GATA1 pathogenic variants disrupt MYH10 silencing during megakaryopoiesis
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DOI: 10.1111/jth.15412
Abstract: GATA1 is an essential transcription factor for both polyploidization and megakaryocyte (MK) differentiation. The polyploidization defect observed in GATA1 variant carriers is not well understood. read more here.
Keywords: disrupt myh10; myh10 silencing; gata1 pathogenic; pathogenic variants ... See more keywords