Structure Optimization of Gatastatin for the Development of γ-Tubulin-Specific Inhibitor.
Sign Up to like & getrecommendations! Published in 2020 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.9b00526
Abstract: Gatastatin (O 7-benzyl glaziovianin A) is a γ-tubulin-specific inhibitor that is used to investigate γ-tubulin function in cells. We have previously reported that the unsubstituted phenyl ring of the O 7-benzyl group in gatastatin is… read more here.
Keywords: tubulin specific; structure optimization; gatastatin; specific inhibitor ... See more keywords
Computational Analysis and Experimental Testing of the Molecular Mode of Action of Gatastatin and Its Derivatives
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DOI: 10.3390/cancers15061714
Abstract: Simple Summary The glaziovianin A derivative gatastatin, presented as a γ-tubulin-specific inhibitor, could represent a viable chemotherapeutic strategy to solve the specificity issues associated with targeting α and β tubulin. Since gatastatin’s specificity for γ… read more here.
Keywords: gatastatin derivatives; analysis; specificity; tubulin ... See more keywords