Possible mechanism of GATA4 inhibiting myocardin activity during cardiac hypertrophy
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28178
Abstract: Myocardin is an important factor that regulates cardiac hypertrophy, and its activity can be regulated by GATA4. However, the molecular mechanism of the above process remains unclear. This paper presents three kinds of possible molecular… read more here.
Keywords: cardiac hypertrophy; gata4 inhibiting; myocardin; gata4 ... See more keywords
GATA4 represses RANKL in osteoblasts via multiple long-range enhancers to regulate osteoclast differentiation.
Sign Up to like & getrecommendations! Published in 2018 at "Bone"
DOI: 10.1016/j.bone.2018.07.014
Abstract: GATA4 is a transcription factor that is responsible for tissue-specific gene regulation in many tissues, and more recent studies showed that it is necessary for osteoblast differentiation. Previously, we showed that in vivo deletion of… read more here.
Keywords: gata4 represses; rankl osteoblasts; bone; represses rankl ... See more keywords
Effects of PM2.5 exposure in utero on heart injury, histone acetylation and GATA4 expression in offspring mice.
Sign Up to like & getrecommendations! Published in 2020 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2020.127133
Abstract: Atmospheric fine particulate matter exposure (PM2.5) can increase the incidence and mortality of heart disease, and raise the risk of fetal congenital heart defect, which have recently drawn much attention. In this study, C57BL/6 mice… read more here.
Keywords: heart; offspring mice; exposure; gata4 ... See more keywords
GATA4 is a transcriptional regulator of R-spondin1 in Japanese flounder (Paralichthys olivaceus).
Sign Up to like & getrecommendations! Published in 2018 at "Gene"
DOI: 10.1016/j.gene.2018.01.041
Abstract: GATA4 is a well-known transcription factor of the GATA family implicated in regulation of sex determination and gonadal development in mammals. In this study, we cloned the full-length cDNA of Paralichthys olivaceus gata4 (Po-gata4). Phylogenetic,… read more here.
Keywords: olivaceus; paralichthys olivaceus; gata4; flounder ... See more keywords
Genome-wide transcriptomics analysis identifies sox7 and sox18 as specifically regulated by gata4 in cardiomyogenesis
Sign Up to like & getrecommendations! Published in 2018 at "Developmental Biology"
DOI: 10.1016/j.ydbio.2017.11.017
Abstract: The transcription factors GATA4, GATA5 and GATA6 are important regulators of heart muscle differentiation (cardiomyogenesis), which function in a partially redundant manner. We identified genes specifically regulated by individual cardiogenic GATA factors in a genome-wide… read more here.
Keywords: genome wide; cardiomyogenesis; sox7 sox18; wide transcriptomics ... See more keywords
A GATA4-regulated secretory program suppresses tumors through recruitment of cytotoxic CD8 T cells
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-021-27731-5
Abstract: The GATA4 transcription factor acts as a master regulator of development of multiple tissues. GATA4 also acts in a distinct capacity to control a stress-inducible pro-inflammatory secretory program that is associated with senescence, a potent… read more here.
Keywords: tumor; secretory program; cd8 cells; cytotoxic cd8 ... See more keywords
The nuclear receptor ERR cooperates with the cardiogenic factor GATA4 to orchestrate cardiomyocyte maturation.
Sign Up to like & getrecommendations! Published in 2022 at "Nature communications"
DOI: 10.1038/s41467-022-29733-3
Abstract: Estrogen-related receptors (ERR) α and γ were shown recently to serve as regulators of cardiac maturation, yet the underlying mechanisms have not been delineated. Herein, we find that ERR signaling is necessary for induction of… read more here.
Keywords: gata4; factor gata4; maturation; err ... See more keywords
Role of GATA binding protein 4 (GATA4) in the regulation of tooth development via GNAI3
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-01689-1
Abstract: Transcription factor GATA4 regulates cardiac and osteoblast differentiation. However, its role in tooth development is not clear. Therefore, we generated Wnt1-Cre;GATA4fl/fl mice, with conditional inactivation of the GATA4 gene in the dental papilla mesenchymal cells.… read more here.
Keywords: protein; root; tooth development; role ... See more keywords
Appropriate Exogenous Expression Stoichiometry of GATA4 as an Important Factor for Cardiac Reprogramming of Human Dermal Fibroblasts.
Sign Up to like & getrecommendations! Published in 2022 at "Cellular reprogramming"
DOI: 10.1089/cell.2022.0014
Abstract: Reprogramming of human dermal fibroblasts (HDFs) into induced cardiomyocyte-like cells (iCMs) represents a promising strategy for human cardiac regeneration. Different cocktails of cardiac transcription factors can convert HDFs into iCMs, although with low efficiency and… read more here.
Keywords: dermal fibroblasts; gata4; stoichiometry; expression ... See more keywords
Deacetylase-independent function of SIRT6 couples GATA4 transcription factor and epigenetic activation against cardiomyocyte apoptosis
Sign Up to like & getrecommendations! Published in 2020 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaa214
Abstract: Abstract SIRT6 deacetylase activity improves stress resistance via gene silencing and genome maintenance. Here, we reveal a deacetylase-independent function of SIRT6, which promotes anti-apoptotic gene expression via the transcription factor GATA4. SIRT6 recruits TIP60 acetyltransferase… read more here.
Keywords: deacetylase; independent function; function sirt6; gata4 ... See more keywords
The zinc finger protein GATA4 induces mesenchymal‐to‐epithelial transition and cellular senescence through the nuclear factor‐κB pathway in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Gastroenterology and Hepatology"
DOI: 10.1111/jgh.14684
Abstract: The high mortality and poor prognosis of hepatocellular carcinoma (HCC) have raised the public attention. Gene therapy is considered as a promising treatment option for cancer; thus, finding a new therapeutic target for HCC is… read more here.
Keywords: hepatocellular carcinoma; zinc finger; protein gata4; finger protein ... See more keywords