamond blackfan; blackfan anaemia; initiation codon; gata1 ... See more keywords
Lost in translation: RP and GATA1 mutations in DBA.
Sign Up to like & getrecommendations! Published in 2017 at "Blood"
DOI: 10.1182/blood-2017-04-778969
Abstract: In this issue of Blood, O’Brien and colleagues1 demonstrate impaired growth of circulating red-cell progenitor cells ex vivo from patients with Diamond-Blackfan anemia (DBA) with ribosomal protein (RP) or GATA1 mutations. Distinct transcriptional profiles in… read more here.
Keywords: translation gata1; lost translation; gata1; gata1 mutations ... See more keywords
Modeling the Initiation and Evolution of Down Syndrome Associated Leukemia Using CRISPR/Cas9
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DOI: 10.1182/blood-2018-99-110363
Abstract: Children with Down syndrome, also known as trisomy 21, have a significantly increased risk of childhood acute leukemia in the first few years after birth. The acute leukemia phase is preceded with a transient pre-leukemia… read more here.
Keywords: gata1; crispr cas9; isoform; differentiation ... See more keywords
Infant Acute Myeloid Leukemia with t(X;6)(p11;q23)/MYB-GATA1- a First Female Case in the Entity
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DOI: 10.1182/blood-2020-140218
Abstract: Introduction T(X;6)(p11;q23) is a rear but recurrent chromosomal translocation in infant acute myeloid leukemia (AML). It leads to the formation ofMYB-GATA1fusion gene that interferes with granulocyte lineage commitment thus causing AML preliminary with basophilic phenotype.… read more here.
Keywords: patient; myb gata1; p11 q23; gata1 ... See more keywords
PAK5 is a potential target in myelodysplastic syndrome through interacting with LMO2 and GATA1.
Sign Up to like & getrecommendations! Published in 2022 at "Cellular and molecular biology"
DOI: 10.14715/cmb/2022.68.9.12
Abstract: Myelodysplastic syndrome (MDS) is a neoplastic heterogeneous and pre-leukemic disease with poor clinical outcome due to the failure of current chemotherapeutic strategies to target leukemic stem cells. Recently, we find that p21-activated kinase 5 (PAK5)… read more here.
Keywords: pak5 potential; lmo2 gata1; gata1; pak5 ... See more keywords
Transcription factor GATA1 represses oxidized-low density lipoprotein-induced pyroptosis of human coronary artery endothelial cells.
Sign Up to like & getrecommendations! Published in 2022 at "Clinical hemorheology and microcirculation"
DOI: 10.3233/ch-221536
Abstract: BACKGROUND Atherosclerosis (AS) is defined as a chronic inflammatory disorder underly the pathogenesis of cardiovascular diseases (CVDs). Endothelial pyroptosis is associated with AS-like diseases and other CVDs. OBJECTIVE This work was designed to expound on… read more here.
Keywords: ror; transcription; pyroptosis; pyroptosis human ... See more keywords
GATA-1 Defects in Diamond–Blackfan Anemia: Phenotypic Characterization Points to a Specific Subset of Disease
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DOI: 10.3390/genes13030447
Abstract: Diamond–Blackfan anemia (DBA) is one of the inherited bone marrow failure syndromes marked by erythroid hypoplasia. Underlying variants in ribosomal protein (RP) genes account for 80% of cases, thereby classifying DBA as a ribosomopathy. In… read more here.
Keywords: blackfan anemia; diamond blackfan; dba; gata1 ... See more keywords