The status of MAPK cascades contributes to the induction and activation of Gata4 and Nkx2.5 during the stepwise process of cardiac differentiation.
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DOI: 10.1016/j.cellsig.2018.11.019
Abstract: Cardiac differentiation in vitro is a complex, stepwise process that is rigidly governed by a subset of transcription factors and signaling cascades. In this study, we investigated the cooperation of cardiac-specific transcription factors Gata4 and… read more here.
Keywords: mapk; differentiation; activation; stage ... See more keywords
Discovery of Small Molecules Targeting the Synergy of Cardiac Transcription Factors GATA4 and NKX2-5.
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DOI: 10.1021/acs.jmedchem.7b00816
Abstract: Transcription factors are pivotal regulators of gene transcription, and many diseases are associated with the deregulation of transcriptional networks. In the heart, the transcription factors GATA4 and NKX2-5 are required for cardiogenesis. GATA4 and NKX2-5… read more here.
Keywords: transcription; factors gata4; small molecules; transcription factors ... See more keywords
Synthesis, Identification, and Structure–Activity Relationship Analysis of GATA4 and NKX2-5 Protein–Protein Interaction Modulators
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DOI: 10.1021/acs.jmedchem.9b01086
Abstract: Transcription factors GATA4 and NKX2-5 directly interact and synergistically activate several cardiac genes and stretch-induced cardiomyocyte hypertrophy. Previously, we identified phenylisoxazole carboxamide 1 as a hit compound, which inhibited the GATA4–NKX2-5 transcriptional synergy. Here, the… read more here.
Keywords: protein; analysis; gata4 nkx2; structure activity ... See more keywords