β-catenin coordinates with Jup and the TCF1/GATA6 axis to regulate human embryonic stem cell fate.
Sign Up to like & getrecommendations! Published in 2017 at "Developmental biology"
DOI: 10.1016/j.ydbio.2017.09.004
Abstract: β-catenin-mediated signaling has been extensively studied in regard to its role in the regulation of human embryonic stem cells (hESCs). However, the results are controversial and the mechanism by which β-catenin regulates the hESC fate… read more here.
Keywords: hesc differentiation; catenin; tcf1; gata6 ... See more keywords
Label-free Quantitative Proteomics for Investigation of Signaling Pathways of GATA6 Regulating Trastuzumab Resistance in Gastric Cancer Cells
Sign Up to like & getrecommendations! Published in 2020 at "Chinese Journal of Analytical Chemistry"
DOI: 10.1016/s1872-2040(19)61215-6
Abstract: Abstract Trastuzumab resistance is one of the principal causes of failure in tumor chemotherapy. Previous studies showed that the DNA-binding activity of GATA6, a transcription factor, had a remarkable enhancement in trastuzumab resistant gastric cancer… read more here.
Keywords: trastuzumab resistance; gastric cancer; trastuzumab; gata6 ... See more keywords
Multiple roles and regulatory mechanisms of the transcription factor GATA6 in human cancers
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Genetics"
DOI: 10.1111/cge.13630
Abstract: Cancer is a common type of non‐communicable disease, and its morbidity and mortality are rapidly increasing. It is expected to become the largest obstacle to the promotion of global human health in the future. Some… read more here.
Keywords: gata6; transcription factor; factor gata6; multiple roles ... See more keywords
GATA6 Regulates Aortic Valve Remodeling, and Its Haploinsufficiency Leads to Right-Left Type Bicuspid Aortic Valve
Sign Up to like & getrecommendations! Published in 2018 at "Circulation"
DOI: 10.1161/circulationaha.117.029506
Abstract: Background: Bicuspid aortic valve (BAV), the most common congenital heart defect affecting 1% to 2% of the population, is a major risk factor for premature aortic valve disease and accounts for the majority of valve… read more here.
Keywords: aortic valve; gata6; bicuspid aortic; right left ... See more keywords
LncRNA GATA6-AS inhibits cancer cell proliferation and promotes cancer cell apoptosis in cervical cancer by down-regulating miR-205
Sign Up to like & getrecommendations! Published in 2020 at "BMC Women's Health"
DOI: 10.1186/s12905-020-01082-7
Abstract: Background Dysregulated endothelial cell growth is involved in many types of human cancer, including cervical cancer. LncRNA GATA6-AS was reported to regulate endothelial cell growth, suggesting it might involve in cervical cancer. Our study was… read more here.
Keywords: mir 205; gata6; expression; cancer ... See more keywords
GATA6 Controls Insulin Biosynthesis and Secretion in Adult β-Cells
Sign Up to like & getrecommendations! Published in 2017 at "Diabetes"
DOI: 10.2337/db17-0364
Abstract: GATA4 and GATA6 play essential, but redundant, roles in pancreas formation in mice, and GATA6 mutations cause pancreatic agenesis in humans. GATA6 mutations have also recently been linked to adult-onset diabetes, with subclinical or no… read more here.
Keywords: secretion; adult; adult cells; role gata6 ... See more keywords
Duplication in ECR near HMX1 and a SNP in GATA6 Genes Regulate Microtia in Awassi Sheep
Sign Up to like & getrecommendations! Published in 2020 at "Genes"
DOI: 10.3390/genes11060597
Abstract: Microtia and anotia are hereditary traits characterized by an underdevelopment or complete absence of the outer ear. These congenital malformations observed in many species can exist as part of various syndromes or as an isolated… read more here.
Keywords: microtia; gata6; near hmx1; ecr near ... See more keywords
Roles of GATA6 during Gonadal Development in Japanese Flounder: Gonadogenesis, Regulation of Gender-Related Genes, Estrogen Formation and Gonadal Function Maintenance
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms18010160
Abstract: GATA-binding protein 6 (GATA6), a highly-conserved transcription factor of the GATA family plays an important role in gonadal cell proliferation, differentiation and endoderm development. In this study, the full-length cDNA of GATA6 of Paralichthys olivaceus… read more here.
Keywords: olivaceus gata6; japanese flounder; gonadal development; gata6 ... See more keywords
A tissue-specific, Gata6-driven transcriptional program instructs remodeling of the mature arterial tree
Sign Up to like & getrecommendations! Published in 2017 at "eLife"
DOI: 10.7554/elife.31362
Abstract: Connection of the heart to the systemic circulation is a critical developmental event that requires selective preservation of embryonic vessels (aortic arches). However, why some aortic arches regress while others are incorporated into the mature… read more here.
Keywords: tissue specific; tree; gata6; gata6 driven ... See more keywords