Antidepressant‐like effects of geniposide in chronic unpredictable mild stress‐induced mice by regulating the circ_0008405/miR‐25‐3p/Gata2 and Oip5os1/miR‐25‐3p/Gata2 networks
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7702
Abstract: Evidence exists suggesting the anti‐depressive activities of geniposide (GP), a major compound in Gardenia jasminoides Ellis. Accordingly, the present study attempts to explore the anti‐depressive mechanism of GP in chronic unpredictable mild stress (CUMS)‐induced depression‐like… read more here.
Keywords: mir gata2; oip5os1; gata2; mir ... See more keywords
The ancient role for GATA2/3 transcription factor homolog in the hemocyte production of oyster
Sign Up to like & getrecommendations! Published in 2018 at "Developmental and Comparative Immunology"
DOI: 10.1016/j.dci.2018.01.001
Abstract: ABSTRACT Hemocytes, the cellular component of invertebrate hemolymph, are essential for invertebrate immunity, but the hematopoiesis and regulation mechanism are still largely unknown. In the present study, a conserved hematopoietic transcription factor Cg‐GATA2/3 was identified… read more here.
Keywords: transcription factor; oyster; hemocyte; gata2 ... See more keywords
Effects of in vivo deletion of GATA2 in bone marrow stromal cells.
Sign Up to like & getrecommendations! Published in 2017 at "Experimental hematology"
DOI: 10.1016/j.exphem.2017.08.004
Abstract: The bone marrow (BM) microenvironment comprises multiple stem cell niches derived from BM mesenchymal stem cells (MSCs). Previous in vitro analyses have suggested that transcription factor GATA2 plays an important role in adipocyte differentiation of… read more here.
Keywords: stromal cells; gata2; bone; mice ... See more keywords
3098 – THE ROLE OF GATA2 IN HSC GENERATION THROUGH ENDOTHELIAL-TO-HEMATOPOIETIC TRANSITION
Sign Up to like & getrecommendations! Published in 2020 at "Experimental Hematology"
DOI: 10.1016/j.exphem.2020.09.111
Abstract: GATA2 is the most frequently mutated gene in childhood AML. These patients have germline mutations in one allele of GATA2 and have a high predisposition for MDS/AML. Also, in mouse, Gata2 is required for embryonic… read more here.
Keywords: endothelial hematopoietic; gata2 haploinsufficiency; hsc generation; gata2 ... See more keywords
Breaking the spatial constraint between neighboring zinc fingers: a new germline mutation in GATA2 deficiency syndrome
Sign Up to like & getrecommendations! Published in 2020 at "Leukemia"
DOI: 10.1038/s41375-020-0820-2
Abstract: GATA2 deficiency syndrome is an autosomal dominant disorder caused by germline mutations in the GATA2 gene, which encodes a transcription factor with two zinc fingers that is essential for hematopoiesis. There are four classes of… read more here.
Keywords: zinc fingers; gata2 deficiency; gata2; mutation ... See more keywords
GATA2 zinc finger 1 mutations are associated with distinct clinico-biological features and outcomes different from GATA2 zinc finger 2 mutations in adult acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2018 at "Blood Cancer Journal"
DOI: 10.1038/s41408-018-0123-2
Abstract: Mutations of the GATA binding protein 2 (GATA2) gene in myeloid malignancies usually cluster in the zinc finger 1 (ZF1) and the ZF2 domains. Mutations in different locations of GATA2 may have distinct impact on… read more here.
Keywords: zinc finger; finger mutations; gata2; gata2 zinc ... See more keywords
Down-regulation of CCR7 via AKT pathway and GATA2 inactivation suppressed trophoblast migration and invasion in recurrent spontaneous abortion
Sign Up to like & getrecommendations! Published in 2019 at "Biology of Reproduction"
DOI: 10.1093/biolre/ioz172
Abstract: Abstract The underlying mechanism of the chemokine-C receptor 7 (CCR7) that leads to aberrant trophoblast migration and invasion in recurrent spontaneous abortion (RSA) remains unknown. CCR7 is considered crucial for migration and invasion and has… read more here.
Keywords: trophoblast migration; migration invasion; ccr7; gata2 ... See more keywords
Pediatric Donor Cell Acute Lymphoblastic Leukemia Following Bone Marrow Transplant for GATA2 Mutation
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Pediatric Hematology/Oncology"
DOI: 10.1097/mph.0000000000002437
Abstract: Donor cell leukemia is a rare complication following hematopoietic stem cell transplant (HSCT). There are currently few reports in children and only rare, reported cases of donor-derived myelodysplastic syndrome/acute myeloid leukemia in patients with an… read more here.
Keywords: cell; donor cell; leukemia; gata2 ... See more keywords
Prevalence of germline GATA2 and SAMD9/9L variants in paediatric haematological disorders with monosomy 7
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Haematology"
DOI: 10.1111/bjh.17006
Abstract: Monosomy 7 (−7) occurs in various types of paediatric myeloid disorders and has a poor prognosis. Recent studies have demonstrated that patients with germline gain‐of‐function SAMD9/9L variants and loss‐of‐function GATA2 variants are prone to developing… read more here.
Keywords: samd9 variants; gata2; gata2 samd9; germline ... See more keywords
The independent prognostic impact of the GATA2 pioneering factor is restricted to ERG-negative prostate cancer
Sign Up to like & getrecommendations! Published in 2019 at "Tumor Biology"
DOI: 10.1177/1010428318824815
Abstract: GATA2 is a pioneering transcription factor governing androgen receptor expression and signaling in prostate cells. To understand the prognostic potential of GATA2 assessment in prostate cancer, we analyzed nuclear GATA2 expression on an annotated tissue… read more here.
Keywords: erg negative; expression; gata2; prostate cancer ... See more keywords
GATA2 in Bone Marrow Failure
Sign Up to like & getrecommendations! Published in 2017 at "Blood"
DOI: 10.1182/blood.v130.suppl_1.sci-23.sci-23
Abstract: Abstract The syndrome now known as GATA2 haploinsufficiency had been published at least since the 1970s under different clinical guises. With the identification of the gene in 2011, GATA2 deficiency became the overarching diagnosis for… read more here.
Keywords: gata2; gata2 deficiency; bone marrow;