The voltage‐gated calcium channel CaV1.2 promotes adult oligodendrocyte progenitor cell survival in the mouse corpus callosum but not motor cortex
Sign Up to like & getrecommendations! Published in 2019 at "Glia"
DOI: 10.1002/glia.23723
Abstract: Throughout life, oligodendrocyte progenitor cells (OPCs) proliferate and differentiate into myelinating oligodendrocytes. OPCs express cell surface receptors and channels that allow them to detect and respond to neuronal activity, including voltage‐gated calcium channel (VGCC)s. The… read more here.
Keywords: channel; gated calcium; cav1; cell ... See more keywords
Trimethyltin Increases Intracellular Ca2+ Via L-Type Voltage-Gated Calcium Channels and Promotes Inflammatory Phenotype in Rat Astrocytes In Vitro
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Neurobiology"
DOI: 10.1007/s12035-020-02273-x
Abstract: Astrocytes are the first responders to noxious stimuli by undergoing cellular and functional transition referred as reactive gliosis. Every acute or chronic disorder is accompanied by reactive gliosis, which could be categorized as detrimental (A1)… read more here.
Keywords: tmt induced; type voltage; calcium channels; gated calcium ... See more keywords
All Talk, No Assembly: Voltage-Gated Calcium Channels Do Not Mediate Active Zone Formation
Sign Up to like & getrecommendations! Published in 2020 at "Neuron"
DOI: 10.1016/j.neuron.2020.07.028
Abstract: How synapses assemble remains unknown. In this issue of Neuron, Held et al. (2020) demonstrate that Cav2-type voltage-gated calcium channels do not mediate presynaptic assembly. Moreover, the channel-associated protein α2δ localizes independently, suggesting additional functions for… read more here.
Keywords: calcium channels; gated calcium; channels mediate; voltage gated ... See more keywords
Pre‐clinical evaluation of voltage‐gated calcium channel blockers derived from the spider P. nigriventer in glioma progression
Sign Up to like & getrecommendations! Published in 2017 at "Toxicon"
DOI: 10.1016/j.toxicon.2017.02.001
Abstract: Abstract This study investigated the effects of P/Q‐ and N‐type voltage‐gated calcium channel (VGCC) blockers derived from P. nigriventer in glioma progression, by means of in vitro and in vivo experiments. Glioma cells M059J, U‐138MG… read more here.
Keywords: agr bgr; glioma; type vgcc; gated calcium ... See more keywords
Identification of ultra-rare disruptive variants in voltage-gated calcium channel-encoding genes in Japanese samples of schizophrenia and autism spectrum disorder
Sign Up to like & getrecommendations! Published in 2022 at "Translational Psychiatry"
DOI: 10.1038/s41398-022-01851-y
Abstract: Several large-scale whole-exome sequencing studies in patients with schizophrenia (SCZ) and autism spectrum disorder (ASD) have identified rare variants with modest or strong effect size as genetic risk factors. Dysregulation of cellular calcium homeostasis might… read more here.
Keywords: ultra rare; channel; gated calcium; autism spectrum ... See more keywords
Structure of the hyperosmolality-gated calcium-permeable channel OSCA1.2
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-07564-5
Abstract: In plants, hyperosmolality stimuli triggers opening of the osmosensitive channels, leading to a rapid downstream signaling cascade initiated by cytosolic calcium concentration elevation. Members of the OSCA family in Arabidopsis thaliana, identified as the hyperosmolality-gated… read more here.
Keywords: gated calcium; hyperosmolality gated; structure; hyperosmolality ... See more keywords
CACHD1: A new activity-modifying protein for voltage-gated calcium channels
Sign Up to like & getrecommendations! Published in 2019 at "Channels"
DOI: 10.1080/19336950.2019.1600968
Abstract: Autocommentary to: Cottrell GS, Soubrane CH, Hounshell JA, Lin H, Owenson V, Rigby M, Cox PJ, Barker BS, Ottolini M, Ince S, Bauer, CC, Perez-Reyes E, Patel MK, Stevens EB, Stephens GJ (2018) CACHD1 is… read more here.
Keywords: cachd1 new; channels cachd1; gated calcium; activity ... See more keywords
The role of voltage-gated calcium channels in the mechanisms of anesthesia and perioperative analgesia
Sign Up to like & getrecommendations! Published in 2022 at "Current Opinion in Anaesthesiology"
DOI: 10.1097/aco.0000000000001159
Abstract: Purpose of review A family of neuronal voltage-gated calcium channels (VGCCs) have received only recently a significant consideration regarding the mechanisms of anesthesia because VGCC inhibition may be important in anesthetic action by decreasing neuronal… read more here.
Keywords: mechanisms anesthesia; voltage gated; role; perioperative analgesia ... See more keywords
Voltage-gated calcium channel α 2δ subunits: an assessment of proposed novel roles
Sign Up to like & getrecommendations! Published in 2018 at "F1000Research"
DOI: 10.12688/f1000research.16104.1
Abstract: Voltage-gated calcium (CaV) channels are associated with β and α2δ auxiliary subunits. This review will concentrate on the function of the α2δ protein family, which has four members. The canonical role for α2δ subunits is… read more here.
Keywords: calcium channel; gated calcium; novel roles; voltage gated ... See more keywords
Protective effects of voltage-gated calcium channel antagonists against zinc toxicity in SN56 neuroblastoma cholinergic cells
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0209363
Abstract: One of the pathological site effects in excitotoxic activation is Zn2+ overload to postsynaptic neurons. Such an effect is considered to be equivalent to the glutamate component of excitotoxicity. Excessive uptake of Zn2+ by active… read more here.
Keywords: voltage gated; acetyl coa; gated calcium; zn2 ... See more keywords
Systematic Review of Voltage-Gated Calcium Channel α2δ Subunit Ligands for the Treatment of Chronic Neuropathic Pain and Insight into Structure-Activity Relationship (SAR) by Pharmacophore Modeling.
Sign Up to like & getrecommendations! Published in 2022 at "Current medicinal chemistry"
DOI: 10.2174/0929867329666220407093727
Abstract: BACKGROUND Neuropathic pain (NP) is a complex symptom related to the nerve damage. The discovery of new drugs for treating chronic NP has been continuing for several decades, while more progress is still needed to… read more here.
Keywords: voltage gated; treatment chronic; neuropathic pain; treatment ... See more keywords